Search Results - "Lourenzoni, Marcos Roberto"

In silico and in vivo analysis reveal impact of c-Myc tag in FMC63 scFv-CD19 protein interface and CAR-T cell efficacy by Lima, Ana Julia Ferreira, Hajdu, Karina Lobo, Abdo, Luiza, Batista-Silva, Leonardo Ribeiro, de Oliveira Andrade, Clara, Correia, Eduardo Mannarino, Aragão, Emmanuel Arthur Albuquerque, Bonamino, Martín Hernán, Lourenzoni, Marcos Roberto

“…Anti-CD19 CAR-T cell therapy represents a breakthrough in the treatment of B-cell malignancies, and it is expected that this therapy modality will soon cover a…”
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Frutapin, a lectin from Artocarpus incisa (breadfruit): cloning, expression and molecular insights by de Sousa, Felipe Domingos, da Silva, Bruno Bezerra, Furtado, Gilvan Pessoa, Carneiro, Igor de Sa, Lobo, Marina Duarte Pinto, Guan, Yiwei, Guo, Jingxu, Coker, Alun R, Lourenzoni, Marcos Roberto, Guedes, Maria Izabel Florindo, Owen, James S, Abraham, David J, Monteiro-Moreira, Ana Cristina de Oliveira, Moreira, Renato de Azevedo

“…(breadfruit) seeds contain three different lectins (Frutalin, Frutapin (FTP) and Frutackin) with distinct carbohydrate specificities. The most abundant lectin…”
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Structural evolution of an amphibian-specific globin: A computational evolutionary biochemistry approach by Queiroz, João Pedro Fernandes, Lourenzoni, Marcos Roberto, Rocha, Bruno Anderson Matias

“…Studies on the globin family are continuously revealing insights into the mechanisms of gene and protein evolution. The rise of a new globin gene type in…”
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Alemtuzumab scFv fragments and CD52 interaction study through molecular dynamics simulation and binding free energy by Frota, Natália Fernandes, Rebouças, Alison de Sousa, Fuzo, Carlos Alessandro, Lourenzoni, Marcos Roberto

“…Specific antibody-antigen recognition is crucial for the immune response. Knowledge of molecular interaction details in the recognition process is fundamental…”
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Molecular dynamics simulations of human L-asparaginase1: Insights into structural determinants of enzymatic activity by Guimarães, Ana Virginia Frota, Frota, Natália Fernandes, Lourenzoni, Marcos Roberto

“…The l-asparaginase enzyme is used in cancer therapy, mainly acute lymphoid leukemia (ALL). Commercial enzymes (EcASNase2) cause adverse reactions during…”
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Selective xyloglucan oligosaccharide hydrolysis by a GH31 α-xylosidase from Escherichia coli by Carneiro, Lara Aparecida Buffoni de Campos, Fuzo, Carlos Alessandro, Meleiro, Luana Parras, Carli, Sibeli, Barreto, Matheus Quintana, Lourenzoni, Marcos Roberto, Buckeridge, Marcos Silveira, Ward, Richard John

“…Xyloglucan is ubiquitous in the cell walls of land plants and is also an essential storage polymer in seeds of many species. We studied the hydrolysis of the…”
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Engineering the affinity of a family 11 carbohydrate binding module to improve binding of branched over unbranched polysaccharides by Furtado, Gilvan Pessoa, Lourenzoni, Marcos Roberto, Fuzo, Carlos Alessandro, Fonseca-Maldonado, Raquel, Guazzaroni, María-Eugenia, Ribeiro, Lucas Ferreira, Ward, Richard J.

“…Carbohydrate binding modules (CBMs) are non-catalytic domains within larger multidomain polypeptides. The CelH from Ruminoclostridium (Clostridium)…”
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A natural cell-penetrating nanopeptide combined with pentavalent antimonial as experimental therapy against cutaneous leishmaniasis by Valentim Silva, João Rafael, de Barros, Neuza Biguinati, Aragão Macedo, Sharon Rose, Ferreira, Amália dos Santos, Moreira Dill, Leandro Soares, Zanchi, Fernando Berton, do Nascimento, Johnny Ramos, Fernandes do Nascimento, Flávia Raquel, Lourenzoni, Marcos Roberto, de Azevedo Calderon, Leonardo, Soares, Andreimar Martins, Nicolete, Roberto

“…The inadequacy of available treatments for leishmaniasis has presented up to 40% therapeutic failure. This fact suggests an urgency in the discovery of new…”
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Hydrogel and membrane scaffold formulations of Frutalin (breadfruit lectin) within a polysaccharide galactomannan matrix have potential for wound healing by de Sousa, Felipe Domingos, Vasconselos, Pedrinha Diógenes, da Silva, Ayrles Fernanda Brandão, Mota, Erika Freitas, da Rocha Tomé, Adriana, Mendes, Francisco Rogênio da Silva, Gomes, Anida Maria Moraes, Abraham, David J, Shiwen, Xu, Owen, James S, Lourenzoni, Marcos Roberto, Campos, Adriana Rolim, Moreira, Renato de Azevedo, Monteiro-Moreira, Ana Cristina de Oliveira

“…Plant lectins are carbohydrate-binding proteins, which can interact with cell surfaces to initiate anti-inflammatory pathways, as well as immunomodulatory…”
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GXMR-CAR containing distinct GXM-specific single-chain variable fragment (scFv) mediated the cell activation against Cryptococcus spp. And had difference in the strength of tonic signaling by Machado, Michele Procópio, Dos Santos, Matheus Henrique, Guimarães, Júlia Garcia, de Campos, Gabriela Yamazaki, Oliveira Brito, Patrícia Kellen Martins, Ferreira, Camilly Melo Garcia, Rezende, Caroline Patini, Frota, Natália Fernandes, Soares, Sandro Gomes, Kumaresan, Pappanaicken R, Lourenzoni, Marcos Roberto, da Silva, Thiago Aparecido

“…Cryptococcus spp. has a polysaccharide capsule composed of glucuronoxylomannan-GXM, a major virulence factor that can prevent the recognition of fungi by…”
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The role of local residue environmental changes in thermostable mutants of the GH11 xylanase from Bacillus subtilis by Silva, Sérgio Bergamachi, Pinheiro, Matheus Pinto, Fuzo, Carlos Alessandro, Silva, Samuel Reghim, Ferreira, Tatiane Lopes, Lourenzoni, Marcos Roberto, Nonato, M. Cristina, Vieira, Davi Serradella, Ward, Richard John

“…[Display omitted] •The crystal structure of a thermostable quadruple GH11 xylanase mutant was determined.•Molecular dynamics simulations were performed for the…”
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RETRACTED: Hydrogel and membrane scaffold formulations of Frutalin (breadfruit lectin) within a polysaccharide galactomannan matrix have potential for wound healing by de Sousa, Felipe Domingos, Vasconselos, Pedrinha Diógenes, da Silva, Ayrles Fernanda Brandão, Mota, Erika Freitas, da Rocha Tomé, Adriana, Mendes, Francisco Rogênio da Silva, Gomes, Anida Maria Moraes, Abraham, David J., Shiwen, Xu, Owen, James S., Lourenzoni, Marcos Roberto, Campos, Adriana Rolim, Moreira, Renato de Azevedo, Monteiro-Moreira, Ana Cristina de Oliveira

“…This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/locate/withdrawalpolicy). This article has been…”
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Characterization of suramin binding sites on the human group IIA secreted phospholipase A2 by site-directed mutagenesis and molecular dynamics simulation by Aragão, Elisângela Aparecida, Vieira, Davi Serradella, Chioato, Lucimara, Ferreira, Tatiana Lopes, Lourenzoni, Marcos Roberto, Silva, Samuel Reghim, Ward, Richard John

“…[Display omitted] ► The polyanion suramin is a human GIIA phospholipase A2 (hsPLA2GIIA) inhibitor. ► Single cationic residue mutants show increased or…”
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Mapping of suramin binding sites on the group IIA human secreted phospholipase A2 by Vieira, Davi Serradella, Aragão, Elisangela Aparecida, Lourenzoni, Marcos Roberto, Ward, Richard J

“…Suramin is a polysulphonated napthylurea used as an antiprotozoal/anthelminitic drug, which also inhibits a broad range of enzymes. Suramin binding to…”
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Mapping of suramin binding sites on the group IIA human secreted phospholipase A 2 by Vieira, Davi Serradella, Aragão, Elisangela Aparecida, Lourenzoni, Marcos Roberto, Ward, Richard J.

“…Suramin is a polysulphonated napthylurea used as an antiprotozoal/anthelminitic drug, which also inhibits a broad range of enzymes. Suramin binding to…”
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