Search Results - "Lourenco, Mychael V"

Protective actions of exercise‐related FNDC5/Irisin in memory and Alzheimer’s disease by Freitas, Guilherme B., Lourenco, Mychael V., De Felice, Fernanda G.

“…The proportion of elderly populations is rapidly booming, and human lifespan has considerably increased in the past century because of scientific and medical…”
Get full text

How does brain insulin resistance develop in Alzheimer's disease? by De Felice, Fernanda G, Lourenco, Mychael V, Ferreira, Sergio T

“…Abstract Compelling preclinical and clinical evidence supports a pathophysiological connection between Alzheimer's disease (AD) and diabetes. Altered…”
Get full text

Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects by Frozza, Rudimar L, Lourenco, Mychael V, De Felice, Fernanda G

“…Alzheimer's disease (AD), the most common form of dementia in late life, will become even more prevalent by midcentury, constituting a major global health…”
Get full text

How does the skeletal muscle communicate with the brain in health and disease? by Isaac, Alinny R., Lima-Filho, Ricardo A.S., Lourenco, Mychael V.

“…Endocrine mechanisms have been largely associated with metabolic control and tissue cross talk in mammals. Classically, myokines comprise a class of signaling…”
Get full text

Synaptopathies: synaptic dysfunction in neurological disorders – A review from students to students by Lepeta, Katarzyna, Lourenco, Mychael V., Schweitzer, Barbara C., Martino Adami, Pamela V., Banerjee, Priyanjalee, Catuara‐Solarz, Silvina, La Fuente Revenga, Mario, Guillem, Alain Marc, Haidar, Mouna, Ijomone, Omamuyovwi M., Nadorp, Bettina, Qi, Lin, Perera, Nirma D., Refsgaard, Louise K., Reid, Kimberley M., Sabbar, Mariam, Sahoo, Arghyadip, Schaefer, Natascha, Sheean, Rebecca K., Suska, Anna, Verma, Rajkumar, Vicidomini, Cinzia, Wright, Dean, Zhang, Xing‐Ding, Seidenbecher, Constanze

“…Synapses are essential components of neurons and allow information to travel coordinately throughout the nervous system to adjust behavior to environmental…”
Get full text

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys by Lourenco, Mychael V., Clarke, Julia R., Frozza, Rudimar L., Bomfim, Theresa R., Forny-Germano, Letícia, Batista, André F., Sathler, Luciana B., Brito-Moreira, Jordano, Amaral, Olavo B., Silva, Cesar A., Freitas-Correa, Léo, Espírito-Santo, Sheila, Campello-Costa, Paula, Houzel, Jean-Christophe, Klein, William L., Holscher, Christian, Carvalheira, José B., Silva, Aristobolo M., Velloso, Lício A., Munoz, Douglas P., Ferreira, Sergio T., De Felice, Fernanda G.

“…Alzheimer’s disease (AD) and type 2 diabetes appear to share similar pathogenic mechanisms. dsRNA-dependent protein kinase (PKR) underlies peripheral insulin…”
Get full text

Effects of Gestational Exercise on Nociception, BDNF, and Irisin Levels in an Animal Model of ADHD by Tosta, Andréa, Fonseca, Ariene S., Messeder, Débora, Ferreira, Sérgio T., Lourenco, Mychael V., Pandolfo, Pablo

“…[Display omitted] •The SHR rat strain is considered a suitable ADHD animal model.•SHR present memory deficit, delayed nociception, and low D2R and BDNF brain…”
Get full text

Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer's disease by De Felice, Fernanda G, Lourenco, Mychael V

“…Brain metabolic dysfunction is known to influence brain activity in several neurological disorders, including Alzheimer's disease (AD). In fact, deregulation…”
Get full text

Metabolic Dysfunction in Alzheimer's Disease: From Basic Neurobiology to Clinical Approaches by Clarke, Julia R, Ribeiro, Felipe C, Frozza, Rudimar L, De Felice, Fernanda G, Lourenco, Mychael V

“…Clinical trials have extensively failed to find effective treatments for Alzheimer's disease (AD) so far. Even after decades of AD research, there are still…”
Get more information

The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasis by Duran-Aniotz, Claudia, Poblete, Natalia, Rivera-Krstulovic, Catalina, Ardiles, Álvaro O., Díaz-Hung, Mei Li, Tamburini, Giovanni, Sabusap, Carleen Mae P., Gerakis, Yannis, Cabral-Miranda, Felipe, Diaz, Javier, Fuentealba, Matias, Arriagada, Diego, Muñoz, Ernesto, Espinoza, Sandra, Martinez, Gabriela, Quiroz, Gabriel, Sardi, Pablo, Medinas, Danilo B., Contreras, Darwin, Piña, Ricardo, Lourenco, Mychael V., Ribeiro, Felipe C., Ferreira, Sergio T., Rozas, Carlos, Morales, Bernardo, Plate, Lars, Gonzalez-Billault, Christian, Palacios, Adrian G., Hetz, Claudio

“…Alteration in the buffering capacity of the proteostasis network is an emerging feature of Alzheimer’s disease (AD), highlighting the occurrence of endoplasmic…”
Get full text

Integrated Stress Response: Connecting ApoE4 to Memory Impairment in Alzheimer's Disease by Oliveira, Mauricio M, Lourenco, Mychael V

Get full text

Irisin stimulates protective signaling pathways in rat hippocampal neurons by Lourenco, Mychael V., de Freitas, Guilherme B., Raony, Ícaro, Ferreira, Sergio T., De Felice, Fernanda G.

“…Physical exercise stimulates neuroprotective pathways, has pro-cognitive actions, and alleviates memory impairment in Alzheimer’s disease (AD). Irisin is an…”
Get full text

Cerebrospinal fluid irisin correlates with amyloid‐β, BDNF, and cognition in Alzheimer's disease by Lourenco, Mychael V., Ribeiro, Felipe C., Sudo, Felipe K., Drummond, Cláudia, Assunção, Naima, Vanderborght, Bart, Tovar‐Moll, Fernanda, Mattos, Paulo, De Felice, Fernanda G., Ferreira, Sergio T.

“…Introduction: Irisin is a novel hormone originally identified for its role as a regulator of peripheral metabolism and recently found to protect synapses and…”
Get full text

Defective regulation of the eIF2-eIF2B translational axis underlies depressive-like behavior in mice and correlates with major depressive disorder in humans by Isaac, Alinny R., Chauvet, Mariana G., Lima-Filho, Ricardo, Wagner, Beatriz de A., Caroli, Bruno G., Leite, Renata E. P., Suemoto, Claudia K., Nunes, Paula Villela, De Felice, Fernanda G., Ferreira, Sergio T., Lourenco, Mychael V.

“…Major depressive disorder (MDD) is a significant cause of disability in adults worldwide. However, the underlying causes and mechanisms of MDD are not fully…”
Get full text

Preface: Special issue “Brain Proteostasis in Health and Disease” by Lourenco, Mychael V.

“…This preface introduces the Journal of Neurochemistry Special Issue on Brain Proteostasis. Adequate control of protein homeostasis, or proteostasis, has been…”
Get full text

Age-linked suppression of lipoxin A4 associates with cognitive deficits in mice and humans by Pamplona, Fabricio A., Vitória, Gabriela, Sudo, Felipe K., Ribeiro, Felipe C., Isaac, Alinny R., Moraes, Carolina A., Chauvet, Mariana G., Ledur, Pitia Flores, Karmirian, Karina, Ornelas, Isis M., Leo, Luciana M., Paulsen, Bruna, Coutinho, Gabriel, Drummond, Claudia, Assunção, Naima, Vanderborght, Bart, Canetti, Claudio A., Castro-Faria-Neto, Hugo C., Mattos, Paulo, Ferreira, Sergio T., Rehen, Stevens K., Bozza, Fernando A., Lourenco, Mychael V., Tovar-Moll, Fernanda

“…Age increases the risk for cognitive impairment and is the single major risk factor for Alzheimer’s disease (AD), the most prevalent form of dementia in the…”
Get full text

Promoting diversity and overcoming publication barriers in Latin American neuroscience and Alzheimer's disease research: A call to action by Lourenco, Mychael V., Borelli, Wyllians Vendramini, Duran‐Aniotz, Claudia, Zimmer, Eduardo R., Castro, Shamyr Sulyvan

“…Alzheimer's disease (AD) is a global health issue. Because AD is a condition demanding effective management, its socioeconomic burden is immense and threatens…”
Get full text

Cross-species comparative hippocampal transcriptomics in Alzheimer’s disease by De Bastiani, Marco Antônio, Bellaver, Bruna, Carello-Collar, Giovanna, Zimmermann, Maria, Kunach, Peter, Lima-Filho, Ricardo A.S., Forner, Stefania, Martini, Alessandra Cadete, Pascoal, Tharick A., Lourenco, Mychael V., Rosa-Neto, Pedro, Zimmer, Eduardo R.

“…Alzheimer’s disease (AD) is a multifactorial pathology, with most cases having a sporadic origin. Recently, knock-in (KI) mouse models, such as the novel…”
Get full text

Irisin limits amyloid-β buildup in Alzheimer’s disease by Lourenco, Mychael V.

“…Mounting evidence suggests that physical exercise protects the brain against neurodegenerative disease. In a recent paper in Neuron, Kim et al. reported that…”
Get full text

Synaptic proteasome is inhibited in Alzheimer’s disease models and associates with memory impairment in mice by Ribeiro, Felipe C., Cozachenco, Danielle, Heimfarth, Luana, Fortuna, Juliana T. S., de Freitas, Guilherme B., de Sousa, Jorge M., Alves-Leon, Soniza V., Leite, Renata E. P., Suemoto, Claudia K., Grinberg, Lea T., De Felice, Fernanda G., Lourenco, Mychael V., Ferreira, Sergio T.

“…The proteasome plays key roles in synaptic plasticity and memory by regulating protein turnover, quality control, and elimination of oxidized/misfolded…”
Get full text