Search Results - "Lourenço, André"

Randomized controlled trial of remote ischaemic conditioning in ST-elevation myocardial infarction as adjuvant to primary angioplasty (RIC-STEMI) by Gaspar, António, Lourenço, André P., Pereira, Miguel Álvares, Azevedo, Pedro, Roncon-Albuquerque, Roberto, Marques, Jorge, Leite-Moreira, Adelino F.

“…To test whether remote ischaemic conditioning (RIC) as adjuvant to standard of care (SOC) would prevent progression towards heart failure (HF) after…”
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Physiological, pathological and potential therapeutic roles of adipokines by FAKAO-PIRES, Inês, CASTRO-CHAVES, Paulo, MIRANDA-SILVA, Daniela, LOURENCO, André P, LEITE-MOREIRA, Adelino F

“…Formerly regarded purely as passive energy storage, adipose tissue is now recognized as a vital endocrine organ. Adipocytes secrete diverse peptide hormones…”
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Structure-Based Identification of Naphthoquinones and Derivatives as Novel Inhibitors of Main Protease Mpro and Papain-like Protease PLpro of SARS-CoV‑2 by Santos, Lucianna H., Kronenberger, Thales, Almeida, Renata G., Silva, Elany B., Rocha, Rafael E. O., Oliveira, Joyce C., Barreto, Luiza V., Skinner, Danielle, Fajtová, Pavla, Giardini, Miriam A., Woodworth, Brendon, Bardine, Conner, Lourenço, André L., Craik, Charles S., Poso, Antti, Podust, Larissa M., McKerrow, James H., Siqueira-Neto, Jair L., O’Donoghue, Anthony J., da Silva Júnior, Eufrânio N., Ferreira, Rafaela S.

“…The worldwide COVID-19 pandemic caused by the coronavirus SARS-CoV-2 urgently demands novel direct antiviral treatments. The main protease (Mpro) and…”
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Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function by Zacchigna, Serena, Paldino, Alessia, Falcão-Pires, Inês, Daskalopoulos, Evangelos P, Dal Ferro, Matteo, Vodret, Simone, Lesizza, Pierluigi, Cannatà, Antonio, Miranda-Silva, Daniela, Lourenço, André P, Pinamonti, Bruno, Sinagra, Gianfranco, Weinberger, Florian, Eschenhagen, Thomas, Carrier, Lucie, Kehat, Izhak, Tocchetti, Carlo G, Russo, Michele, Ghigo, Alessandra, Cimino, James, Hirsch, Emilio, Dawson, Dana, Ciccarelli, Michele, Oliveti, Marco, Linke, Wolfgang A, Cuijpers, Ilona, Heymans, Stephane, Hamdani, Nazha, de Boer, Martine, Duncker, Dirk J, Kuster, Diederik, van der Velden, Jolanda, Beauloye, Christophe, Bertrand, Luc, Mayr, Manuel, Giacca, Mauro, Leuschner, Florian, Backs, Johannes, Thum, Thomas

“…Abstract Echocardiography is a reliable and reproducible method to assess non-invasively cardiac function in clinical and experimental research. Significant…”
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Human umbilical cord tissue-derived mesenchymal stromal cells as adjuvant therapy for myocardial infarction: a review of current evidence focusing on pre-clinical large animal models and early human trials by Raposo, Luís, Lourenço, André P., Nascimento, Diana S., Cerqueira, Rui, Cardim, Nuno, Leite-Moreira, Adelino

“…Although biologically appealing, the concept of tissue regeneration underlying first- and second-generation cell therapies has failed to translate into…”
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A directed network analysis of the cardiome identifies molecular pathways contributing to the development of HFpEF by Summer, Georg, Kuhn, Annika R., Munts, Chantal, Miranda-Silva, Daniela, Leite-Moreira, Adelino F., Lourenço, André P., Heymans, Stephane, Falcão-Pires, Inês, van Bilsen, Marc

“…The metabolic syndrome and associated comorbidities, like diabetes, hypertension and obesity, have been implicated in the development of heart failure with…”
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Acute and chronic effects of levosimendan in the ZSF1 obese rat model of heart failure with preserved ejection fraction by Moreira-Costa, Liliana, Tavares-Silva, Marta, Almeida-Coelho, João, Gonçalves, Alexandre, Trindade, Fábio, Vasques-Nóvoa, Francisco, Sousa-Mendes, Cláudia, Leite, Sara, Vitorino, Rui, Falcão-Pires, Inês, Leite-Moreira, Adelino F., Lourenço, André P.

“…Heart failure with preserved ejection fraction (HFpEF) is a syndrome characterized by impaired cardiovascular reserve in which therapeutic options are scarce…”
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Metformin hydrochloride sustained release biopolymeric system composed by PLLA‐CMC microparticles by Silva, Thiago Schroeder, Silva, Denise Abatti Kasper, Nogueira, André Lourenço

“…Metformin hydrochloride (MetHCl) is a drug extensively used to treat diabetes mellitus Type 2. However, its high hydrophilicity drastically reduces its…”
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Assessing Rodent Cardiac Function in vivo Using Hemodynamic Pressure-Volume Loops by Miranda-Silva, Daniela, Sequeira, Vasco, Lourenço, André P., Falcão-Pires, Inês

“…Heart failure (HF) triggered by cardiovascular and non-cardiovascular diseases is a leading cause of death worldwide and translational research is urgently…”
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Multiple versus single arterial grafting in coronary artery bypass grafting: A meta-analysis of randomized controlled trials and propensity score studies by Saraiva, Francisca A., Leite-Moreira, João P., Barros, António S., Lourenço, André P., Benedetto, Umberto, Leite-Moreira, Adelino F.

“…We conducted a meta-analysis of randomized controlled trials (RCTs) and propensity score (PS) studies comparing survival and major adverse cardiac and…”
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Right ventricular end-diastolic stiffness heralds right ventricular failure in monocrotaline-induced pulmonary hypertension by Alaa, Mohamed, Abdellatif, Mahmoud, Tavares-Silva, Marta, Oliveira-Pinto, José, Lopes, Lucas, Leite, Sara, Leite-Moreira, Adelino F, Lourenço, André P

“…Recent studies suggest right ventricular (RV) stiffness is important in pulmonary hypertension (PH) prognosis. Smaller stroke volume (SV) variation after a…”
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Exercise training impacts skeletal muscle remodelling induced by metabolic syndrome in ZSF1 rats through metabolism regulation by Nogueira-Ferreira, Rita, Santos, Inês, Ferreira, Rita, Fontoura, Dulce, Sousa-Mendes, Cláudia, Falcão-Pires, Inês, Lourenço, André P, Leite-Moreira, Adelino, Duarte, Iola F, Moreira-Gonçalves, Daniel

“…Metabolic syndrome (MetS), characterized by a set of conditions that include obesity, hypertension, and dyslipidemia, is associated with increased…”
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Arterial Remodeling and Dysfunction in the ZSF1 Rat Model of Heart Failure With Preserved Ejection Fraction by Leite, Sara, Cerqueira, Rui J, Ibarrola, Jaime, Fontoura, Dulce, Fernández-Celis, Amaya, Zannad, Faiez, Falcão-Pires, Inês, Paulus, Walter J, Leite-Moreira, Adelino F, Rossignol, Patrick, López-Andrés, Natalia, Lourenço, André P

“…The interplay between the stiffened heart and vessels has long been viewed as a core mechanism in heart failure with preserved ejection fraction, but the…”
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Afterload-induced diastolic dysfunction contributes to high filling pressures in experimental heart failure with preserved ejection fraction by Leite, Sara, Rodrigues, Sara, Tavares-Silva, Marta, Oliveira-Pinto, José, Alaa, Mohamed, Abdellatif, Mahmoud, Fontoura, Dulce, Falcão-Pires, Inês, Gillebert, Thierry C, Leite-Moreira, Adelino F, Lourenço, André P

“…Myocardial stiffness and upward-shifted end-diastolic pressure-volume (P-V) relationship (EDPVR) are the key to high filling pressures in heart failure with…”
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Stretch-induced compliance mechanism in pregnancy-induced cardiac hypertrophy and the impact of cardiovascular risk factors by Ferreira, Ana Filipa, Azevedo, Maria João, Morais, Juliana, Almeida-Coelho, João, Leite-Moreira, André M, Lourenço, André P, Saraiva, Francisca, Diaz, Sílvia O, Amador, Ana Filipa, Sousa, Carla, Machado, Ana Paula, Sampaio-Maia, Benedita, Ramalho, Carla, Leite-Moreira, Adelino, Barros, António S, Falcão-Pires, Inês

“…Pressure overload-induced hypertrophy compromises cardiac stretch-induced compliance (SIC) after acute volume overload (AVO). We hypothesized that SIC could be…”
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The impact of time-of-day reperfusion on remote ischemic conditioning in ST-elevation myocardial infarction: a RIC-STEMI substudy by Pires, Carla Marques, Lamas, Diana, Gaspar, António, Lourenço, André P., Antunes, Nuno, Marques, Jorge, Leite-Moreira, Adelino F.

“…Daytime variation affects the tolerance of cardiomyocytes to ischemia–reperfusion injury (IRI). This study aims to evaluate the impact of time-of-day…”
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Myosin-Inhibitor Mavacamten Acutely Enhances Cardiomyocyte Diastolic Compliance in Heart Failure With Preserved Ejection Fraction by Almeida-Coelho, João, Leite-Moreira, André M, Sequeira, Vasco, Hamdani, Nazha, Lourenço, André P, Falcão-Pires, Inês, Leite-Moreira, Adelino F

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Marine Diterpenes: Molecular Modeling of Thrombin Inhibitors with Potential Biotechnological Application as an Antithrombotic by Pereira, Rebeca Cristina Costa, Lourenço, André Luiz, Terra, Luciana, Abreu, Paula Alvarez, Laneuville Teixeira, Valéria, Castro, Helena Carla

“…Thrombosis related diseases are among the main causes of death and incapacity in the world. Despite the existence of antithrombotic agents available for…”
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Current pathophysiological concepts and management of pulmonary hypertension by Lourenço, André P, Fontoura, Dulce, Henriques-Coelho, Tiago, Leite-Moreira, Adelino F

“…Abstract Pulmonary hypertension (PH), increasingly recognized as a major health burden, remains underdiagnosed due mainly to the unspecific symptoms. Pulmonary…”
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Echocardiography and invasive hemodynamics during stress testing for diagnosis of heart failure with preserved ejection fraction: an experimental study by Leite, Sara, Oliveira-Pinto, José, Tavares-Silva, Marta, Abdellatif, Mahmoud, Fontoura, Dulce, Falcão-Pires, Inês, Leite-Moreira, Adelino F, Lourenço, André P

“…Inclusion of exercise testing in diagnostic guidelines for heart failure with preserved ejection fraction (HFpEF) has been advocated, but the target…”
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