Search Results - "Loureiro De Sousa, Paulo"
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Non-invasive assessment of skeletal muscle fibrosis in mice using nuclear magnetic resonance imaging and ultrasound shear wave elastography
Published in Scientific reports (11-01-2021)“…Fibrosis is a key pathological feature in muscle disorders, but its quantification mainly relies on histological and biochemical assays. Muscle fibrosis most…”
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2
The hippocampal region is necessary for text comprehension and memorization: a combined VBM/DTI study in neuropsychological patients
Published in Brain imaging and behavior (01-10-2021)“…According to the Construction-Integration model (Kintsch 1988 ; Kintsch 1998 ), two forms of representation are activated during the reading and the…”
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Insular atrophy at the prodromal stage of dementia with Lewy bodies: a VBM DARTEL study
Published in Scientific reports (25-08-2017)“…Diffuse atrophy including the insula was previously demonstrated in dementia with Lewy bodies (DLB) patients but little is known about the prodromal stage of…”
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Microstructural changes in prodromal dementia with Lewy bodies compared to normal ageing: Multiparametric quantitative MRI evidences
Published in The European journal of neuroscience (01-01-2022)“…Dementia with Lewy bodies (DLB) patients show few significant macroscopic structural changes, especially at the early stages of the disease, making…”
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Neural basis of writing in prodromal to mild dementia with lewy bodies
Published in International journal of geriatric psychiatry (01-01-2024)“…Objectives We have previously demonstrated difficulties in written production in dementia with Lewy bodies (DLB) patients. We now aim to determine the neural…”
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Correlations of quantitative MRI metrics with myelin basic protein (MBP) staining in a murine model of demyelination
Published in NMR in biomedicine (01-09-2019)“…Myelin imaging in the central nervous system is essential for monitoring pathologies involving white matter alterations. Various quantitative MRI protocols…”
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Association of cerebral microbleeds with cerebrospinal fluid Alzheimer‐biomarkers and clinical symptoms in early dementia with Lewy bodies
Published in International journal of geriatric psychiatry (01-06-2021)“…Objectives To determine the prevalence, localization and associations of cerebral microbleeds (CMB) in dementia with Lewy bodies (DLB) with its core clinical…”
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Pay attention to the basal ganglia: a volumetric study in early dementia with Lewy bodies
Published in Alzheimer's research & therapy (21-12-2019)“…Cortical and subcortical cognitive impairments are usually found in dementia with Lewy bodies (DLB). Roughly, they comprise visuo-constructive/executive…”
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Changes in gray matter volume and functional connectivity in dementia with Lewy bodies compared to Alzheimer's disease and normal aging: implications for fluctuations
Published in Alzheimer's research & therapy (06-01-2020)“…Fluctuations are one of the core clinical features characterizing dementia with Lewy bodies (DLB). They represent a determining factor for its diagnosis and…”
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Who am I with my Lewy bodies? The insula as a core region of the self-concept networks
Published in Alzheimer's research & therapy (19-04-2024)“…Dementia with Lewy bodies (DLB) is characterized by insular atrophy, which occurs at the early stage of the disease. Damage to the insula has been associated…”
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Prodromal characteristics of dementia with Lewy bodies: baseline results of the MEMENTO memory clinics nationwide cohort
Published in Alzheimer's research & therapy (19-07-2022)“…Abstract Background Isolated subjective cognitive impairment (SCI) and mild cognitive impairment (MCI) are the prodromal phases of dementia with Lewy bodies…”
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Fast Open-Source Toolkit for Water T2 Mapping in the Presence of Fat From Multi-Echo Spin-Echo Acquisitions for Muscle MRI
Published in Frontiers in neurology (26-02-2021)“…Imaging has become a valuable tool in the assessment of neuromuscular diseases, and, specifically, quantitative MR imaging provides robust biomarkers for the…”
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Brain dysmyelination and recovery assessment by noninvasive in vivo diffusion tensor magnetic resonance imaging
Published in Journal of neuroscience research (15-02-2006)“…Diffusion tensor magnetic resonance imaging (DT‐MRI) was applied for in vivo quantification of myelin loss and regeneration. A transgenic mouse line…”
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Differential diagnostic value of total alpha-synuclein assay in the cerebrospinal fluid between Alzheimer’s disease and dementia with Lewy bodies from the prodromal stage
Published in Alzheimer's research & therapy (29-09-2020)“…Abstract Background Several studies have investigated the value of alpha-synuclein assay in the cerebrospinal fluid (CSF) of Alzheimer’s disease (AD) and…”
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Neural basis of impaired narrative discourse comprehension in prodromal and mild dementia with lewy bodies
Published in Frontiers in aging neuroscience (15-09-2022)“…Narrative discourse (ND) comprehension is a complex task that implies not only linguistic abilities but also other cognitive abilities, including efficient…”
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A Brain Imaging-Based Diagnostic Biomarker for Periodic Catatonia: Preliminary Evidence Using a Bayesian Approach
Published in Neuropsychobiology (2020)“…Periodic catatonia (PC) is a psychomotor phenotype with a progressive-remitting course. While it can fit any disorder diagnosis of the schizoaffective…”
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BLOCH equations-based reconstruction of myocardium t1 maps from modified look-locker inversion recovery sequence
Published in PloS one (11-05-2015)“…Modified Look-Locker Inversion recovery (MOLLI) sequence is increasingly performed for myocardial T1 mapping but is known to underestimate T1 values. The aim…”
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The TOTEM RRMS (Testosterone Treatment on neuroprotection and Myelin Repair in Relapsing Remitting Multiple Sclerosis) trial: study protocol for a randomized, double-blind, placebo-controlled trial
Published in Current controlled trials in cardiovascular medicine (29-06-2020)“…Central nervous system damage in multiple sclerosis (MS) is responsible for serious deficiencies. Current therapies are focused on the treatment of…”
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MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies
Published in NPJ Parkinson's Disease (20-01-2023)“…Dementia with Lewy bodies (DLB) is a neurodegenerative disorder with a wide heterogeneity of symptoms, which suggests the existence of different subtypes. We…”
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Validation of a generic approach to muscle water T2 determination at 3T in fat-infiltrated skeletal muscle
Published in Journal of magnetic resonance imaging (01-03-2015)“…Purpose To introduce a novel method for skeletal muscle water T2 determination in fat‐infiltrated tissues, using a tri‐exponential fit of the global muscle…”
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