Search Results - "Loupe, P. S."

The effect of potent CYP2D6 inhibition on the pharmacokinetics and safety of deutetrabenazine in healthy volunteers by Schneider, F., Stamler, D., Bradbury, M. J., Loupe, P. S., Gordon, M. F., Rabinovich-Guilatt, L.

“…Purpose Deutetrabenazine is a deuterated form of tetrabenazine with a confirmed lower rate of CYP2D6 metabolism of the active metabolites, α- and β-HTBZ. In…”
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Cross-sensitization between footshock stress and apomorphine on self-injurious behavior and neostriatal catecholamines in a rat model of Lesch–Nyhan syndrome by Stodgell, Christopher J, Loupe, Pippa S, Schroeder, Stephen R, Tessel, Richard E

“…The effects of footshock sensitization (priming), apomorphine (APO) priming and their combination on behavior and neostriatal and cortical catecholamines were…”
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FR discrimination training effects in SHR and microencephalic rats by Loupe, Pippa S., Schroeder, Stephen R., Tessel, Richard E.

“…Fixed-ratio (FR) discrimination learning in adult male spontaneously hypertensive rats (SHR), methylazoxymethanol-induced microencephalic Sprague-Dawley (MAM),…”
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Reversal of 6HD-induced neonatal brain catecholamine depletion after operant training by Tessel, Richard E., Schroeder, Stephen R., Loupe, Pippa S., Stodgell, Christopher J.

“…Rats received either vehicle (controls) or 100 μg of 6-hydroxydopamine (6HD) base intracisternally on postnatal day 5. At 3 mo of age, striatal and cortical…”
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Using rule induction for prediction of self-injuring behavior in animal models of development disabilities by Loupe, P.S., Freeman, R.L., Grzymala-Busse, J.W., Schroeder, S.R.

“…The data mining system LERS (Learning from Examples using Rough Sets) was used to assess whether animal models of varying basal ganglia dopamine concentrations…”
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Fixed ratio discrimination training increases in vivo striatal dopamine in neonatal 6-OHDA-lesioned rats by Loupe, Pippa S, Zhou, Xiao, Davies, Malonne I, Schroeder, Stephen R, Tessel, Richard E, Lunte, Susan M

“…Massed training in the conditional discrimination task, the fixed ratio discrimination (FRD) task led to elevated extracellular dopamine (DA) concentrations in…”
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Dopamine re‐uptake inhibitor GBR‐12909 induction of aberrant behaviors in animal models of dopamine dysfunction by Loupe, Pippa S., Bredemeier, Jonna D., Schroeder, Stephen R., Tessel, Richard E.

“…Many individuals with mental retardation exhibit chronic aberrant behaviors (CABs) that includes hyperactive, stereotyped, aggressive, and self‐injurious…”
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Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of high-frequency episodic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study by Bigal, Marcelo E, Dr, Dodick, David W, MD, Rapoport, Alan M, MD, Silberstein, Stephen D, Prof, Ma, Yuju, MS, Yang, Ronghua, PhD, Loupe, Pippa S, PhD, Burstein, Rami, PhD, Newman, Lawrence C, MD, Lipton, Richard B, Prof

“…Summary Background Calcitonin gene-related peptide (CGRP) is a validated target for the treatment of episodic migraine. Here we assess the safety,…”
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Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of chronic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study by Bigal, Marcelo E, Dr, Edvinsson, Lars, Prof, Rapoport, Alan M, MD, Lipton, Richard B, Prof, Spierings, Egilius L H, MD, Diener, Hans-Christoph, Prof, Burstein, Rami, PhD, Loupe, Pippa S, PhD, Ma, Yuju, MS, Yang, Ronghua, PhD, Silberstein, Stephen D, Prof

“…Summary Background Benefits of calcitonin-gene related peptide (CGRP) inhibition have not been established in chronic migraine. Here we assess the safety,…”
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Effects of Neuroleptic and Anticonvulsant Drugs on Repeated Acquisition Learning in Microencephalic and Normal Rats by Loupe, Pippa S, Schroeder, Stephen R, Tessel, Richard E

“…Neuroleptic and anticonvulsant drugs are used to reduce the occurrence of aberrant behaviors, seizures, or both in individuals with mental retardation…”
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Pharmacokinetics, metabolism and safety of deuterated L‐DOPA (SD‐1077)/carbidopa compared to L‐DOPA/carbidopa following single oral dose administration in healthy subjects by Schneider, Frank, Erisson, Lavi, Beygi, Hooman, Bradbury, Margaret, Cohen‐Barak, Orit, Grachev, Igor D., Guzy, Serge, Loupe, Pippa S., Levi, Micha, McDonald, Mirna, Savola, Juha‐Matti, Papapetropoulos, Spyros, Tracewell, William G., Velinova, Maria, Spiegelstein, Ofer

“…Aims SD‐1077, a selectively deuterated precursor of dopamine (DA) structurally related to L‐3,4‐dihydroxyphenylalanine (L‐DOPA), is under development for…”
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