New-onset diabetes mellitus after heart transplantation in children - Incidence and risk factors

New-onset diabetes mellitus after heart transplantation in children - Incidence and risk factors

Diabetes mellitus is a recognized complication of SOT in adults and is associated with decreased graft and patient survival. Little is known about NOD in pediatric HT recipients. We aimed to characterize the incidence and describe risk factors for development of NOD after HT in children. Children wh...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric transplantation Vol. 20; no. 7; pp. 963 - 969
Main Authors: Sehgal, Swati, Bock, Matthew J., Louks Palac, Hannah, Brickman, Wendy J., Gossett, Jeffrey G., Marino, Bradley S., Backer, Carl L., Pahl, Elfriede
Format: Journal Article
Language:English
Published: Denmark Blackwell Publishing Ltd 01-11-2016
Subjects:
Adolescent
African Americans
Age Factors
Child
Child, Preschool
children
Databases, Factual
Diabetes Complications - diagnosis
diabetes mellitus
Diabetes Mellitus - diagnosis
Diabetes Mellitus - epidemiology
Diabetes Mellitus - ethnology
Diabetes Mellitus - etiology
Female
Graft Survival
Heart Failure - complications
Heart Failure - ethnology
Heart Failure - surgery
heart transplantation
Heart Transplantation - adverse effects
Humans
Incidence
Male
Obesity - complications
pediatric
Proportional Hazards Models
Risk Factors
Sex Factors
Time Factors
diabetes mellitus
children
heart transplantation
pediatric
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Diabetes mellitus is a recognized complication of SOT in adults and is associated with decreased graft and patient survival. Little is known about NOD in pediatric HT recipients. We aimed to characterize the incidence and describe risk factors for development of NOD after HT in children. Children who developed diabetes after HT were identified from the OPTN database. Demographic and clinical data before and after transplant were compared between patients with and without NOD. A total of 2056 children were included, 56% were male, 54% were Caucasian, and 62% had cardiomyopathy prior to HT. NOD developed in 219 children (11%) after HT. The incidence of NOD was 2.4, 9.0, and 10.4% at one, five, and 10 yr after HT, respectively. Obesity (HR: 4.32), dialysis prior to transplant (HR: 2.38), African American race (HR: 1.86), transplant before year 2000 (HR: 1.82), female gender (HR: 1.68), and older age at transplant (HR: 1.28) were independent predictors of NOD. The major modifiable risk factor for NOD is obesity, imparting the maximum hazard. Improved surveillance for diabetes in high‐risk patients and specific prevention and intervention strategies are imperative in this population.
Bibliography:ark:/67375/WNG-6362X9FS-Z
ArticleID:PETR12759
Figure S1 Survival curve for number at risk with each passing year.
istex:D617DC0C8626412E96BDD3BE8B9A2A9D4627DEC9
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1397-3142
1399-3046
DOI:10.1111/petr.12759