Search Results - "Loukola, Anu"

Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent by Buchwald, Jadwiga, Chenoweth, Meghan J., Palviainen, Teemu, Zhu, Gu, Benner, Christian, Gordon, Scott, Korhonen, Tellervo, Ripatti, Samuli, Madden, Pamela A. F., Lehtimäki, Terho, Raitakari, Olli T., Salomaa, Veikko, Rose, Richard J., George, Tony P., Lerman, Caryn, Pirinen, Matti, Martin, Nicholas G., Kaprio, Jaakko, Loukola, Anu, Tyndale, Rachel F.

“…Smoking behaviors, including amount smoked, smoking cessation, and tobacco-related diseases, are altered by the rate of nicotine clearance. Nicotine clearance…”
Get full text

A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism by Loukola, Anu, Buchwald, Jadwiga, Gupta, Richa, Palviainen, Teemu, Hällfors, Jenni, Tikkanen, Emmi, Korhonen, Tellervo, Ollikainen, Miina, Sarin, Antti-Pekka, Ripatti, Samuli, Lehtimäki, Terho, Raitakari, Olli, Salomaa, Veikko, Rose, Richard J, Tyndale, Rachel F, Kaprio, Jaakko

“…Individuals with fast nicotine metabolism typically smoke more and thus have a greater risk for smoking-induced diseases. Further, the efficacy of smoking…”
Get full text

Data-driven comorbidity analysis of 100 common disorders reveals patient subgroups with differing mortality risks and laboratory correlates by Koskinen, Miika, Salmi, Jani K., Loukola, Anu, Mäkelä, Mika J., Sinisalo, Juha, Carpén, Olli, Renkonen, Risto

“…The populational heterogeneity of a disease, in part due to comorbidity, poses several complexities. Individual comorbidity profiles, on the other hand,…”
Get full text

Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance by Utge, Siddheshwar J, Soronen, Pia, Loukola, Anu, Kronholm, Erkki, Ollila, Hanna M, Pirkola, Sami, Porkka-Heiskanen, Tarja, Partonen, Timo, Paunio, Tiina

“…Disturbances in the circadian pacemaker system are commonly found in individuals with depression and sleep-related problems. We hypothesized that some of the…”
Get full text

Association Between Genes of Disrupted in Schizophrenia 1 (DISC1) Interactors and Schizophrenia Supports the Role of the DISC1 Pathway in the Etiology of Major Mental Illnesses by Tomppo, Liisa, Hennah, William, Lahermo, Päivi, Loukola, Anu, Tuulio-Henriksson, Annamari, Suvisaari, Jaana, Partonen, Timo, Ekelund, Jesper, Lönnqvist, Jouko, Peltonen, Leena

“…Background Disrupted in Schizophrenia 1 (DISC1) is currently one of the most interesting candidate genes for major mental illness, having been demonstrated to…”
Get full text

Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci by Gupta, Richa, van Dongen, Jenny, Fu, Yu, Abdellaoui, Abdel, Tyndale, Rachel F, Velagapudi, Vidya, Boomsma, Dorret I, Korhonen, Tellervo, Kaprio, Jaakko, Loukola, Anu, Ollikainen, Miina

“…DNA methylation alteration extensively associates with smoking and is a plausible link between smoking and adverse health. We examined the association between…”
Get full text

A population-based association study of candidate genes for depression and sleep disturbance by Utge, Siddheshwar, Soronen, Pia, Partonen, Timo, Loukola, Anu, Kronholm, Erkki, Pirkola, Sami, Nyman, Emma, Porkka-Heiskanen, Tarja, Paunio, Tiina

“…The clinical manifestation of depression comprises a variety of symptoms, including early morning awakenings and fatigue, features also indicating disturbed…”
Get full text

Replication of Association Between Working Memory and Reelin , a Potential Modifier Gene in Schizophrenia by Wedenoja, Juho, Tuulio-Henriksson, Annamari, Suvisaari, Jaana, Loukola, Anu, Paunio, Tiina, Partonen, Timo, Varilo, Teppo, Lönnqvist, Jouko, Peltonen, Leena

“…Background The challenges in gene identification for psychiatric disorders have awakened interest toward quantitative traits and endophenotypes that are…”
Get full text

The association between DRD2/ANKK1 and genetically informed measures of alcohol use and problems by Meyers, Jacquelyn L., Nyman, Emma, Loukola, Anu, Rose, Richard J., Kaprio, Jaakko, Dick, Danielle M.

“…In 1990, Blum and colleagues first reported an association between DRD2 and alcoholism. While there have been subsequent replications of this genetic…”
Get full text

Population-Based Molecular Detection of Hereditary Nonpolyposis Colorectal Cancer by Salovaara, R, Loukola, A, Kristo, P, Kääriäinen, H, Ahtola, H, Eskelinen, M, Härkönen, N, Julkunen, R, Kangas, E, Ojala, S, Tulikoura, J, Valkamo, E, Järvinen, H, Mecklin, J P, Aaltonen, L A, de la Chapelle, A

“…Cancer morbidity and mortality can be dramatically reduced by colonoscopic screening of individuals with the hereditary nonpolyposis colorectal cancer (HNPCC)…”
Get full text

PTEN Mutational Spectra, Expression Levels, and Subcellular Localization in Microsatellite Stable and Unstable Colorectal Cancers by Zhou, Xiao-Ping, Loukola, Anu, Salovaara, Reijo, Nystrom-Lahti, Minna, Peltomäki, Päivi, de la Chapelle, Albert, Aaltonen, Lauri A., Eng, Charis

“…PTEN on 10q23.3 encodes a dual-specificity phosphatase that negatively regulates the phosphoinositol-3-kinase/Akt pathway and mediates cell-cycle arrest and…”
Get full text

Role of nicotine dependence in the association between the dopamine receptor gene DRD3 and major depressive disorder by Korhonen, Tellervo, Loukola, Anu, Wedenoja, Juho, Nyman, Emma, Latvala, Antti, Broms, Ulla, Häppölä, Anja, Paunio, Tiina, Schrage, Andrew J, Vink, Jaqueline M, Mbarek, Hamdi, Boomsma, Dorret I, Penninx, Brenda W J H, Pergadia, Michele L, Madden, Pamela A F, Kaprio, Jaakko

“…The aims of this study were to analyze associations of dopamine receptor genes (DRD1-5) with Major Depressive Disorder (MDD) and nicotine dependence (ND), and…”
Get full text

ADHD Candidate Gene Study in a Population-Based Birth Cohort: Association with DBH and DRD2 by NYMAN, EMMA S., M.Sc, OGDIE, MATTHEW N., Ph.D, LOUKOLA, ANU, Ph.D, VARILO, TEPPO, M.D, TAANILA, ANJA, Ph.D, HURTIG, TUULA, Ph.D, MOILANEN, IRMA K., M.D., Ph.D, LOO, SANDRA K., Ph.D, McGOUGH, JAMES J., M.D, JÄRVELIN, MARJO-RIITTA, M.D., Ph.D, SMALLEY, SUSAN L., Ph.D, NELSON, STANLEY F., M.D, PELTONEN, LEENA, M.D., Ph.D

“…ABSTRACT Objective Attention-deficit/hyperactivity disorder (ADHD) is a common childhood-onset disorder with a significant impact on public health. Although a…”
Get full text

The role of DTNBP1 , NRG1 , and AKT1 in the genetics of schizophrenia in Finland by Turunen, Joni A, Peltonen, Juho O, Pietiläinen, Olli P.H, Hennah, William, Loukola, Anu, Paunio, Tiina, Silander, Kaisa, Ekelund, Jesper, Varilo, Teppo, Partonen, Timo, Lönnqvist, Jouko, Peltonen, Leena

“…Abstract Several putative schizophrenia susceptibility genes have recently been identified. Significant associations between schizophrenia and neuregulin 1 (…”
Get full text

Interaction of early environment, gender and genes of monoamine neurotransmission in the aetiology of depression in a large population-based Finnish birth cohort by Nyman, Emma S, Sulkava, Sonja, Soronen, Pia, Miettunen, Jouko, Loukola, Anu, Leppä, Virpi, Joukamaa, Matti, Mäki, Pirjo, Järvelin, Marjo-Riitta, Freimer, Nelson, Peltonen, Leena, Veijola, Juha, Paunio, Tiina

“…ObjectivesDepression is a worldwide leading cause of morbidity and disability. Genetic studies have recently begun to elucidate its molecular aetiology. The…”
Get full text

Is Brain-Derived Neurotrophic Factor Associated With Smoking Initiation? Replication Using a Large Finnish Population Sample by Korhonen, Tellervo, Loukola, Anu, Hällfors, Jenni, Salomaa, Veikko, Kaprio, Jaakko

“…Abstract Introduction Brain-derived neurotrophic factor (BDNF) is a growth factor in the central nervous system. There is evidence for the involvement of BDNF…”
Get full text

The effect of body mass index on smoking behaviour and nicotine metabolism: a Mendelian randomization study by Taylor, Amy E, Richmond, Rebecca C, Palviainen, Teemu, Loukola, Anu, Wootton, Robyn E, Kaprio, Jaakko, Relton, Caroline L, Davey Smith, George, Munafò, Marcus R

“…Abstract Given clear evidence that smoking lowers weight, it is possible that individuals with higher body mass index (BMI) smoke in order to lose or maintain…”
Get full text

The I1307K polymorphism of the APC gene in colorectal cancer by Prior, Thomas W., Chadwick, Robert B., Papp, Audrey C., Arcot, Anuradha N., Isa, Alexandra M., Pearl, Dennis K., Stemmermann, Grant, Percesepe, Antonio, Loukola, Anu, Aaltonen, Lauri A., de la Chapelle, Albert

“…Background & Aims: Colorectal cancer is one of the most frequent cancers in humans. Recently, a germline missense mutation, I1307K, was identified in the…”
Get full text

FinnGen provides genetic insights from a well-phenotyped isolated population (vol 613, pg 508, 2023) by Kurki, MI, Karjalainen, J, Palta, P, Sipila, TP, Kristiansson, K, Donner, KM, Reeve, MP, Laivuori, H, Aavikko, M, Kaunisto, MA

Get full text

Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence by Hancock, D B, Guo, Y, Reginsson, G W, Gaddis, N C, Lutz, S M, Sherva, R, Loukola, A, Minica, C C, Markunas, C A, Han, Y, Young, K A, Gudbjartsson, D F, Gu, F, McNeil, D W, Qaiser, B, Glasheen, C, Olson, S, Landi, M T, Madden, P A F, Farrer, L A, Vink, J, Saccone, N L, Neale, M C, Kranzler, H R, McKay, J, Hung, R J, Amos, C I, Marazita, M L, Boomsma, D I, Baker, T B, Gelernter, J, Kaprio, J, Caporaso, N E, Thorgeirsson, T E, Hokanson, J E, Bierut, L J, Stefansson, K, Johnson, E O

“…Cigarette smoking is a leading cause of preventable mortality worldwide. Nicotine dependence, which reduces the likelihood of quitting smoking, is a heritable…”
Get full text