Search Results - "Louise Théroux"

Apolipoprotein E and lipid homeostasis in the etiology and treatment of sporadic Alzheimer's disease by Poirier, Judes, Miron, Justin, Picard, Cynthia, Gormley, Patrick, Théroux, Louise, Breitner, John, Dea, Doris

“…Abstract The discovery that the apolipoprotein E ( apoE ) ε4 allele is genetically linked to both sporadic and familial late-onset Alzheimer's disease (AD)…”
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Alterations in cholesterol metabolism–related genes in sporadic Alzheimer's disease by Picard, Cynthia, Julien, Cédric, Frappier, Josée, Miron, Justin, Théroux, Louise, Dea, Doris, Breitner, John C.S., Poirier, Judes

“…Genome-wide association studies have identified several cholesterol metabolism–related genes as top risk factors for late-onset Alzheimer's disease (LOAD). We…”
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Loss-of-Function PCSK9 Mutations Are Not Associated With Alzheimer Disease by Paquette, Martine, Saavedra, Yascara Grisel Luna, Poirier, Judes, Théroux, Louise, Dea, Doris, Baass, Alexis, Dufour, Robert

“…Background: Hypercholesterolemia is a major risk factor for the late-onset form of Alzheimer disease (AD). Loss-of-function (LOF) mutations of PCSK9 and PCSK9…”
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CDK5RAP2 gene and tau pathophysiology in late-onset sporadic Alzheimer's disease by Miron, Justin, Picard, Cynthia, Nilsson, Nathalie, Frappier, Josée, Dea, Doris, Théroux, Louise, Poirier, Judes

“…Because currently known Alzheimer's disease (AD) single-nucleotide polymorphisms only account for a small fraction of the genetic variance in this disease,…”
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Effects of rs3846662 Variants on HMGCR mRNA and Protein Levels and on Markers of Alzheimer’s Disease Pathology by Leduc, Valerie, Théroux, Louise, Dea, Doris, Dufour, Robert, Poirier, Judes

“…3-Hydroxy-3-methyglutaryl coenzyme A reductase (HMGCR) is a cholesterol-regulating gene with statin relevance. rs3846662 being involved in regulation of HMGCR…”
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Differential regulation of ABCA1 and ABCG1 gene expressions in the remodeling mouse hippocampus after entorhinal cortex lesion and liver-X receptor agonist treatment by Bélanger Jasmin, Stéphanie, Pearson, Vanessa, Lalonde, Daphnée, Domenger, Dorothée, Théroux, Louise, Poirier, Judes

“…Abstract Entorhinal cortex lesioning (ECL) causes an extensive deafferentation of the hippocampus that is classically followed by a compensatory reinnervation,…”
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Involvement of paraoxonase 1 genetic variants in Alzheimer's disease neuropathology by Leduc, Valérie, Théroux, Louise, Dea, Doris, Robitaille, Yves, Poirier, Judes

“…Evidence suggests that the genes involved in brain lipid homeostasis are of particular relevance for Alzheimer’s disease (AD) etiology. Among these genes, that…”
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A polymorphism in lipoprotein lipase affects the severity of Alzheimer's disease pathophysiology by Blain, Jean-François, Aumont, Nicole, Théroux, Louise, Dea, Doris, Poirier, Judes

“…Emerging evidences indicate a role for lipoprotein lipase (LPL) in degenerative states. Genetic variations in the LPL gene were previously associated to lipid…”
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Isoprenoids and tau pathology in sporadic Alzheimer's disease by Pelleieux, Sandra, Picard, Cynthia, Lamarre-Théroux, Louise, Dea, Doris, Leduc, Valérie, Tsantrizos, Youla S., Poirier, Judes

“…The mevalonate pathway has been described to play a key role in Alzheimer's disease (AD) physiopathology. Farnesyl pyrophosphate (FPP) and geranylgeranyl…”
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ISOPRENOIDS PATHWAY, TAU PHOSPHORYLATION AND ALZHEIMER’S DISEASE by Théroux, Louise, Pelleieux, Sandra, Tsantrizos, Youla, Dea, Doris, Poirier, Judes

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ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo by Burgess, Braydon L., Parkinson, Pamela F., Racke, Margaret M., Hirsch-Reinshagen, Veronica, Fan, Jianjia, Wong, Charmaine, Stukas, Sophie, Theroux, Louise, Chan, Jeniffer Y., Donkin, James, Wilkinson, Anna, Balik, Danielle, Christie, Brian, Poirier, Judes, Lütjohann, Dieter, DeMattos, Ronald B., Wellington, Cheryl L.

“…Cholesterol homeostasis is of emerging therapeutic importance for Alzheimer's disease (AD). Agonists of liver-X-receptors (LXRs) stimulate several genes that…”
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HMGCR is a genetic modifier for risk, age of onset and MCI conversion to Alzheimer’s disease in a three cohorts study by Leduc, V, De Beaumont, L, Théroux, L, Dea, D, Aisen, P, Petersen, R C, Dufour, R, Poirier, J

“…Several retrospective epidemiological studies report that utilization of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) inhibitors called statins at mid-life…”
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Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer’s disease is related to the apolipoprotein E genotype by Ramassamy, Charles, Averill, Diana, Beffert, Uwe, Bastianetto, Stephane, Theroux, Louise, Lussier-Cacan, Suzanne, Cohn, Jeffrey S, Christen, Yves, Davignon, Jean, Quirion, Rémi, Poirier, Judes

“…A great number of epidemiological studies have demonstrated that the frequency of the ε4 allele of the apolipoprotein E gene (APOE) is markedly higher in…”
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HMG COA REDUCTASE IS A GENETIC MODIFIER FOR RISK, AGE OF ONSET AND ALZHEIMER’S DISEASE’S CONVERSION WHICH MODULATES PATHOLOGY-RELATED AD BIOMARKERS by Dea, Doris, Théroux, Louise, Leduc, Valerie, Labonte, Anne, Nilsson, Nathalie I.V., Poirier, Judes

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CDK5RAP2 GENE AND TAU PATHOPHYSIOLOGY IN LATE-ONSET SPORADIC ALZHEIMER’S DISEASE by Miron, Justin, Picard, Cynthia, Frappier, Josée, Dea, Doris, Théroux, Louise, Nilsson, Nathalie I.V., Poirier, Judes

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SREBF2 POLYMORPHISMS AND EXPRESSION LEVELS CORRELATE WITH ALZHEIMER’S DISEASE NEUROPATHOLOGY by Picard, Cynthia, Julien, Cédric, Miron, Justin, Théroux, Louise, Dea, Doris, Poirier, Judes

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Butyrylcholinesterase K and Apolipoprotein E-ɛ4 Reduce the Age of Onset of Alzheimer's Disease, Accelerate Cognitive Decline, and Modulate Donepezil Response in Mild Cognitively Impaired Subjects by De Beaumont, Louis, Pelleieux, Sandra, Lamarre-Théroux, Louise, Dea, Doris, Poirier, Judes

“…Genetic heterogeneity in amnestic mild cognitively impaired (aMCI) subjects could lead to variations in progression rates and response to cholinomimetic…”
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Oxidative Insults Are Associated with Apolipoprotein E Genotype in Alzheimer's Disease Brain by Ramassamy, Charles, Averill, Diana, Beffert, Uwe, Theroux, Louise, Lussier-Cacan, Suzanne, Cohn, Jeffrey S., Christen, Yves, Schoofs, Alain, Davignon, Jean, Poirier, Judes

“…The ϵ4 allele of the apolipoprotein E gene (APOE) is associated with sporadic and familial late-onset Alzheimer's disease (AD). Oxidative stress is believed to…”
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P2‐069: Central auditory processing in individuals at risk for Alzheimer's dementia by Tuwaig, Miranda, Savard, Mélissa, Jutras, Benoît, Lamarre-Théroux, Louise, Poirier, Judes, Breitner, John C.S.

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Central auditory processing in individuals at risk for Alzheimer’s dementia by Tuwaig, Miranda, Savard, Mélissa, Jutras, Benoît, Lamarre-Théroux, Louise, Poirier, Judes, Breitner, John C.S

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