Search Results - "Louise Meadows, Mary"
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Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells
Published in Redox biology (01-12-2015)“…ATP is essential for cellular function and is usually produced through oxidative phosphorylation. However, mitochondrial dysfunction is now being recognized as…”
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PDZ‐Binding Kinase Drives Pulmonary Artery Smooth Muscle Proliferation and Vascular Remodeling in Pulmonary Arterial Hypertension
Published in The FASEB journal (01-05-2022)“…Pulmonary Arterial Hypertension (PAH) is a progressive disease that is caused by high blood pressure in the lungs that originates from increased resistance of…”
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3
Endothelin-1 induces a glycolytic switch in pulmonary arterial endothelial cells via the mitochondrial translocation of endothelial nitric oxide synthase
Published in American journal of respiratory cell and molecular biology (01-06-2014)“…Recent studies have indicated that, during the development of pulmonary hypertension (PH), there is a switch from oxidative phosphorylation to glycolysis in…”
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4
Endothelial nitric oxide synthase deficient mice are protected from lipopolysaccharide induced acute lung injury
Published in PloS one (18-03-2015)“…Lipopolysaccharide (LPS) derived from the outer membrane of gram-negative bacteria induces acute lung injury (ALI) in mice. This injury is associated with lung…”
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5
GAL3 Excretion Regulates Smooth Muscle Cell Survival and Proliferation
Published in The FASEB journal (01-05-2022)“…Pulmonary arterial hypertension (PAH) is a complex and fatal disorder characterized by an unrelenting increase in pulmonary arterial pressure. Excessive…”
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6
Galectin 3 secretion in pulmonary arterial hypertension
Published in Physiology (Bethesda, Md.) (01-05-2023)“…Abstract only Pulmonary arterial hypertension (PAH) is a complex and fatal disorder characterized by an unrelenting increase in pulmonary arterial pressure…”
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Investigating the Metabolic and Epigenetic Roles of PBK in Pulmonary Arterial Hypertension
Published in Free radical biology & medicine (01-11-2024)Get full text
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Hematopoietic Cell Galectin-3 as a Driver of Vascular Remodeling in Pulmonary Hypertension
Published in Free radical biology & medicine (01-11-2024)Get full text
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9
GAL3 Regulates Smooth Muscle Cell Survival in PAH via its NWGR Motif
Published in The FASEB journal (01-04-2020)“…Abstract only Pulmonary arterial hypertension (PAH) is a complex and fatal disorder characterized by an unrelenting increase in pulmonary arterial pressure…”
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10
Endothelin-1 acutely increases nitric oxide production via the calcineurin mediated dephosphorylation of Caveolin-1
Published in Nitric oxide (01-11-2023)“…Endothelin (ET)-1 is an endothelial-derived peptide that exerts biphasic effects on nitric oxide (NO) levels in endothelial cells such that acute exposure…”
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11
Adenosine and ATPγS protect against bacterial pneumonia-induced acute lung injury
Published in Scientific reports (22-10-2020)“…Lipopolysaccharide (LPS), a component of the outer membrane of gram-negative bacteria, disrupts the alveolar-capillary barrier, triggering pulmonary vascular…”
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PDZ-Binding Kinase, a Novel Regulator of Vascular Remodeling in Pulmonary Arterial Hypertension
Published in Circulation (New York, N.Y.) (30-07-2024)“…Pulmonary arterial hypertension (PAH) is high blood pressure in the lungs that originates from structural changes in small resistance arteries. A defining…”
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13
PBK is a Novel Regulator of Vascular Remodeling in Pulmonary Arterial Hypertension
Published in The FASEB journal (01-04-2020)“…Abstract only Pulmonary Arterial Hypertension (PAH) is an insidious disease that develops gradually and becomes symptomatic only in the latter stages. In PAH,…”
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14
Histone Deacetylase Inhibitors Suppress Transcription of NADPH Oxidases and Ameliorate Pulmonary Hypertension
Published in The FASEB journal (01-04-2016)“…Abstract only Excessive production of reactive oxygen species (ROS) have been shown to be detrimental in cardiovascular disease as well as many other…”
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313 - Complex I Dysfunction Dictates Glycolytic Switch in Pulmonary Hypertensive Smooth Muscle Cells
Published in Free radical biology & medicine (01-10-2015)Get full text
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Complex I Dysfunction Dictates Glycolytic Switch in Pulmonary Hypertensive Smooth Muscle Cells
Published in Free radical biology & medicine (01-10-2015)Get full text
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17
The sexual dimorphism associated with pulmonary hypertension corresponds to a fibrotic phenotype
Published in Pulmonary circulation (01-03-2015)“…Although female predominance in the development of all types of pulmonary hypertension (PH) is well established, many clinical studies have confirmed that…”
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