Search Results - "Louis H. Philipson"

The Mental Health Comorbidities of Diabetes by Ducat, Lee, Philipson, Louis H, Anderson, Barbara J

“…Individuals living with type 1 or type 2 diabetes are at increased risk for depression, anxiety, and eating disorder diagnoses. Mental health comorbidities of…”
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Precision diabetes: Lessons learned from maturity‐onset diabetes of the young (MODY) by Tosur, Mustafa, Philipson, Louis H

“…Maturity‐onset of diabetes of the young (MODY) are monogenic forms of diabetes characterized by early onset diabetes with autosomal dominant inheritance. Since…”
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Monogenic Diabetes in Children and Adolescents: Recognition and Treatment Options by Sanyoura, May, Philipson, Louis H., Naylor, Rochelle

“…Purpose of Review We provide a review of monogenic diabetes in young children and adolescents with a focus on recognition, management, and pharmacological…”
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Intracellular transport of insulin granules is a subordinated random walk by Tabei, S. M. Ali, Burov, Stanislav, Kim, Hee Y., Kuznetsov, Andrey, Huynh, Toan, Jureller, Justin, Philipson, Louis H., Dinner, Aaron R., Scherer, Norbert F.

“…We quantitatively analyzed particle tracking data on insulin granules expressing fluorescent fusion proteins in MIN6 cells to better understand the motions…”
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Update on Diabetes Classification by Thomas, Celeste C., MD, MS, Philipson, Louis H., MD, PhD

“…Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The…”
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Integrated Pancreatic Blood Flow: Bidirectional Microcirculation Between Endocrine and Exocrine Pancreas by Dybala, Michael P, Kuznetsov, Andrey, Motobu, Maki, Hendren-Santiago, Bryce K, Philipson, Louis H, Chervonsky, Alexander V, Hara, Manami

“…The pancreatic islet is a highly vascularized endocrine micro-organ. The unique architecture of rodent islets, a so-called core-mantle arrangement seen in…”
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Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes by Bass, Joseph, Marcheva, Biliana, Ramsey, Kathryn Moynihan, Buhr, Ethan D, Kobayashi, Yumiko, Su, Hong, Ko, Caroline H, Ivanova, Ganka, Omura, Chiaki, Mo, Shelley, Vitaterna, Martha H, Lopez, James P, Philipson, Louis H, Bradfield, Christopher A, Crosby, Seth D, JeBailey, Lellean, Wang, Xiaozhong, Takahashi, Joseph S

“…The molecular clock maintains energy constancy by producing circadian oscillations of rate-limiting enzymes involved in tissue metabolism across the day and…”
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Monogenic Diabetes: From Genetic Insights to Population-Based Precision in Care. Reflections From a Diabetes Care Editors' Expert Forum by Riddle, Matthew C, Philipson, Louis H, Rich, Stephen S, Carlsson, Annelie, Franks, Paul W, Greeley, Siri Atma W, Nolan, John J, Pearson, Ewan R, Zeitler, Philip S, Hattersley, Andrew T

“…Individualization of therapy based on a person's specific type of diabetes is one key element of a "precision medicine" approach to diabetes care. However,…”
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α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes by Brissova, Marcela, Haliyur, Rachana, Saunders, Diane, Shrestha, Shristi, Dai, Chunhua, Blodgett, David M., Bottino, Rita, Campbell-Thompson, Martha, Aramandla, Radhika, Poffenberger, Gregory, Lindner, Jill, Pan, Fong Cheng, von Herrath, Matthias G., Greiner, Dale L., Shultz, Leonard D., Sanyoura, May, Philipson, Louis H., Atkinson, Mark, Harlan, David M., Levy, Shawn E., Prasad, Nripesh, Stein, Roland, Powers, Alvin C.

“…Many patients with type 1 diabetes (T1D) have residual β cells producing small amounts of C-peptide long after disease onset but develop an inadequate glucagon…”
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The Role of β Cell Glucagon-like Peptide-1 Signaling in Glucose Regulation and Response to Diabetes Drugs by Smith, Eric P., An, Zhibo, Wagner, Constance, Lewis, Alfor G., Cohen, Eric B., Li, Bailing, Mahbod, Parinaz, Sandoval, Darleen, Perez-Tilve, Diego, Tamarina, Natalia, Philipson, Louis H., Stoffers, Doris A., Seeley, Randy J., D’Alessio, David A.

“…Glucagon-like peptide-1 (GLP-1), an insulinotropic gut peptide released after eating, is essential for normal glucose tolerance (GT). To determine whether this…”
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Diabetes Presentation in Infancy: High Risk of Diabetic Ketoacidosis by Letourneau, Lisa R, Carmody, David, Wroblewski, Kristen, Denson, Anna M, Sanyoura, May, Naylor, Rochelle N, Philipson, Louis H, Greeley, Siri Atma W

“…Diabetes in childhood has been associated with increased morbidity and mortality, but the risks for diabetes in infancy remain unclear. Cases with onset of…”
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The Brain-to-Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions by Rosario, Wilfredo, Singh, Inderroop, Wautlet, Arnaud, Patterson, Christa, Flak, Jonathan, Becker, Thomas C, Ali, Almas, Tamarina, Natalia, Philipson, Louis H, Enquist, Lynn W, Myers, Jr, Martin G, Rhodes, Christopher J

“…The brain influences glucose homeostasis, partly by supplemental control over insulin and glucagon secretion. Without this central regulation, diabetes and its…”
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Pancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational Analysis by Fridlyand, Leonid E, Philipson, Louis H

“…Insulin secretory in pancreatic beta-cells responses to nutrient stimuli and hormonal modulators include multiple messengers and signaling pathways with…”
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Kv2.1 Ablation Alters Glucose-Induced Islet Electrical Activity, Enhancing Insulin Secretion by Jacobson, David A., Kuznetsov, Andrey, Lopez, James P., Kash, Shera, Ämmälä, Carina E., Philipson, Louis H.

“…Voltage-gated potassium currents (Kv), primarily due to Kv2.1 channels, are activated by glucose-stimulated pancreatic β cell depolarization, but the exact…”
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Functional Role of Serotonin in Insulin Secretion in a Diet-Induced Insulin-Resistant State by Kim, Kyuho, Oh, Chang-Myung, Ohara-Imaizumi, Mica, Park, Sangkyu, Namkung, Jun, Yadav, Vijay K, Tamarina, Natalia A, Roe, Michael W, Philipson, Louis H, Karsenty, Gerard, Nagamatsu, Shinya, German, Michael S, Kim, Hail

“…The physiological role of serotonin, or 5-hydroxytryptamine (5-HT), in pancreatic β-cell function was previously elucidated using a pregnant mouse model…”
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Distribution of directional change as a signature of complex dynamics by Burov, Stanislav, Tabei, S. M. Ali, Huynh, Toan, Murrell, Michael P., Philipson, Louis H., Rice, Stuart A., Gardel, Margaret L., Scherer, Norbert F., Dinner, Aaron R.

“…Analyses of random walks traditionally use the mean square displacement (MSD) as an order parameter characterizing dynamics. We show that the distribution of…”
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Who should have genetic testing for maturity-onset diabetes of the young? by Naylor, Rochelle, Philipson, Louis H.

“…Summary Maturity‐onset diabetes of the young (MODY) is a clinically heterogeneous group of monogenic disorders characterized by autosomal dominant inheritance…”
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Type 2 Diabetes and Congenital Hyperinsulinism Cause DNA Double-Strand Breaks and p53 Activity in β Cells by Tornovsky-Babeay, Sharona, Dadon, Daniela, Ziv, Oren, Tzipilevich, Elhanan, Kadosh, Tehila, Schyr-Ben Haroush, Rachel, Hija, Ayat, Stolovich-Rain, Miri, Furth-Lavi, Judith, Granot, Zvi, Porat, Shay, Philipson, Louis H., Herold, Kevan C., Bhatti, Tricia R., Stanley, Charles, Ashcroft, Frances M., In’t Veld, Peter, Saada, Ann, Magnuson, Mark A., Glaser, Benjamin, Dor, Yuval

“…β cell failure in type 2 diabetes (T2D) is associated with hyperglycemia, but the mechanisms are not fully understood. Congenital hyperinsulinism caused by…”
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Age at the time of sulfonylurea initiation influences treatment outcomes in KCNJ11-related neonatal diabetes by Thurber, Brian W., Carmody, David, Tadie, Elizabeth C., Pastore, Ashley N., Dickens, Jazzmyne T., Wroblewski, Kristen E., Naylor, Rochelle N., Philipson, Louis H., Greeley, Siri Atma W.

“…Aims/hypothesis Individuals with heterozygous activating mutations of the KCNJ11 gene encoding a subunit of the ATP-sensitive potassium channel (KATP) can…”
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chemistrode: A droplet-based microfluidic device for stimulation and recording with high temporal, spatial, and chemical resolution by Chen, Delai, Du, Wenbin, Liu, Ying, Liu, Weishan, Kuznetsov, Andrey, Mendez, Felipe E, Philipson, Louis H, Ismagilov, Rustem F

“…Microelectrodes enable localized electrical stimulation and recording, and they have revolutionized our understanding of the spatiotemporal dynamics of systems…”
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