Search Results - "Louis Bourgeois, A."

Enterotoxigenic Escherichia coli (ETEC) vaccines: Priority activities to enable product development, licensure, and global access by Khalil, Ibrahim, Walker, Richard, Porter, Chad K., Muhib, Farzana, Chilengi, Roma, Cravioto, Alejandro, Guerrant, Richard, Svennerholm, Ann-Mari, Qadri, Firdausi, Baqar, Shahida, Kosek, Margaret, Kang, Gagandeep, Lanata, Claudio, Armah, George, Wierzba, Thomas, Hasso-Agopsowicz, Mateusz, Giersing, Birgitte, Louis Bourgeois, A.

“…Diarrhoeal disease attributable to enterotoxigenic Escherichia coli (ETEC) causes substantial morbidity and mortality predominantly in paediatric populations…”
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Live attenuated enterotoxigenic Escherichia coli (ETEC) vaccine with dmLT adjuvant protects human volunteers against virulent experimental ETEC challenge by Harro, Clayton, Louis Bourgeois, A, Sack, David, Walker, Richard, DeNearing, Barbara, Brubaker, Jessica, Maier, Nicole, Fix, Alan, Dally, Len, Chakraborty, Subhra, Clements, John D, Saunders, Ingelise, Darsley, Michael J

“…AbstractBackgroundThere is no licensed vaccine against enterotoxigenic Escherichia coli (ETEC), a major cause of diarrhea-associated morbidity and mortality…”
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Status of vaccine research and development for enterotoxigenic Escherichia coli by Bourgeois, A. Louis, Wierzba, Thomas F, Walker, Richard I

“…Highlights • ETEC is a top cause of diarrhea in children and travelers to low-resource countries. • Models suggest ETEC vaccines would be cost-effective and…”
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Safety and immunogenicity of intramuscularly administered CS6 subunit vaccine with a modified heat-labile enterotoxin from enterotoxigenic Escherichia coli by Lee, Tida, Gutiérrez, Ramiro L., Maciel, Milton, Poole, Steven, Testa, Kayla J., Trop, Stefanie, Duplessis, Christopher, Lane, Alison, Riddle, Mark S., Hamer, Melinda, Alcala, Ashley, Prouty, Michael, Maier, Nicole, Erdem, Rahsan, Louis Bourgeois, A., Porter, Chad K.

“…Enterotoxigenic Escherichia coli (ETEC) is a common cause of infectious diarrhoea and a leading cause of morbidity and mortality in children living in…”
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Challenges and opportunities in developing a Shigella-containing combination vaccine for children in low- and middle-income countries: Report of an expert convening by Riddle, Mark S., Louis Bourgeois, A., Clifford, Allison, Jeon, Suhi, Giersing, Birgitte K., Jit, Mark, Tufet Bayona, Marta, Ovitt, Jared, Hausdorff, William P.

“…The gram-negative bacterium Shigella is an enteric pathogen responsible for significant morbidity and mortality due primarily to severe diarrhea and dysentery,…”
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Induction of mucosal and systemic immune responses against the common O78 antigen of an oral inactivated ETEC vaccine in Bangladeshi children and infants by Svennerholm, Ann-Mari, Qadri, Firdausi, Lundgren, Anna, Kaim, Joanna, Rahman Bhuiyan, Taufiqur, Akhtar, Marjahan, Maier, Nicole, Louis Bourgeois, A., Walker, Richard I.

“…We tested an oral enterotoxigenic Escherichia coli (ETEC) vaccine, ETVAX, consisting of inactivated E. coli overexpressing the most prevalent ETEC colonization…”
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Oral inactivated whole cell vaccine for mucosal immunization: ETVAX case study by Walker, Richard I, Bourgeois, A Louis

“…Oral immunization is an effective strategy for inducing protective immunity against mucosal enteric pathogens. Although live-attenuated as well as subunit…”
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The 2022 Vaccines Against Shigella and Enterotoxigenic Escherichia coli (VASE) Conference: Summary of abstract-based presentations by Banerjee, Soumalya, Barry, Eileen M., Baqar, Shahida, Louis Bourgeois, A., Campo, Joseph J., Choy, Robert K.M., Chakraborty, Subhra, Clifford, Allison, Deal, Carolyn, Estrada, Marcus, Fleckenstein, James, Hasso-Agopsowicz, Mateusz, Hausdorff, William, Khalil, Ibrahim, Maier, Nicole, Mubanga, Cynthia, Platts-Mills, James A., Porter, Chad, Qadri, Firadausi, Simuyandi, Michelo, Walker, Richard, White, Jessica A.

“…•The third Vaccines Against Shigella and ETEC (VASE) Conference was in Nov. 2022.•Enteric diseases are a substantial public health burden in low-resource…”
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Developing and utilizing controlled human models of infection by Porter, Chad K, Louis Bourgeois, A, Frenck, Robert W, Prouty, Michael, Maier, Nicole, Riddle, Mark S

“…Abstract The controlled human infection model (CHIM) to assess the efficacy of vaccines against Shigella and enterotoxigenic Escherichia coli (ETEC) has…”
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The 2022 Vaccines Against Shigella and Enterotoxigenic Escherichia coli (VASE) Conference: Summary of breakout workshops by Baqar, Shahida, Bonavia, Aurelio, Louis Bourgeois, A., Campo, Joseph J., Clifford, Allison, Hanevik, Kurt, Hasso-Agopsowicz, Mateusz, Hausdorff, William, Kaminski, Robert, MacLennan, Calman A., Mantis, Nicholas, Martin, Laura B., Omore, Richard, Pasetti, Marcela, Pavlinac, Patricia, Phalipon, Armelle, Poly, Frédéric, Porter, Chad, Ramasamy, Maheshi N., Rogawski McQuade, Elizabeth T., Sztein, Marcelo B., Walker, Richard

“…•Economic evaluations of enteric vaccine impact will help guide health investments.•Advancing adjuvant-vaccine combinations to human clinical trials is…”
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Consensus Report on Shigella Controlled Human Infection Model: Immunological Assays by Kaminski, Robert W, Pasetti, Marcela F, Aguilar, Ana Older, Clarkson, Kristen A, Rijpkema, Sjoerd, Bourgeois, A Louis, Cohen, Dani, Feavers, Ian, MacLennan, Calman A

“…Abstract Moderate to severe diarrhea caused by Shigella is a global health concern due to its substantial contribution to morbidity and mortality in children…”
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Consensus Report on Shigella Controlled Human Infection Model: Clinical Endpoints by MacLennan, Calman A, Riddle, Mark S, Chen, Wilbur H, Talaat, Kawsar R, Jain, Varsha, Bourgeois, A Louis, Frenck, Robert, Kotloff, Karen, Porter, Chad K

“…Abstract The Shigella controlled human infection model (CHIM) is valuable for assessing candidate Shigella vaccine efficacy and potentially accelerating…”
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Intestinal and systemic inflammation induced by symptomatic and asymptomatic enterotoxigenic E. coli infection and impact on intestinal colonization and ETEC specific immune responses in an experimental human challenge model by Brubaker, Jessica, Zhang, Xueyan, Bourgeois, A. Louis, Harro, Clayton, Sack, David A, Chakraborty, Subhra

“…Recent studies have gained a better appreciation of the potential impacts of enteric infections beyond symptomatic diarrhea. It is recognized that infections…”
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Consensus Report on Shigella Controlled Human Infection Model: Conduct of Studies by Talaat, Kawsar R, Bourgeois, A Louis, Frenck, Robert W, Chen, Wilbur H, MacLennan, Calman A, Riddle, Mark S, Suvarnapunya, Akamol E, Brubaker, Jessica L, Kotloff, Karen L, Porter, Chad K

“…Abstract Shigella causes morbidity and mortality worldwide, primarily affecting young children living in low-resource settings. It is also of great concern due…”
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Evaluation of the reactogenicity, adjuvanticity and antigenicity of LT(R192G) and LT(R192G/L211A) by intradermal immunization in mice by Maciel, Jr, Milton, Smith, Mark, Poole, Steven T, Laird, Renee M, Rollenhagen, Julianne E, Kaminski, Robert W, Wenzel, Heather, Bourgeois, A Louis, Savarino, Stephen J

“…The development of an effective subunit vaccine is frequently complicated by the difficulty of eliciting protective immune responses, often requiring the…”
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Estimating diarrheal illness and deaths attributable to Shigellae and enterotoxigenic Escherichia coli among older children, adolescents, and adults in South Asia and Africa by Lamberti, Laura M, Bourgeois, A Louis, Fischer Walker, Christa L, Black, Robert E, Sack, David

“…While Shigellae and strains of enterotoxigenic Escherichia coli (ETEC) are important causes of diarrhea-associated morbidity and mortality among infants and…”
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The Oral, Live Attenuated Enterotoxigenic Escherichia coli Vaccine ACE527 Reduces the Incidence and Severity of Diarrhea in a Human Challenge Model of Diarrheal Disease by Darsley, Michael J, Chakraborty, Subhra, DeNearing, Barbara, Sack, David A, Feller, Andrea, Buchwaldt, Charlotte, Bourgeois, A Louis, Walker, Richard, Harro, Clayton D

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Human challenge study with a Shigella bioconjugate vaccine: Analyses of clinical efficacy and correlate of protection by Talaat, Kawsar R., Alaimo, Cristina, Martin, Patricia, Bourgeois, A. Louis, Dreyer, Anita M., Kaminski, Robert W., Porter, Chad K., Chakraborty, Subhra, Clarkson, Kristen A., Brubaker, Jessica, Elwood, Daniel, Frölich, Rahel, DeNearing, Barbara, Weerts, Hailey, Feijoo, Brittany L., Halpern, Jane, Sack, David, Riddle, Mark S., Fonck, Veronica Gambillara

“…Shigellosis is a major cause of moderate to severe diarrhoea and dysentery in children under 5 years of age in low and middle-income countries. The Flexyn2a…”
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Adjuvant effect of enterotoxigenic Escherichia coli (ETEC) double-mutant heat-labile toxin (dmLT) on systemic immunogenicity induced by the CFA/I/II/IV MEFA ETEC vaccine: Dose-related enhancement of antibody responses to seven ETEC adhesins (CFA/I, CS1-CS6) by Seo, Hyesuk, Lu, Ti, Mani, Sachin, Bourgeois, A. Louis, Walker, Richard, Sack, David A., Zhang, Weiping

“…Double-mutant heat-labile toxin (dmLT, LT R192G/L211A ) of enterotoxigenic Escherichia coli (ETEC) is an effective mucosal adjuvant. Recent studies have shown…”
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Clinical endpoints in the controlled human challenge model for Shigella: A call for standardization and the development of a disease severity score by Porter, Chad K, Lynen, Amanda, Riddle, Mark S, Talaat, Kawsar, Sack, David, Gutiérrez, Ramiro L, McKenzie, Robin, DeNearing, Barbara, Feijoo, Brittany, Kaminski, Robert W, Taylor, David N, Kirkpatrick, Beth D, Bourgeois, A Louis

“…Since 1946 the controlled human infection model (CHIM) for Shigella has been used to improve understanding of disease pathogenesis, describe clinical and…”
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