Search Results - "Louis, David N"

A vade mecum for crossing the second translational “valley of death” in brain tumor classification by Louis, David N.

“…The earlier editions were nearly entirely definitions, with brief descriptions and scant illustrations, but more recent Blue Books are extensive textbooks in…”
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The 2021 WHO Classification of Tumors of the Central Nervous System: a summary by Louis, David N, Perry, Arie, Wesseling, Pieter, Brat, Daniel J, Cree, Ian A, Figarella-Branger, Dominique, Hawkins, Cynthia, Ng, H K, Pfister, Stefan M, Reifenberger, Guido, Soffietti, Riccardo, von Deimling, Andreas, Ellison, David W

“…Abstract The fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS), published in 2021, is the sixth version of the…”
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Molecular pathology of malignant gliomas by Louis, David N

“…Malignant gliomas, the most common type of primary brain tumor, are a spectrum of tumors of varying differentiation and malignancy grades. These tumors may…”
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The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary by Louis, David N., Perry, Arie, Reifenberger, Guido, von Deimling, Andreas, Figarella-Branger, Dominique, Cavenee, Webster K., Ohgaki, Hiroko, Wiestler, Otmar D., Kleihues, Paul, Ellison, David W.

“…The 2016 World Health Organization Classification of Tumors of the Central Nervous System is both a conceptual and practical advance over its 2007 predecessor…”
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cIMPACT‐NOW update 7: advancing the molecular classification of ependymal tumors by Ellison, David W., Aldape, Kenneth D., Capper, David, Fouladi, Maryam, Gilbert, Mark R., Gilbertson, Richard J., Hawkins, Cynthia, Merchant, Thomas E., Pajtler, Kristian, Venneti, Sriram, Louis, David N.

“…Advances in our understanding of the biological basis and molecular characteristics of ependymal tumors since the latest iteration of the World Health…”
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Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells by Suvà, Mario L., Rheinbay, Esther, Gillespie, Shawn M., Patel, Anoop P., Wakimoto, Hiroaki, Rabkin, Samuel D., Riggi, Nicolo, Chi, Andrew S., Cahill, Daniel P., Nahed, Brian V., Curry, William T., Martuza, Robert L., Rivera, Miguel N., Rossetti, Nikki, Kasif, Simon, Beik, Samantha, Kadri, Sabah, Tirosh, Itay, Wortman, Ivo, Shalek, Alex K., Rozenblatt-Rosen, Orit, Regev, Aviv, Louis, David N., Bernstein, Bradley E.

“…Developmental fate decisions are dictated by master transcription factors (TFs) that interact with cis-regulatory elements to direct transcriptional programs…”
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Mosaic Amplification of Multiple Receptor Tyrosine Kinase Genes in Glioblastoma by Snuderl, Matija, Fazlollahi, Ladan, Le, Long P., Nitta, Mai, Zhelyazkova, Boryana H., Davidson, Christian J., Akhavanfard, Sara, Cahill, Daniel P., Aldape, Kenneth D., Betensky, Rebecca A., Louis, David N., Iafrate, A. John

“…Tumor heterogeneity has been implicated in tumor growth and progression as well as resistance to therapy. We present an example of genetic heterogeneity in…”
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Molecular pathology in adult gliomas: diagnostic, prognostic, and predictive markers by Jansen, Michael, MBBCh, Yip, Stephen, MD, Louis, David N, Prof

“…Summary Over the past 10 years, there has been an increasing use of molecular markers in the assessment and management of adult malignant gliomas. Some…”
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Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma by Patel, Anoop P., Tirosh, Itay, Trombetta, John J., Shalek, Alex K., Gillespie, Shawn M., Wakimoto, Hiroaki, Cahill, Daniel P., Nahed, Brian V., Curry, William T., Martuza, Robert L., Louis, David N., Rozenblatt-Rosen, Orit, Suvà, Mario L., Regev, Aviv, Bernstein, Bradley E.

“…Human cancers are complex ecosystems composed of cells with distinct phenotypes, genotypes, and epigenetic states, but current models do not adequately reflect…”
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The 2016 WHO classification of central nervous system tumors: what neurologists need to know by DeWitt, John C, Mock, Andreas, Louis, David N

“…The 2016 WHO classification of tumors of the central nervous system (2016 CNS WHO) features many changes that are relevant to neurologists treating patients…”
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The Diagnostic Use of Immunohistochemical Surrogates for Signature Molecular Genetic Alterations in Gliomas by Tanboon, Jantima, Williams, Erik A., Louis, David N.

“…A number of key mutations that affect treatment and prognosis have been identified in human gliomas. Two major ways to identify these mutations in a tumor…”
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Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma by Schindler, Genevieve, Capper, David, Meyer, Jochen, Janzarik, Wibke, Omran, Heymut, Herold-Mende, Christel, Schmieder, Kirsten, Wesseling, Pieter, Mawrin, Christian, Hasselblatt, Martin, Louis, David N., Korshunov, Andrey, Pfister, Stefan, Hartmann, Christian, Paulus, Werner, Reifenberger, Guido, von Deimling, Andreas

“…Missense mutations of the V600E type constitute the vast majority of tumor-associated somatic alterations in the v-RAF murine sarcoma viral oncogene homolog B1…”
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International Society of Neuropathology-Haarlem Consensus Guidelines for Nervous System Tumor Classification and Grading by Louis, David N., Perry, Arie, Burger, Peter, Ellison, David W., Reifenberger, Guido, von Deimling, Andreas, Aldape, Kenneth, Brat, Daniel, Collins, V. Peter, Eberhart, Charles, Figarella-Branger, Dominique, Fuller, Gregory N., Giangaspero, Felice, Giannini, Caterina, Hawkins, Cynthia, Kleihues, Paul, Korshunov, Andrey, Kros, Johan M., Beatriz Lopes, M., Ng, Ho-Keung, Ohgaki, Hiroko, Paulus, Werner, Pietsch, Torsten, Rosenblum, Marc, Rushing, Elisabeth, Soylemezoglu, Figen, Wiestler, Otmar, Wesseling, Pieter

“…Major discoveries in the biology of nervous system tumors have raised the question of how non‐histological data such as molecular information can be…”
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Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations by Brastianos, Priscilla K, Horowitz, Peleg M, Santagata, Sandro, Jones, Robert T, McKenna, Aaron, Getz, Gad, Ligon, Keith L, Palescandolo, Emanuele, Van Hummelen, Paul, Ducar, Matthew D, Raza, Alina, Sunkavalli, Ashwini, MacConaill, Laura E, Stemmer-Rachamimov, Anat O, Louis, David N, Hahn, William C, Dunn, Ian F, Beroukhim, Rameen

“…Rameen Beroukhim, Ian Dunn, William Hahn and colleagues report genome and exome sequencing of meningiomas. They identified recurrent somatic mutations in AKT1…”
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Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells by Ozkumur, Emre, Shah, Ajay M, Ciciliano, Jordan C, Emmink, Benjamin L, Miyamoto, David T, Brachtel, Elena, Yu, Min, Chen, Pin-i, Morgan, Bailey, Trautwein, Julie, Kimura, Anya, Sengupta, Sudarshana, Stott, Shannon L, Karabacak, Nezihi Murat, Barber, Thomas A, Walsh, John R, Smith, Kyle, Spuhler, Philipp S, Sullivan, James P, Lee, Richard J, Ting, David T, Luo, Xi, Shaw, Alice T, Bardia, Aditya, Sequist, Lecia V, Louis, David N, Maheswaran, Shyamala, Kapur, Ravi, Haber, Daniel A, Toner, Mehmet

“…Circulating tumor cells (CTCs) are shed into the bloodstream from primary and metastatic tumor deposits. Their isolation and analysis hold great promise for…”
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Dramatic Response of BRAF V600E Mutant Papillary Craniopharyngioma to Targeted Therapy by Brastianos, Priscilla K, Shankar, Ganesh M, Gill, Corey M, Taylor-Weiner, Amaro, Nayyar, Naema, Panka, David J, Sullivan, Ryan J, Frederick, Dennie T, Abedalthagafi, Malak, Jones, Pamela S, Dunn, Ian F, Nahed, Brian V, Romero, Javier M, Louis, David N, Getz, Gad, Cahill, Daniel P, Santagata, Sandro, Curry, Jr, William T, Barker, 2nd, Fred G

“…We recently reported that BRAF V600E is the principal oncogenic driver of papillary craniopharyngioma, a highly morbid intracranial tumor commonly refractory…”
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Grading of diffuse astrocytic gliomas: Broders, Kernohan, Zülch, the WHO… and Shakespeare by Louis, David N., von Deimling, Andreas

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cIMPACT‐NOW: a practical summary of diagnostic points from Round 1 updates by Louis, David N., Ellison, David W., Brat, Daniel J., Aldape, Kenneth, Capper, David, Hawkins, Cynthia, Paulus, Werner, Perry, Arie, Reifenberger, Guido, Figarella‐Branger, Dominique, Deimling, Andreas, Wesseling, Pieter

“…cIMPACT‐NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy) was established to provide a forum to evaluate and recommend…”
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BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications by Dias-Santagata, Dora, Lam, Quynh, Vernovsky, Kathy, Vena, Natalie, Lennerz, Jochen K, Borger, Darrell R, Batchelor, Tracy T, Ligon, Keith L, Iafrate, A John, Ligon, Azra H, Louis, David N, Santagata, Sandro

“…Pleomorphic xanthoastrocytoma (PXA) is low-grade glial neoplasm principally affecting children and young adults. Approximately 40% of PXA are reported to recur…”
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An Aberrant Transcription Factor Network Essential for Wnt Signaling and Stem Cell Maintenance in Glioblastoma by Rheinbay, Esther, Suvà, Mario L., Gillespie, Shawn M., Wakimoto, Hiroaki, Patel, Anoop P., Shahid, Mohammad, Oksuz, Ozgur, Rabkin, Samuel D., Martuza, Robert L., Rivera, Miguel N., Louis, David N., Kasif, Simon, Chi, Andrew S., Bernstein, Bradley E.

“…Glioblastoma (GBM) is thought to be driven by a subpopulation of cancer stem cells (CSCs) that self-renew and recapitulate tumor heterogeneity yet remain…”
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