Search Results - "Louis, DN"

Prolonged duration local anesthesia from tetrodotoxin-enhanced local anesthetic microspheres by Kohane, Daniel S, Smith, Sarah E, Louis, David N, Colombo, Gaia, Ghoroghchian, Peter, Hunfeld, Nicole G.M, Berde, Charles B, Langer, Robert

“…There is interest in developing prolonged duration local anesthesics. Here we examine whether tetrodotoxin (TTX) can be used to prolong the block from…”
Get full text

A Molecular Genetic Model of Astrocytoma Histopathology by Louis, David N.

“…As the molecular events responsible for astrocytoma formation and progression are being clarified, it is becoming possible to correlate these alterations with…”
Get full text

The treatment of oligodendrogliomas and mixed oligodendroglioma-astrocytomas with PCV chemotherapy by GLASS, J, HOCHBERG, F. H, GRUBER, M. L, LOUIS, D. N, SMITH, D, RATTNER, B

“…Malignant oligodendrogliomas have been shown to be responsive to chemotherapy. The authors administered systemic chemotherapy to seven patients with…”
Get full text

Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib by Lynch, Thomas J, Bell, Daphne W, Sordella, Raffaella, Gurubhagavatula, Sarada, Okimoto, Ross A, Brannigan, Brian W, Harris, Patricia L, Haserlat, Sara M, Supko, Jeffrey G, Haluska, Frank G, Louis, David N, Christiani, David C, Settleman, Jeff, Haber, Daniel A

“…Gefitinib, an inhibitor of the tyrosine kinase of the epidermal growth factor receptor (EGFR), is effective in less than 20 percent of patients with…”
Get full text

Oligodendroglioma: Toward Molecular Definitions in Diagnostic Neuro-Oncology by REIFENBERGER, GUIDO, LOUIS, DAVID N

“…Oligodendroglial tumors have attracted great interest in both basic and clinical neuro-oncology over the past decade. This interest is mainly due to the…”
Get full text

The WHO Classification of Tumors of the Nervous System by KLEIHUES, PAUL, LOUIS, DAVID N, SCHEITHAUER, BERND W, RORKE, LUCY B, REIFENBERGER, GUIDO, BURGER, PETER C, CAVENEE, WEBSTER K

“…The new World Health Organization (WHO) classification of nervous system tumors, published in 2000, emerged from a 1999 international consensus conference of…”
Get full text

Intragenic ERBB2 kinase mutations in tumours by Stephens, Philip, Hunter, Chris, Bignell, Graham, Edkins, Sarah, Davies, Helen, Teague, Jon, Stevens, Claire, O'Meara, Sarah, Smith, Raffaella, Parker, Adrian, Barthorpe, Andy, Blow, Matthew, Brackenbury, Lisa, Butler, Adam, Clarke, Oliver, Cole, Jennifer, Dicks, Ed, Dike, Angus, Drozd, Anja, Edwards, Ken, Forbes, Simon, Foster, Rebecca, Gray, Kristian, Greenman, Chris, Halliday, Kelly, Hills, Katy, Kosmidou, Vivienne, Lugg, Richard, Menzies, Andy, Perry, Janet, Petty, Robert, Raine, Keiran, Ratford, Lewis, Shepherd, Rebecca, Small, Alexandra, Stephens, Yvonne, Tofts, Calli, Varian, Jennifer, West, Sofie, Widaa, Sara, Yates, Andrew, Brasseur, Francis, Cooper, Colin S., Flanagan, Adrienne M., Knowles, Margaret, Leung, Suet Y., Louis, David N., Looijenga, Leendert H. J., Malkowicz, Bruce, Pierotti, Marco A., Teh, Bin, Chenevix-Trench, Georgia, Weber, Barbara L., Yuen, Siu T., Harris, Grace, Goldstraw, Peter, Nicholson, Andrew G., Futreal, P. Andrew, Wooster, Richard, Stratton, Michael R.

“…The protein-kinase family is the most frequently mutated gene family found in human cancer and faulty kinase enzymes are being investigated as promising…”
Get full text

Gene expression-based classification of malignant gliomas correlates better with survival than histological classification by NUTT, Catherine L, MANI, D. R, BLACK, Peter M, VON DEIMLING, Andreas, POMEROY, Scott L, GOLUB, Todd R, LOUIS, David N, BETENSKY, Rebecca A, TAMAYO, Pablo, CAIRNCROSS, J. Gregory, LADD, Christine, POHL, Ute, HARTMANN, Christian, MCLAUGHLIN, Margaret E, BATCHELOR, Tracy T

“…In modern clinical neuro-oncology, histopathological diagnosis affects therapeutic decisions and prognostic estimation more than any other variable. Among…”
Get full text

A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy by HUNTER, Chris, SMITH, Raffaella, O'MEARA, Sarah, PARKER, Adrian, AVIS, Tim, BARTHORPE, Syd, BRACKENBURY, Lisa, BUCK, Gemma, BUTLER, Adam, CLEMENTS, Jody, COLE, Jennifer, DICKS, Ed, CAHILL, Daniel P, FORBES, Simon, GORTON, Matthew, GRAY, Kristian, HALLIDAY, Kelly, HARRISON, Rachel, HILLS, Katy, HINTON, Jonathon, JENKINSON, Andy, JONES, David, KOSMIDOU, Vivienne, STEPHENS, Philip, LAMAN, Ross, LUGG, Richard, MENZIES, Andrew, PERRY, Janet, PETTY, Robert, RAINE, Keiran, RICHARDSON, David, SHEPHERD, Rebecca, SMALL, Alexandra, SOLOMON, Helen, STEVENS, Claire, TOFTS, Calli, VARIAN, Jennifer, WEST, Sofie, WIDAA, Sara, YATES, Andy, EASTON, Douglas F, RIGGINS, Gregory, ROY, Jennifer E, LEVINE, Kymberly K, MUELLER, Wolf, TEAGUE, Jon, BATCHELOR, Tracy T, LOUIS, David N, STRATTON, Michael R, FUTREAL, P. Andrew, WOOSTER, Richard, GREENMAN, Chris, EDKINS, Sarah, BIGNELL, Graham, DAVIES, Helen

“…Malignant gliomas have a very poor prognosis. The current standard of care for these cancers consists of extended adjuvant treatment with the alkylating agent…”
Get full text

The Oligodendroglial Lineage Marker OLIG2 Is Universally Expressed in Diffuse Gliomas by LIGON, KEITH L, ALBERTA, JOHN A, KHO, ALVIN T, WEISS, JENNIFER, KWAAN, MARY R, NUTT, CATHERINE L, LOUIS, DAVID N, STILES, CHARLES D, ROWITCH, DAVID H

“…Astrocytomas, oligodendrogliomas, and oligoastrocytomas, collectively referred to as diffuse gliomas, are the most common primary brain tumors. These tumors…”
Get full text

PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo by Dai, C, Celestino, J C, Okada, Y, Louis, D N, Fuller, G N, Holland, E C

“…We present evidence that some low-grade oligodendrogliomas may be comprised of proliferating glial progenitor cells that are blocked in their ability to…”
Get full text

Prediction of central nervous system embryonal tumour outcome based on gene expression by Pomeroy, Scott L, Golub, Todd R, Tamayo, Pablo, Gaasenbeek, Michelle, Sturla, Lisa M, Angelo, Michael, McLaughlin, Margaret E, Kim, John Y. H, Goumnerova, Liliana C, Black, Peter M, Lau, Ching, Allen, Jeffrey C, Zagzag, David, Olson, James M, Curran, Tom, Wetmore, Cynthia, Biegel, Jaclyn A, Poggio, Tomaso, Mukherjee, Shayan, Rifkin, Ryan, Califano, Andrea, Stolovitzky, Gustavo, Louis, David N, Mesirov, Jill P, Lander, Eric S

“…Embryonal tumours of the central nervous system (CNS) represent a heterogeneous group of tumours about which little is known biologically, and whose diagnosis,…”
Get full text

A phase I open-label, dose-escalation, multi-institutional trial of injection with an E1B-Attenuated adenovirus, ONYX-015, into the peritumoral region of recurrent malignant gliomas, in the adjuvant setting by Chiocca, E Antonio, Abbed, Khalid M, Tatter, Stephen, Louis, David N, Hochberg, Fred H, Barker, Fred, Kracher, Jean, Grossman, Stuart A, Fisher, Joy D, Carson, Kathryn, Rosenblum, Mark, Mikkelsen, Tom, Olson, Jeff, Markert, James, Rosenfeld, Steven, Nabors, L Burt, Brem, Steven, Phuphanich, Surasak, Freeman, Scott, Kaplan, Rick, Zwiebel, James

“…ONYX-015 is an oncolytic virus untested as a treatment for malignant glioma. The NABTT CNS Consortium conducted a dose-escalation trial of intracerebral…”
Get full text

Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics by Dickson, M A, Hahn, W C, Ino, Y, Ronfard, V, Wu, J Y, Weinberg, R A, Louis, D N, Li, F P, Rheinwald, J G

“…Normal human cells exhibit a limited replicative life span in culture, eventually arresting growth by a process termed senescence. Progressive telomere…”
Get full text

Epidermal growth factor receptor and Ink4a/Arf: Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis by Bachoo, Robert M, Maher, Elizabeth A, Ligon, Keith L, Sharpless, Norman E, Chan, Suzanne S, You, Mingjian James, Tang, Yi, DeFrances, Jessica, Stover, Elizabeth, Weissleder, Ralph, Rowitch, David H, Louis, David N, DePinho, Ronald A

“…Ink4a/Arf inactivation and epidermal growth factor receptor (EGFR) activation are signature lesions in high-grade gliomas. How these mutations mediate the…”
Get full text

Glioma classification : A molecular reappraisal by LOUIS, David N, HOLLAND, Eric C, CAIRNCROSS, J. Gregory

Get full text

Localized crystal‐storing histiocytosis of the posterior fossa by Flanagan, Margaret E., Keene, Christopher Dirk, Louis, David N., Juric‐Sekhar, Gordana

“…Crystal‐storing histiocytosis (CSH) is an uncommon histiocytic proliferation reported to involve diverse organs and tissues, but involvement of the central…”
Get full text

Molecular subtypes of anaplastic oligodendroglioma : Implications for patient management at diagnosis by INO, Yasushi, BETENSKY, Rebecca A, ZLATESCU, Magdalena C, SASAKI, Hikaru, MACDONALD, David R, STEMMER-RACHAMIMOV, Anat O, RAMSAY, David A, CAIRNCROSS, J. Gregory, LOUIS, David N

“…In a prior study of anaplastic oligodendrogliomas treated with chemotherapy at diagnosis or at recurrence after radiotherapy, allelic loss of chromosome 1p…”
Get full text

Genetic Alterations of Phosphoinositide 3-kinase Subunit Genes in Human Glioblastomas by Mizoguchi, Masahiro, Nutt, Catherine L., Mohapatra, Gayatry, Louis, David N.

“…Genetic alterations of PI3K (phosphoinositide 3‐kinase) subunits have been documented in a number of tumor types, with increased PI3K activity linked to gene…”
Get full text

Specific Genetic Predictors of Chemotherapeutic Response and Survival in Patients With Anaplastic Oligodendrogliomas by Cairncross, J. Gregory, Ueki, Keisuke, Zlatescu, Magdelena C., Lisle, David K., Finkelstein, Dianne M., Hammond, Robert R., Silver, Jonathan S., Stark, Paul C., Macdonald, David R., Ino, Yasushi, Ramsay, David A., Louis, David N.

“…Background/Methods: Gliomas are common malignant neoplasms of the central nervous system. Among the major subtypes of gliomas, oligodendrogliomas are…”
Get full text