Search Results - "Louie, Steven W."

From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) by Cheng, Yuan, Judd, Ted C, Bartberger, Michael D, Brown, James, Chen, Kui, Fremeau, Robert T, Hickman, Dean, Hitchcock, Stephen A, Jordan, Brad, Li, Vivian, Lopez, Patricia, Louie, Steven W, Luo, Yi, Michelsen, Klaus, Nixey, Thomas, Powers, Timothy S, Rattan, Claire, Sickmier, E. Allen, St. Jean, David J, Wahl, Robert C, Wen, Paul H, Wood, Stephen

“…Using fragment-based screening of a focused fragment library, 2-aminoquinoline 1 was identified as an initial hit for BACE1. Further SAR development was…”
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Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux by Rzasa, Robert M., Hu, Essa, Rumfelt, Shannon, Chen, Ning, Andrews, Kristin L., Chmait, Samer, Falsey, James R., Zhong, Wenge, Jones, Adrie D., Porter, Amy, Louie, Steven W., Zhao, Xiaoning, Treanor, James J.S., Allen, Jennifer R.

“…We report the discovery of a novel series of biaryl ethers as potent and selective PDE10A inhibitors. Structure–activity studies improved the potency and…”
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Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide) by Subramanian, Raju, Zhu, Xiaochun, Kerr, Savannah J, Esmay, Joel D, Louie, Steven W, Edson, Katheryne Z, Walter, Sarah, Fitzsimmons, Michael, Wagner, Mylo, Soto, Marcus, Pham, Roger, Wilson, Sarah F, Skiles, Gary L

“…AMG 416 (etelcalcetide) is a novel synthetic peptide agonist of the calcium-sensing receptor composed of a linear chain of seven d-amino acids (referred to as…”
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Disubstituted 1‑Aryl-4-Aminopiperidine Library Synthesis Using Computational Drug Design and High-Throughput Batch and Flow Technologies by Bryan, Marian C, Hein, Christopher D, Gao, Hua, Xia, Xiaoyang, Eastwood, Heather, Bruenner, Bernd A, Louie, Steven W, Doherty, Elizabeth M

“…A platform that incorporates computational library design, parallel solution-phase synthesis, continuous flow hydrogenation, and automated high throughput…”
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Development and characterization of LLC-PK1 cells containing Sprague–Dawley rat Abcb1a ( Mdr1a): Comparison of rat P-glycoprotein transport to human and mouse by Booth-Genthe, Catherine L., Louie, Steven W., Carlini, Edward J., Li, Bing, Leake, Brenda F., Eisenhandler, Roy, Hochman, Jerome H., Mei, Qin, Kim, Richard B., Rushmore, Thomas H., Yamazaki, Masayo

“…P-glycoprotein is localized in numerous tissues throughout the body and plays an important role in the disposition of many xenobiotics. The contribution of…”
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Positive and negative regulation of Thy-1 expression on B lymphocytes by IL-4 by Louie, S W, Ramirez, L M, Harton, J A, Bishop, G A

“…Expression of the Thy-1 membrane antigen is generally confined to thymocytes and T lymphocytes, but its expression on B lymphocytes can be induced by culture…”
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