Search Results - "Loughran, Stephen J"

Lineage commitment of hematopoietic stem cells and progenitors: insights from recent single cell and lineage tracing technologies by Loughran, Stephen J., Haas, Simon, Wilkinson, Adam C., Klein, Allon M., Brand, Marjorie

“…•Cellular lineage commitment within hematopoiesis is reviewed.•Insights from novel lineage tracing and single-cell transcriptomics studies are discussed.•How…”
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The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells by Kile, Benjamin T, Loughran, Stephen J, Kruse, Elizabeth A, Hacking, Douglas F, de Graaf, Carolyn A, Hyland, Craig D, Willson, Tracy A, Henley, Katya J, Ellis, Sarah, Voss, Anne K, Metcalf, Donald, Hilton, Douglas J, Alexander, Warren S

“…Ets family transcription factors function in mammalian development. Kile and colleagues demonstrate that the Ets family member Erg is essential for definitive…”
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Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome by Ng, Ashley P., Hyland, Craig D., Metcalf, Donald, Carmichael, Catherine L., Loughran, Stephen J., Di Rago, Ladina, Kile, Benjamin T., Alexander, Warren S.

“…Down syndrome is characterized by multiple phenotypic manifestations associated with trisomy of chromosome 21. The transient myeloproliferative disorder and…”
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Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage by Kruse, Elizabeth A, Loughran, Stephen J, Baldwin, Tracey M, Josefsson, Emma C, Ellis, Sarah, Watson, Dennis K, Nurden, Paquita, Metcalf, Donald, Hilton, Douglas J, Alexander, Warren S, Kile, Benjamin T

“…Fli-1 and Erg are closely related members of the Ets family of transcription factors. Both genes are translocated in human cancers, including Ewing's sarcoma,…”
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Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice by Ng, Ashley P., Loughran, Stephen J., Metcalf, Donald, Hyland, Craig D., de Graaf, Carolyn A., Hu, Yifang, Smyth, Gordon K., Hilton, Douglas J., Kile, Benjamin T., Alexander, Warren S.

“…Hematopoietic stem cells (HSCs) are rare residents of the bone marrow responsible for the lifelong production of blood cells. Regulation of the balance between…”
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New insight into the causes, consequences, and correction of hematopoietic stem cell aging by Mansell, Els, Lin, Dawn S., Loughran, Stephen J., Milsom, Michael D., Trowbridge, Jennifer J.

“…•Low-grade inflammation in early to mid-life accelerates mouse hematopoietic aging•The decline of niche factor insulin-like growth factor 1 drives the onset of…”
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Translational research for bone marrow failure patients by Malouf, Camille, Loughran, Stephen J., Wilkinson, Adam C., Shimamura, Akiko, Río, Paula

“…•Recent developments in bone marrow failure research are explored.•Distinct mechanisms of clonal evolution and implications for surveillance for patients…”
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Hematopoietic Stem Cell Heterogeneity Is Linked to the Initiation and Therapeutic Response of Myeloproliferative Neoplasms by Tong, Jingyuan, Sun, Ting, Ma, Shihui, Zhao, Yanhong, Ju, Mankai, Gao, Yuchen, Zhu, Ping, Tan, Puwen, Fu, Rongfeng, Zhang, Anqi, Wang, Ding, Wang, Di, Xiao, Zhijian, Zhou, Jiaxi, Yang, Renchi, Loughran, Stephen J., Li, Juan, Green, Anthony R., Bresnick, Emery H., Wang, Dong, Cheng, Tao, Zhang, Lei, Shi, Lihong

“…The implications of stem cell heterogeneity for disease pathogenesis and therapy are poorly defined. JAK2V617F+ myeloproliferative neoplasms (MPNs), harboring…”
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Iron homeostasis governs erythroid phenotype in polycythemia vera by Bennett, Cavan, Jackson, Victoria E., Pettikiriarachchi, Anne, Hayman, Thomas, Schaeper, Ute, Moir-Meyer, Gemma, Fielding, Katherine, Ataide, Ricardo, Clucas, Danielle, Baldi, Andrew, Garnham, Alexandra L., Li-Wai-Suen, Connie S. N., Loughran, Stephen J., Baxter, E. Joanna, Green, Anthony R., Alexander, Warren S., Bahlo, Melanie, Burbury, Kate, Ng, Ashley P., Pasricha, Sant-Rayn

“…•Homozygous HFE mutations are overrepresented in patients with PV.•Hepcidin levels govern severity of, and can be manipulated to modify, the erythroid…”
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Hematopoietic stem cell heterogeneity is linked to the initiation and therapeutic response of myeloproliferative neoplasms by Tong, Jingyuan, Sun, Ting, Ma, Shihui, Zhao, Yanhong, Ju, Mankai, Gao, Yuchen, Zhu, Ping, Tan, Puwen, Fu, Rongfeng, Zhang, Anqi, Wang, Ding, Wang, Di, Xiao, Zhijian, Zhou, Jiaxi, Yang, Renchi, Loughran, Stephen J., Li, Juan, Green, Anthony R., Bresnick, Emery H., Wang, Dong, Cheng, Tao, Zhang, Lei, Shi, Lihong

“…The implications of stem cell heterogeneity for disease pathogenesis and therapy are poorly defined. JAK2V617F + myeloproliferative neoplasms (MPNs), harboring…”
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Murine hematopoietic blast colony-forming cells and their progeny have distinctive membrane marker profiles by Metcalf, Donald, Ng, Ashley P, Loughran, Stephen J.L, Phipson, Belinda, Smyth, Gordon K, Di Rago, Ladina, Mifsud, Sandra

“…Two distinct bone marrow-derived blast colony-forming cells can generate colonies of lineage-restricted progenitor cells in agar cultures of murine bone…”
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The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential by Luc, Sidinh, Luis, Tiago C, Boukarabila, Hanane, Macaulay, Iain C, Buza-Vidas, Natalija, Bouriez-Jones, Tiphaine, Lutteropp, Michael, Woll, Petter S, Loughran, Stephen J, Mead, Adam J, Hultquist, Anne, Brown, John, Mizukami, Takuo, Matsuoka, Sahoko, Ferry, Helen, Anderson, Kristina, Duarte, Sara, Atkinson, Deborah, Soneji, Shamit, Domanski, Aniela, Farley, Alison, Sanjuan-Pla, Alejandra, Carella, Cintia, Patient, Roger, de Bruijn, Marella, Enver, Tariq, Nerlov, Claus, Blackburn, Clare, Godin, Isabelle, Jacobsen, Sten Eirik W

“…The commitment stage at which progenitors seed the thymus remains unclear. Jacobsen and colleagues show that the earliest progenitors in the neonatal thymus…”
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Mbd3/NuRD controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program by Loughran, Stephen J, Comoglio, Federico, Hamey, Fiona K, Giustacchini, Alice, Errami, Youssef, Earp, Eleanor, Göttgens, Berthold, Jacobsen, Sten Eirik W, Mead, Adam J, Hendrich, Brian, Green, Anthony R

“…Differentiation of lineage-committed cells from multipotent progenitors requires the establishment of accessible chromatin at lineage-specific transcriptional…”
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Mechanisms of lymphangiogenesis: targets for blocking the metastatic spread of cancer by McColl, Bradley K, Loughran, Stephen J, Davydova, Natalia, Stacker, Steven A, Achen, Marc G

“…The lymphatic vasculature is an important route of metastatic spread in cancer and recent studies have demonstrated that lymphangiogenesis (the growth of…”
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The Genomic Landscape of Myeloproliferative Neoplasms: Somatic Calr Mutations in the Majority of JAK2-Wildtype Patients by Nangalia, Jyoti, Massie, Charles, Baxter, E Joanna, Nice, Francesca L, Gundem, Gunes, Wedge, David, Avezov, Edward, Li, Juan, Kollmann, Karoline, Kent, David G., Aziz, Athar, Godfrey, Anna L, Hinton, Jonathan, Martincorena, Inigo, Van Loo, Peter, Jones, Amy V, Guglielmelli, Paola, Tarpey, Patrick, Harding, Heather P, Fitzpatrick, John D, Goudie, Calum T, Ortmann, Christina A, Loughran, Stephen J, Raine, Keiran, Jones, David, Butler, Adam, Teague, Jon W, O'Meara, Sarah, McLaren, Stuart, Bianchi, Michele, Silber, Yvonne, Dimitropolou, Danai, Bloxham, David, Mudie, Laura J, Maddison, Mark, Robinson, Ben, Keohane, Clodagh, MacLean, Cathy, Hill, Kate, Orchard, Kim H., Tauro, Sudhir, Du, Ming-Qing, Greaves, Mel, Bowen, David, Huntly, Brian, Harrison, Claire N, Cross, Nicholas C.P., Ron, David, Vannucchi, Alessandro M, Papaemmanuil, Elli, Campbell, Peter J., Green, Anthony R

“…BCR-ABL negative myeloproliferative neoplasms (MPNs), such as polycythemia vera (PV), essential thrombocythemia (ET) and myelofibrosis (MF) are chronic myeloid…”
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The Earliest Thymic T Cell Progenitors Sustain B Cell and Myeloid Lineage Potentials by Luc, Sidinh, Luis, Tiago C., Boukarabila, Hanane, Macaulay, Iain C., Buza-Vidas, Natalija, Bouriez-Jones, Tiphaine, Lutteropp, Michael, Woll, Petter S., Loughran, Stephen J., Mead, Adam J., Hultquist, Anne, Brown, John, Mizukami, Takuo, Matsuoka, Sahoko, Ferry, Helen, Anderson, Kristina, Duarte, Sara, Atkinson, Deborah, Soneji, Shamit, Domanski, Aniela, Farley, Alison, Sanjuan-Pla, Alejandra, Carella, Cintia, Patient, Roger, de Bruijn, Marella, Enver, Tariq, Nerlov, Claus, Blackburn, Clare, Godin, Isabelle, Jacobsen, Sten Eirik W.

“…The stepwise commitment from hematopoietic stem cells in the bone marrow (BM) to T lymphocyte-restricted progenitors in the thymus represents a paradigm for…”
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