Search Results - "Loughran, Stephen"

Lineage commitment of hematopoietic stem cells and progenitors: insights from recent single cell and lineage tracing technologies by Loughran, Stephen J., Haas, Simon, Wilkinson, Adam C., Klein, Allon M., Brand, Marjorie

“…•Cellular lineage commitment within hematopoiesis is reviewed.•Insights from novel lineage tracing and single-cell transcriptomics studies are discussed.•How…”
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Development and characterization of self-assembling nanoparticles using a bio-inspired amphipathic peptide for gene delivery by McCarthy, Helen O, McCaffrey, Joanne, McCrudden, Cian M, Zholobenko, Aleksey, Ali, Ahlam A, McBride, John W, Massey, Ashley S, Pentlavalli, Sreekanth, Chen, Kun-Hung, Cole, Grace, Loughran, Stephen P, Dunne, Nicholas J, Donnelly, Ryan F, Kett, Victoria L, Robson, Tracy

“…The design of a non-viral gene delivery vehicle capable of delivering and releasing a functional nucleic acid cargo intracellularly remains a formidable…”
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New insight into the causes, consequences, and correction of hematopoietic stem cell aging by Mansell, Els, Lin, Dawn S., Loughran, Stephen J., Milsom, Michael D., Trowbridge, Jennifer J.

“…•Low-grade inflammation in early to mid-life accelerates mouse hematopoietic aging•The decline of niche factor insulin-like growth factor 1 drives the onset of…”
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Iron homeostasis governs erythroid phenotype in polycythemia vera by Bennett, Cavan, Jackson, Victoria E., Pettikiriarachchi, Anne, Hayman, Thomas, Schaeper, Ute, Moir-Meyer, Gemma, Fielding, Katherine, Ataide, Ricardo, Clucas, Danielle, Baldi, Andrew, Garnham, Alexandra L., Li-Wai-Suen, Connie S. N., Loughran, Stephen J., Baxter, E. Joanna, Green, Anthony R., Alexander, Warren S., Bahlo, Melanie, Burbury, Kate, Ng, Ashley P., Pasricha, Sant-Rayn

“…•Homozygous HFE mutations are overrepresented in patients with PV.•Hepcidin levels govern severity of, and can be manipulated to modify, the erythroid…”
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Rational design and characterisation of a linear cell penetrating peptide for non-viral gene delivery by McErlean, Emma M., Ziminska, Monika, McCrudden, Cian M., McBride, John W., Loughran, Stephen P., Cole, Grace, Mulholland, Eoghan J., Kett, Vicky, Buckley, Niamh E., Robson, Tracy, Dunne, Nicholas J., McCarthy, Helen O.

“…The design of a non-viral gene delivery system that can release a functional nucleic acid at the intracellular destination site is an exciting but also…”
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Translational research for bone marrow failure patients by Malouf, Camille, Loughran, Stephen J., Wilkinson, Adam C., Shimamura, Akiko, Río, Paula

“…•Recent developments in bone marrow failure research are explored.•Distinct mechanisms of clonal evolution and implications for surveillance for patients…”
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Hematopoietic Stem Cell Heterogeneity Is Linked to the Initiation and Therapeutic Response of Myeloproliferative Neoplasms by Tong, Jingyuan, Sun, Ting, Ma, Shihui, Zhao, Yanhong, Ju, Mankai, Gao, Yuchen, Zhu, Ping, Tan, Puwen, Fu, Rongfeng, Zhang, Anqi, Wang, Ding, Wang, Di, Xiao, Zhijian, Zhou, Jiaxi, Yang, Renchi, Loughran, Stephen J., Li, Juan, Green, Anthony R., Bresnick, Emery H., Wang, Dong, Cheng, Tao, Zhang, Lei, Shi, Lihong

“…The implications of stem cell heterogeneity for disease pathogenesis and therapy are poorly defined. JAK2V617F+ myeloproliferative neoplasms (MPNs), harboring…”
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The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells by Kile, Benjamin T, Loughran, Stephen J, Kruse, Elizabeth A, Hacking, Douglas F, de Graaf, Carolyn A, Hyland, Craig D, Willson, Tracy A, Henley, Katya J, Ellis, Sarah, Voss, Anne K, Metcalf, Donald, Hilton, Douglas J, Alexander, Warren S

“…Ets family transcription factors function in mammalian development. Kile and colleagues demonstrate that the Ets family member Erg is essential for definitive…”
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Hematopoietic stem cell heterogeneity is linked to the initiation and therapeutic response of myeloproliferative neoplasms by Tong, Jingyuan, Sun, Ting, Ma, Shihui, Zhao, Yanhong, Ju, Mankai, Gao, Yuchen, Zhu, Ping, Tan, Puwen, Fu, Rongfeng, Zhang, Anqi, Wang, Ding, Wang, Di, Xiao, Zhijian, Zhou, Jiaxi, Yang, Renchi, Loughran, Stephen J., Li, Juan, Green, Anthony R., Bresnick, Emery H., Wang, Dong, Cheng, Tao, Zhang, Lei, Shi, Lihong

“…The implications of stem cell heterogeneity for disease pathogenesis and therapy are poorly defined. JAK2V617F + myeloproliferative neoplasms (MPNs), harboring…”
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The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential by Luc, Sidinh, Luis, Tiago C, Boukarabila, Hanane, Macaulay, Iain C, Buza-Vidas, Natalija, Bouriez-Jones, Tiphaine, Lutteropp, Michael, Woll, Petter S, Loughran, Stephen J, Mead, Adam J, Hultquist, Anne, Brown, John, Mizukami, Takuo, Matsuoka, Sahoko, Ferry, Helen, Anderson, Kristina, Duarte, Sara, Atkinson, Deborah, Soneji, Shamit, Domanski, Aniela, Farley, Alison, Sanjuan-Pla, Alejandra, Carella, Cintia, Patient, Roger, de Bruijn, Marella, Enver, Tariq, Nerlov, Claus, Blackburn, Clare, Godin, Isabelle, Jacobsen, Sten Eirik W

“…The commitment stage at which progenitors seed the thymus remains unclear. Jacobsen and colleagues show that the earliest progenitors in the neonatal thymus…”
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Mbd3/NuRD controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program by Loughran, Stephen J, Comoglio, Federico, Hamey, Fiona K, Giustacchini, Alice, Errami, Youssef, Earp, Eleanor, Göttgens, Berthold, Jacobsen, Sten Eirik W, Mead, Adam J, Hendrich, Brian, Green, Anthony R

“…Differentiation of lineage-committed cells from multipotent progenitors requires the establishment of accessible chromatin at lineage-specific transcriptional…”
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Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome by Ng, Ashley P., Hyland, Craig D., Metcalf, Donald, Carmichael, Catherine L., Loughran, Stephen J., Di Rago, Ladina, Kile, Benjamin T., Alexander, Warren S.

“…Down syndrome is characterized by multiple phenotypic manifestations associated with trisomy of chromosome 21. The transient myeloproliferative disorder and…”
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Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage by Kruse, Elizabeth A, Loughran, Stephen J, Baldwin, Tracey M, Josefsson, Emma C, Ellis, Sarah, Watson, Dennis K, Nurden, Paquita, Metcalf, Donald, Hilton, Douglas J, Alexander, Warren S, Kile, Benjamin T

“…Fli-1 and Erg are closely related members of the Ets family of transcription factors. Both genes are translocated in human cancers, including Ewing's sarcoma,…”
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Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice by Ng, Ashley P., Loughran, Stephen J., Metcalf, Donald, Hyland, Craig D., de Graaf, Carolyn A., Hu, Yifang, Smyth, Gordon K., Hilton, Douglas J., Kile, Benjamin T., Alexander, Warren S.

“…Hematopoietic stem cells (HSCs) are rare residents of the bone marrow responsible for the lifelong production of blood cells. Regulation of the balance between…”
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Mutant calreticulin knockin mice develop thrombocytosis and myelofibrosis without a stem cell self-renewal advantage by Li, Juan, Prins, Daniel, Park, Hyun Jung, Grinfeld, Jacob, Gonzalez-Arias, Carlos, Loughran, Stephen, Dovey, Oliver M., Klampfl, Thorsten, Bennett, Cavan, Hamilton, Tina L., Pask, Dean C., Sneade, Rachel, Williams, Matthew, Aungier, Juliet, Ghevaert, Cedric, Vassiliou, George S., Kent, David G., Green, Anthony R.

“…Somatic mutations in the endoplasmic reticulum chaperone calreticulin (CALR) are detected in approximately 40% of patients with essential thrombocythemia (ET)…”
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Murine hematopoietic blast colony-forming cells and their progeny have distinctive membrane marker profiles by Metcalf, Donald, Ng, Ashley P, Loughran, Stephen J.L, Phipson, Belinda, Smyth, Gordon K, Di Rago, Ladina, Mifsud, Sandra

“…Two distinct bone marrow-derived blast colony-forming cells can generate colonies of lineage-restricted progenitor cells in agar cultures of murine bone…”
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FLT3-ITDs Instruct a Myeloid Differentiation and Transformation Bias in Lymphomyeloid Multipotent Progenitors by Mead, Adam J., Kharazi, Shabnam, Atkinson, Deborah, Macaulay, Iain, Pecquet, Christian, Loughran, Stephen, Lutteropp, Michael, Woll, Petter, Chowdhury, Onima, Luc, Sidinh, Buza-Vidas, Natalija, Ferry, Helen, Clark, Sally-Ann, Goardon, Nicolas, Vyas, Paresh, Constantinescu, Stefan N., Sitnicka, Ewa, Nerlov, Claus, Jacobsen, Sten Eirik W.

“…Whether signals mediated via growth factor receptors (GFRs) might influence lineage fate in multipotent progenitors (MPPs) is unclear. We explored this issue…”
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Mechanisms of lymphangiogenesis: targets for blocking the metastatic spread of cancer by McColl, Bradley K, Loughran, Stephen J, Davydova, Natalia, Stacker, Steven A, Achen, Marc G

“…The lymphatic vasculature is an important route of metastatic spread in cancer and recent studies have demonstrated that lymphangiogenesis (the growth of…”
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3006 – JAK2 PHOSPHORYLATES THE RNA PROCESSING PROTEIN HNRNPA1 TO REPRESS THE EXPRESSION OF RETROTRANSPOSONS AND PROTECT THE HAEMATOPOIETIC STEM CELL GENOME by Loughran, Stephen, Deuel, Jeremy, Green, Tony, Oellerich, Thomas

“…The JAK2 kinase phosphorylates tyrosines on key signalling proteins upon the activation of cytokine receptors, and is therefore an essential component of the…”
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Peripherally Inserted Central Catheters: A Report of 2506 Catheter Days by Loughran, Stephen C., Borzatta, Marcello

“…Background: The establishment of reliable central venous access is essential in the management of patients with major complications, including pneumothorax and…”
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