Search Results - "Loughlin, Fionna E"

Tandem RNA binding sites induce self-association of the stress granule marker protein TIA-1 by Loughlin, Fionna E, West, Danella L, Gunzburg, Menachem J, Waris, Saboora, Crawford, Simon A, Wilce, Matthew C J, Wilce, Jacqueline A

“…Abstract TIA-1 is an RNA-binding protein that sequesters target RNA into stress granules under conditions of cellular stress. Promotion of stress granule…”
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Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis by Jutzi, Daniel, Campagne, Sébastien, Schmidt, Ralf, Reber, Stefan, Mechtersheimer, Jonas, Gypas, Foivos, Schweingruber, Christoph, Colombo, Martino, von Schroetter, Christine, Loughlin, Fionna E., Devoy, Anny, Hedlund, Eva, Zavolan, Mihaela, Allain, Frédéric H.-T., Ruepp, Marc-David

“…Mutations in the RNA-binding protein Fused in Sarcoma (FUS) cause early-onset amyotrophic lateral sclerosis (ALS). However, a detailed understanding of central…”
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Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28 by Loughlin, Fionna E, Gebert, Luca F R, Towbin, Harry, Brunschweiger, Andreas, Hall, Jonathan, Allain, Frédéric H-T

“…Lin28 prevents the processing of pre-let-7 RNAs, but it is not clear where the Lin28 RNA binding domains interact with the RNA. The NMR structure of the Lin28…”
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The solution structure of Dead End bound to AU-rich RNA reveals an unusual mode of tandem RRM-RNA recognition required for mRNA regulation by Duszczyk, Malgorzata M., Wischnewski, Harry, Kazeeva, Tamara, Arora, Rajika, Loughlin, Fionna E., von Schroetter, Christine, Pradère, Ugo, Hall, Jonathan, Ciaudo, Constance, Allain, Frédéric H.-T.

“…Dead End (DND1) is an RNA-binding protein essential for germline development through its role in post-transcriptional gene regulation. The molecular mechanisms…”
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Regulation of TIA-1 Condensates: Zn2+ and RGG Motifs Promote Nucleic Acid Driven LLPS and Inhibit Irreversible Aggregation by West, Danella L., Loughlin, Fionna E., Rivero-Rodríguez, Francisco, Vankadari, Naveen, Velázquez-Cruz, Alejandro, Corrales-Guerrero, Laura, Díaz-Moreno, Irene, Wilce, Jacqueline A.

“…Stress granules are non-membrane bound RNA-protein granules essential for survival during acute cellular stress. TIA-1 is a key protein in the formation of…”
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Crystal Structures of Flax Rust Avirulence Proteins AvrL567-A and -D Reveal Details of the Structural Basis for Flax Disease Resistance Specificity by Wang, Ching -I.A, Gunčar, Gregor, Forwood, Jade K, Teh, Trazel, Catanzariti, Ann-Maree, Lawrence, Gregory J, Loughlin, Fionna E, Mackay, Joel P, Schirra, Horst Joachim, Anderson, Peter A, Ellis, Jeffrey G, Dodds, Peter N, Kobe, Boštjan

“…The gene-for-gene mechanism of plant disease resistance involves direct or indirect recognition of pathogen avirulence (Avr) proteins by plant resistance (R)…”
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zinc fingers of the SR-like protein ZRANB2 are single-stranded RNA-binding domains that recognize 5' splice site-like sequences by Loughlin, Fionna E, Mansfield, Robyn E, Vaz, Paula M, McGrath, Aaron P, Setiyaputra, Surya, Gamsjaeger, Roland, Chen, Eva S, Morris, Brian J, Guss, J. Mitchell, Mackay, Joel P

“…The alternative splicing of mRNA is a critical process in higher eukaryotes that generates substantial proteomic diversity. Many of the proteins that are…”
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TDP-43 and FUS–structural insights into RNA recognition and self-association by Loughlin, Fionna E, Wilce, Jacqueline A

“…•Common and unique features influence RNA interaction and self-association by TDP-43 and FUS.•TDP-43 binds RNA sequence specifically whereas FUS binds both…”
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The Solution Structure of FUS Bound to RNA Reveals a Bipartite Mode of RNA Recognition with Both Sequence and Shape Specificity by Loughlin, Fionna E., Lukavsky, Peter J., Kazeeva, Tamara, Reber, Stefan, Hock, Eva-Maria, Colombo, Martino, Von Schroetter, Christine, Pauli, Phillip, Cléry, Antoine, Mühlemann, Oliver, Polymenidou, Magdalini, Ruepp, Marc-David, Allain, Frédéric H.-T.

“…Fused in sarcoma (FUS) is an RNA binding protein involved in regulating many aspects of RNA processing and linked to several neurodegenerative diseases…”
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Zinc Fingers as Protein Recognition Motifs: Structural Basis for the GATA-1/Friend of GATA Interaction by Liew, Chu Kong, Raina J. Y. Simpson, Ann H. Y. Kwan, Crofts, Linda A., Loughlin, Fionna E., Matthews, Jacqueline M., Crossley, Merlin, Mackay, Joel P., Orkin, Stuart H.

“…GATA-1 and friend of GATA (FOG) are zinc-finger transcription factors that physically interact to play essential roles in erythroid and megakaryocytic…”
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Sticky fingers: zinc-fingers as protein-recognition motifs by Gamsjaeger, Roland, Liew, Chu Kong, Loughlin, Fionna E., Crossley, Merlin, Mackay, Joel P.

“…Zinc-fingers (ZnFs) are extremely abundant in higher eukaryotes. Once considered to function exclusively as sequence-specific DNA-binding motifs, ZnFs are now…”
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Analysis of the Structure and Function of the Transcriptional Coregulator HOP by Kook, Hyun, Yung, Wendy W, Simpson, Raina J, Kee, Hae Jin, Shin, Sera, Lowry, Jason A, Loughlin, Fionna E, Yin, Zhan, Epstein, Jonathan A, Mackay, Joel P

“…Homeodomain-only protein (HOP) is an 8-kDa transcriptional corepressor that is essential for the normal development of the mammalian heart. Previous studies…”
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Characterization of a Family of RanBP2-Type Zinc Fingers that Can Recognize Single-Stranded RNA by Nguyen, Cuong D., Mansfield, Robyn E., Leung, Wilfred, Vaz, Paula M., Loughlin, Fionna E., Grant, Richard P., Mackay, Joel P.

“…The recognition of single-stranded RNA (ssRNA) is an important aspect of gene regulation, and a number of different classes of protein domains that recognize…”
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The NMR signature of gluconoylation: a frequent N-terminal modification of isotope-labeled proteins by Schweida, David, Barraud, Pierre, Regl, Christof, Loughlin, Fionna E., Huber, Christian G., Cabrele, Chiara, Schubert, Mario

“…N-terminal gluconoylation is a moderately widespread modification in recombinant proteins expressed in Escherichia coli , in particular in proteins bearing an…”
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TIA-1 RRM23 binding and recognition of target oligonucleotides by Waris, Saboora, García-Mauriño, Sofía M, Sivakumaran, Andrew, Beckham, Simone A, Loughlin, Fionna E, Gorospe, Myriam, Díaz-Moreno, Irene, Wilce, Matthew C J, Wilce, Jacqueline A

“…TIA-1 (T-cell restricted intracellular antigen-1) is an RNA-binding protein involved in splicing and translational repression. It mainly interacts with RNA via…”
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Designed metal-binding sites in biomolecular and bioinorganic interactions by Matthews, Jacqueline M, Loughlin, Fionna E, Mackay, Joel P

“…The design of metal-binding functionality in proteins is expanding into many different areas with a wide range of practical and research applications. Here we…”
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Zinc fingers are known as domains for binding DNA and RNA. Do they also mediate protein‐protein interactions? by Loughlin, Fionna E., Mackay, Joel P.

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Crystallization of a ZRANB2-RNA complex by Loughlin, Fionna E., Lee, Mihwa, Guss, J. Mitchell, Mackay, Joel P.

“…ZRANB2 is a zinc‐finger protein that has been shown to influence alternative splice‐site selection. The protein comprises a C‐terminal arginine/serine‐rich…”
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Crystallization of a ZRANB2aRNA complex by Loughlin, Fionna E, Lee, Mihwa, Guss, J Mitchell, Mackay, Joel P

“…ZRANB2 is a zinc-finger protein that has been shown to influence alternative splice-site selection. The protein comprises a C-terminal arginine/serine-rich…”
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