Search Results - "Lougheed, Marilee"

Role of oxidatively modified LDL in atherosclerosis by Steinbrecher, U P, Zhang, H F, Lougheed, M

“…Oxidative modification of LDL is accompanied by a number of compositional and structural changes, including increased electrophoretic mobility, increased…”
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Mechanism of Uptake of Copper-oxidized Low Density Lipoprotein in Macrophages Is Dependent on Its Extent of Oxidation (∗) by Lougheed, Marilee, Steinbrecher, Urs P.

“…Several investigators have reported nonreciprocal cross-competition between unlabeled acetyl low density lipoprotein (LDL) and oxidized LDL for the degradation…”
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High Affinity Saturable Uptake of Oxidized Low Density Lipoprotein by Macrophages from Mice Lacking the Scavenger Receptor Class A Type I/II by Lougheed, Marilee, Lum, Corey Ming, Ling, Wenhua, Suzuki, Hiroshi, Kodama, Tatsuhiko, Steinbrecher, Urs

“…Oxidation of low density lipoproteins (LDL) has been implicated as a causal factor in the pathogenesis of atherosclerosis. Oxidized LDL has been found to…”
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Phosphorothioate oligodeoxynucleotides distribute similarly in class A scavenger receptor knockout and wild-type mice by Butler, M, Crooke, R M, Graham, M J, Lemonidis, K M, Lougheed, M, Murray, S F, Witchell, D, Steinbrecher, U, Bennett, C F

“…It has been suggested that binding of phosphorothioate oligodeoxynucleotides (P=S ODNs) to macrophage scavenger receptors (SR-AI/II) is the primary mechanism…”
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A modification of apolipoprotein B accounts for most of the induction of macrophage growth by oxidized low density lipoprotein by Martens, J.S. (University of British Columbia, Vancouver, British Columbia, Canada.), Lougheed, M, Gomez-Munoz, A, Steinbrecher, U.P

“…It has recently been shown that macrophage proliferation occurs during the progression of atherosclerotic lesions and that oxidized low density lipoprotein…”
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Fluorescent adducts formed by reaction of oxidized unsaturated fatty acids with amines increase macrophage viability by Riazy, Maziar, Lougheed, Marilee, Adomat, Hans H., Guns, Emma S. Tomlinson, Eigendorf, Guenter K., Duronio, Vincent, Steinbrecher, Urs P.

“…Macrophages are prominent components of human atherosclerotic lesions and they are believed to accelerate the progression and/or complications of both early…”
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Oxidized or acetylated low density lipoproteins are rapidly cleared by the liver in mice with disruption of the scavenger receptor class A type I/II gene by Ling, W, Lougheed, M, Suzuki, H, Buchan, A, Kodama, T, Steinbrecher, U P

“…Oxidized low density lipoprotein (LDL) and acetyl LDL are recognized by the scavenger receptor class A type I/II (SR-AI/II) on macrophages and liver…”
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Uptake of Oxidized LDL by Macrophages Differs From That of Acetyl LDL and Leads to Expansion of an Acidic Endolysosomal Compartment by Lougheed, Marilee, Moore, Edwin D.W, Scriven, David R.L, Steinbrecher, Urs P

“…Accumulation of cholesterol by macrophage foam cells in atherosclerotic lesions is thought to involve the uptake of modified low density lipoproteins (LDLs)…”
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Oxidized Low-density Lipoprotein Inhibits Endothelium-dependent Vasodilation by an Antioxidant-sensitive, Lysophosphatidylcholine-independent Mechanism by Chan, Holman, Lougheed, Marilee, Laher, Ismail, Steinbrecher, Urs P

“…Previous studies have shown that oxidized low-density lipoprotein (LDL) can impair endothelial function and that this can be overcome in vivo by administration…”
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Oxidized low density lipoprotein is resistant to cathepsins and accumulates within macrophages by Lougheed, M, Zhang, H F, Steinbrecher, U P

“…The rate of uptake of oxidized low density lipoprotein (LDL) by mouse peritoneal macrophages is similar to that of acetyl LDL; but only approximately 50% of…”
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Oxidized Low-density Lipoprotein Inhibits Endothelium-dependent Vasodilation by an Antioxidant-sensitive, Lysophosphatidylcholine-independent Mechanism by Chan, Holman, Lougheed, Marilee, Laher, Ismail, Steinbrecher, Urs P.

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Inhibition of hydroxymethylglutaryl coenzyme A reductase activity does not affect the secretion rate of apolipoproteins B and AI by CaCo-2 cells by Pau, E, He, Y, Lougheed, M, Steinbrecher, U P

“…It is believed that the major mechanisms by which hydroxymethylglutaryl coenzyme A reductase inhibitors lower plasma cholesterol levels are by inducing hepatic…”
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