Search Results - "Lough, Rachel"

Rationally Designed High-Affinity 2-Amino-6-halopurine Heat Shock Protein 90 Inhibitors That Exhibit Potent Antitumor Activity by Kasibhatla, Srinivas R, Hong, Kevin, Biamonte, Marco A, Busch, David J, Karjian, Patricia L, Sensintaffar, John L, Kamal, Adeela, Lough, Rachel E, Brekken, John, Lundgren, Karen, Grecko, Roy, Timony, Gregg A, Ran, Yingqing, Mansfield, Robert, Fritz, Lawrence C, Ulm, Edgar, Burrows, Francis J, Boehm, Marcus F

“…Heat shock protein 90 (Hsp90) is a molecular chaperone protein implicated in stabilizing the conformation and maintaining the function of many cell-signaling…”
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7‘-Substituted Benzothiazolothio- and Pyridinothiazolothio-Purines as Potent Heat Shock Protein 90 Inhibitors by Zhang, Lin, Fan, Junhua, Vu, Khang, Hong, Kevin, Le Brazidec, Jean-Yves, Shi, Jiandong, Biamonte, Marco, Busch, David J, Lough, Rachel E, Grecko, Roy, Ran, Yingqing, Sensintaffar, John L, Kamal, Adeela, Lundgren, Karen, Burrows, Francis J, Mansfield, Robert, Timony, Gregg A, Ulm, Edgar H, Kasibhatla, Srinivas R, Boehm, Marcus F

“…We report on the discovery of benzo- and pyridino- thiazolothiopurines as potent heat shock protein 90 inhibitors. The benzothiazole moiety is exceptionally…”
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Orally Active Purine-Based Inhibitors of the Heat Shock Protein 90 by Biamonte, Marco A, Shi, Jiandong, Hong, Kevin, Hurst, David C, Zhang, Lin, Fan, Junhua, Busch, David J, Karjian, Patricia L, Maldonado, Angelica A, Sensintaffar, John L, Yang, Yong-Ching, Kamal, Adeela, Lough, Rachel E, Lundgren, Karen, Burrows, Francis J, Timony, Gregg A, Boehm, Marcus F, Kasibhatla, Srinivas R

“…Orally active Hsp90 inhibitors are of interest as potential chemotherapeutic agents. Recently, fully synthetic 8-benzyladenines and 8-sulfanyladenines such as…”
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The topoisomerase II–Hsp90 complex: A new chemotherapeutic target? by Barker, Catherine R., Hamlett, Jane, Pennington, Stephen R., Burrows, Francis, Lundgren, Karen, Lough, Rachel, Watson, Alastair J.M., Jenkins, John R.

“…The modulation of DNA topology by topoisomerase II plays a crucial role during chromosome condensation and segregation in mitosis and has thus become a highly…”
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BIIB021, a synthetic Hsp90 inhibitor, has broad application against tumors with acquired multidrug resistance by Zhang, Hong, Neely, Laura, Lundgren, Karen, Yang, Yong‐Ching, Lough, Rachel, Timple, Noel, Burrows, Francis

“…17‐AAG, the first‐generation clinical Hsp90 inhibitor, exhibits promising antitumor activity in clinical studies, but is limited by poor solubility and…”
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EC144 Is a Potent Inhibitor of the Heat Shock Protein 90 by Shi, Jiandong, Van de Water, Ryan, Hong, Kevin, Lamer, Ryan B, Weichert, Kenneth W, Sandoval, Cristina M, Kasibhatla, Srinivas R, Boehm, Marcus F, Chao, Jianhua, Lundgren, Karen, Timple, Noelito, Lough, Rachel, Ibanez, Gerardo, Boykin, Christina, Burrows, Francis J, Kehry, Marilyn R, Yun, Theodore J, Harning, Erin K, Ambrose, Christine, Thompson, Jeffrey, Bixler, Sarah A, Dunah, Anthone, Snodgrass-Belt, Pamela, Arndt, Joseph, Enyedy, Istvan J, Li, Ping, Hong, Victor S, McKenzie, Andres, Biamonte, Marco A

“…Alkyne 40, 5-(2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methylpent-4-yn-2-ol (EC144), is a second…”
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Synthesis and Biological Evaluation of a New Class of Geldanamycin Derivatives as Potent Inhibitors of Hsp90 by Le Brazidec, Jean-Yves, Kamal, Adeela, Busch, David, Thao, Lia, Zhang, Lin, Timony, Gregg, Grecko, Roy, Trent, Katy, Lough, Rachel, Salazar, Tim, Khan, Samina, Burrows, Francis, Boehm, Marcus F

“…The heat shock protein Hsp90 has increasingly become an important therapeutic target especially for treatment of cancers. Inhibition of the ATPase activity of…”
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