Search Results - "Lou, Zhiyong"

Structural basis and functional analysis of the SARS coronavirus nsp14–nsp10 complex by Ma, Yuanyuan, Wu, Lijie, Shaw, Neil, Gao, Yan, Wang, Jin, Sun, Yuna, Lou, Zhiyong, Yan, Liming, Zhang, Rongguang, Rao, Zihe

“…Nonstructural protein 14 (nsp14) of coronaviruses (CoV) is important for viral replication and transcription. The N-terminal exoribonuclease (ExoN) domain…”
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Structure of the RNA-dependent RNA polymerase from COVID-19 virus by Gao, Yan, Yan, Liming, Huang, Yucen, Liu, Fengjiang, Zhao, Yao, Cao, Lin, Wang, Tao, Sun, Qianqian, Ming, Zhenhua, Zhang, Lianqi, Ge, Ji, Zheng, Litao, Zhang, Ying, Wang, Haofeng, Zhu, Yan, Zhu, Chen, Hu, Tianyu, Hua, Tian, Zhang, Bing, Yang, Xiuna, Li, Jun, Yang, Haitao, Liu, Zhijie, Xu, Wenqing, Guddat, Luke W, Wang, Quan, Lou, Zhiyong, Rao, Zihe

“…A novel coronavirus [severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2)] outbreak has caused a global coronavirus disease 2019 (COVID-19) pandemic,…”
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Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase by Wang, Quan, Wu, Jiqin, Wang, Haofeng, Gao, Yan, Liu, Qiaojie, Mu, An, Ji, Wenxin, Yan, Liming, Zhu, Yan, Zhu, Chen, Fang, Xiang, Yang, Xiaobao, Huang, Yucen, Gao, Hailong, Liu, Fengjiang, Ge, Ji, Sun, Qianqian, Yang, Xiuna, Xu, Wenqing, Liu, Zhijie, Yang, Haitao, Lou, Zhiyong, Jiang, Biao, Guddat, Luke W., Gong, Peng, Rao, Zihe

“…Nucleotide analog inhibitors, including broad-spectrum remdesivir and favipiravir, have shown promise in in vitro assays and some clinical studies for COVID-19…”
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Structural and Biochemical Characterization of Endoribonuclease Nsp15 Encoded by Middle East Respiratory Syndrome Coronavirus by Zhang, Lianqi, Li, Lei, Yan, Liming, Ming, Zhenhua, Jia, Zhihui, Lou, Zhiyong, Rao, Zihe

“…Nonstructural protein 15 (Nsp15) encoded by coronavirus (CoV) is a nidoviral uridylate-specific endoribonuclease (NendoU) that plays an essential role in the…”
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Architecture of a SARS-CoV-2 mini replication and transcription complex by Yan, Liming, Zhang, Ying, Ge, Ji, Zheng, Litao, Gao, Yan, Wang, Tao, Jia, Zhihui, Wang, Haofeng, Huang, Yucen, Li, Mingyu, Wang, Quan, Rao, Zihe, Lou, Zhiyong

“…Non-structural proteins (nsp) constitute the SARS-CoV-2 replication and transcription complex (RTC) to play a pivotal role in the virus life cycle. Here we…”
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An electron transfer path connects subunits of a mycobacterial respiratory supercomplex by Gong, Hongri, Li, Jun, Xu, Ao, Tang, Yanting, Ji, Wenxin, Gao, Ruogu, Wang, Shuhui, Yu, Lu, Tian, Changlin, Li, Jingwen, Yen, Hsin-Yung, Man Lam, Sin, Shui, Guanghou, Yang, Xiuna, Sun, Yuna, Li, Xuemei, Jia, Minze, Yang, Cheng, Jiang, Biao, Lou, Zhiyong, Robinson, Carol V, Wong, Luet-Lok, Guddat, Luke W, Sun, Fei, Wang, Quan, Rao, Zihe

“…We report a 3.5-angstrom-resolution cryo-electron microscopy structure of a respiratory supercomplex isolated from It comprises a complex III dimer flanked on…”
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A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes by Guo, Yu, Huang, Lisu, Zhang, Guangshun, Yao, Yanfeng, Zhou, He, Shen, Shu, Shen, Bingqing, Li, Bo, Li, Xin, Zhang, Qian, Chen, Mingjie, Chen, Da, Wu, Jia, Fu, Dan, Zeng, Xinxin, Feng, Mingfang, Pi, Chunjiang, Wang, Yuan, Zhou, Xingdong, Lu, Minmin, Li, Yarong, Fang, Yaohui, Lu, Yun-Yueh, Hu, Xue, Wang, Shanshan, Zhang, Wanju, Gao, Ge, Adrian, Francisco, Wang, Qisheng, Yu, Feng, Peng, Yun, Gabibov, Alexander G., Min, Juan, Wang, Yuhui, Huang, Heyu, Stepanov, Alexey, Zhang, Wei, Cai, Yan, Liu, Junwei, Yuan, Zhiming, Zhang, Chen, Lou, Zhiyong, Deng, Fei, Zhang, Hongkai, Shan, Chao, Schweizer, Liang, Sun, Kun, Rao, Zihe

“…COVID-19 pandemic caused by SARS-CoV-2 constitutes a global public health crisis with enormous economic consequences. Monoclonal antibodies against SARS-CoV-2…”
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Structural basis of the recognition of adeno-associated virus by the neurological system-related receptor carbonic anhydrase IV by Zhang, Ran, Liu, Yixiao, Yu, Fengxi, Xu, Guangxue, Li, Lili, Li, Baobin, Lou, Zhiyong

“…Carbonic anhydrase IV (Car4) is a newly identified receptor that allows adeno-associated virus (AAV) 9P31 to cross the blood-brain barrier and achieve…”
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Divergent engagements between adeno-associated viruses with their cellular receptor AAVR by Zhang, Ran, Xu, Guangxue, Cao, Lin, Sun, Zixian, He, Yong, Cui, Mengtian, Sun, Yuna, Li, Shentao, Li, Huapeng, Qin, Lan, Hu, Mingxu, Yuan, Zhengjia, Rao, Zipei, Ding, Wei, Rao, Zihe, Lou, Zhiyong

“…Adeno-associated virus (AAV) receptor (AAVR) is an essential receptor for the entry of multiple AAV serotypes with divergent rules; however, the mechanism…”
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Structural perspective on the formation of ribonucleoprotein complex in negative-sense single-stranded RNA viruses by Zhou, Honggang, Sun, Yuna, Guo, Yu, Lou, Zhiyong

“…Highlights • Ribonucleoprotein (RNP) plays essential roles in the life cycles of negative-sense single-stranded RNA viruses (NSRVs). • RNP formation in NSRVs…”
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Structural analysis of a trimeric assembly of the mitochondrial dynamin-like GTPase Mgm1 by Yan, Liming, Qi, Yuanbo, Ricketson, Derek, Li, Lei, Subramanian, Kelly, Zhao, Jinghua, Yu, Caiting, Wu, Lijie, Sarsam, Reta, Wong, Melissa, Lou, Zhiyong, Rao, Zihe, Nunnari, Jodi, Hu, Junjie

“…The fusion of inner mitochondrial membranes requires dynamin-like GTPases, Mgm1 in yeast and OPA1 in mammals, but how they mediate membrane fusion is poorly…”
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A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71 by Wang, Xiangxi, Peng, Wei, Ren, Jingshan, Hu, Zhongyu, Xu, Jiwei, Lou, Zhiyong, Li, Xumei, Yin, Weidong, Shen, Xinliang, Porta, Claudine, Walter, Thomas S, Evans, Gwyndaf, Axford, Danny, Owen, Robin, Rowlands, David J, Wang, Junzhi, Stuart, David I, Fry, Elizabeth E, Rao, Zihe

“…Enterovirus 71 (EV71) is a major agent of hand, foot and mouth disease in children, but no vaccine or antiviral therapy is available. Structural analysis of…”
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Structural View and Substrate Specificity of Papain-like Protease from Avian Infectious Bronchitis Virus by Kong, Lingying, Shaw, Neil, Yan, Lingming, Lou, Zhiyong, Rao, Zihe

“…Papain-like protease (PLpro) of coronaviruses (CoVs) carries out proteolytic maturation of non-structural proteins that play a role in replication of the virus…”
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The newly emerged SARS-Like coronavirus HCoV-EMC also has an “Achilles’ heel”: current effective inhibitor targeting a 3C-like protease by Ren, Zhilin, Yan, Liming, Zhang, Ning, Guo, Yu, Yang, Cheng, Lou, Zhiyong, Rao, Zihe

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Structural basis for the neurotropic AAV9 and the engineered AAVPHP.eB recognition with cellular receptors by Xu, Guangxue, Zhang, Ran, Li, Huapeng, Yin, Kaixin, Ma, Xinyi, Lou, Zhiyong

“…Clade F adeno-associated virus (AAV) 9 has been utilized as therapeutic gene delivery vector, and it is capable of crossing blood brain barrier (BBB)…”
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Structures of Foot-and-mouth Disease Virus with neutralizing antibodies derived from recovered natural host reveal a mechanism for cross-serotype neutralization by He, Yong, Li, Kun, Cao, Yimei, Sun, Zixian, Li, Pinghua, Bao, Huifang, Wang, Sheng, Zhu, Guoqiang, Bai, Xingwen, Sun, Pu, Liu, Xuerong, Yang, Cheng, Liu, Zaixin, Lu, Zengjun, Rao, Zihe, Lou, Zhiyong

“…The development of a universal vaccine against foot-and-mouth disease virus (FMDV) is hindered by cross-serotype antigenic diversity and by a lack of knowledge…”
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Structural basis for the impact of phosphorylation on the activation of plant receptor-like kinase BAK1 by Yan, Liming, Ma, Yuanyuan, Liu, Dan, Wei, Xiaochao, Sun, Yuna, Chen, Xiaoyue, Zhao, Huadong, Zhou, Jingwen, Wang, Zhiyong, Shui, Wenqing, Lou, Zhiyong

“…Dear Editor, Receptor-like kinases （RLKs） constitute the major family of cell surface-associated receptors in plants and play essential roles in perceiving…”
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Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes by Fu, Dan, Zhang, Guangshun, Wang, Yuhui, Zhang, Zheng, Hu, Hengrui, Shen, Shu, Wu, Jun, Li, Bo, Li, Xin, Fang, Yaohui, Liu, Jia, Wang, Qiao, Zhou, Yunjiao, Wang, Wei, Li, Yufeng, Lu, Zhonghua, Wang, Xiaoxiao, Nie, Cui, Tian, Yujie, Chen, Da, Wang, Yuan, Zhou, Xingdong, Wang, Qisheng, Yu, Feng, Zhang, Chen, Deng, Changjing, Zhou, Liang, Guan, Guangkuo, Shao, Na, Lou, Zhiyong, Deng, Fei, Zhang, Hongkai, Chen, Xinwen, Wang, Manli, Liu, Louis, Rao, Zihe, Guo, Yu

“…The ongoing Coronavirus Disease 2019 (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) threatens global public health…”
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Structural Basis for the Recognition of Blood Group Trisaccharides by Norovirus by Cao, Sheng, Lou, Zhiyong, Tan, Ming, Chen, Yutao, Liu, Yijin, Zhang, Zhushan, Zhang, Xuejun C, Jiang, Xi, Li, Xuemei, Rao, Zihe

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Crystal structure of the polymerase PAC–PB1N complex from an avian influenza H5N1 virus by He, Xiaojing, Zhou, Jie, Bartlam, Mark, Zhang, Rongguang, Ma, Jianyuan, Lou, Zhiyong, Li, Xuemei, Li, Jingjing, Joachimiak, Andrzej, Zeng, Zonghao, Ge, Ruowen, Rao, Zihe, Liu, Yingfang

“…Influenza virus: polymerase structures determined Influenza A virus polymerase consists of three proteins, PA, PB1 and PB2, and is critical for transcription…”
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