Search Results - "Lou, Wenjia"
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A randomized controlled study of vaginal fractional CO2 laser therapy for female sexual dysfunction
Published in Lasers in medical science (01-02-2022)“…The purpose of this study is to evaluate the efficacy and safety of vaginal fractional CO 2 laser therapy for female sexual dysfunction (FSD). A total of 84…”
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Loss of tafazzin results in decreased myoblast differentiation in C2C12 cells: A myoblast model of Barth syndrome and cardiolipin deficiency
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01-08-2018)“…Barth syndrome (BTHS) is an X-linked genetic disorder resulting from mutations in the tafazzin gene (TAZ), which encodes the transacylase that remodels the…”
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3
CHD7 promotes neural progenitor differentiation in embryonic stem cells via altered chromatin accessibility and nascent gene expression
Published in Scientific reports (15-10-2020)“…CHARGE syndrome, a rare multiple congenital anomaly condition, is caused by haploinsufficiency of the chromatin remodeling protein gene CHD7 (Chromodomain…”
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4
Directed evolution of conformation‐specific antibodies for sensitive detection of polypeptide aggregates in therapeutic drug formulations
Published in Biotechnology and bioengineering (01-02-2021)“…Biologics such as peptides and proteins possess a number of attractive attributes that make them particularly valuable as therapeutics, including their high…”
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Reduction of therapeutic antibody self-association using yeast-display selections and machine learning
Published in mAbs (2022)“…Self-association governs the viscosity and solubility of therapeutic antibodies in high-concentration formulations used for subcutaneous delivery, yet it is…”
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De novo urinary incontinence and lower urinary tract symptoms after colpocleisis: A single-center prospective study
Published in Heliyon (30-05-2024)“…Colpocleisis is one of traditional surgical procedures for elderly and frail women with advanced pelvic organ prolapse. The occurrence of de novo urinary…”
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Lipidomics Characterization of Biosynthetic and Remodeling Pathways of Cardiolipins in Genetically and Nutritionally Manipulated Yeast Cells
Published in ACS chemical biology (20-01-2017)“…Cardioipins (CLs) are unique tetra-acylated phospholipids of mitochondria and define the bioenergetics and regulatory functions of these organelles. An…”
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Potent Antitumor Activity in Experimental Hepatocellular Carcinoma by Adenovirus-Mediated Coexpression of TRAIL and shRNA against COX-2
Published in Clinical cancer research (15-07-2010)“…Recent studies have indicated that short hairpin RNA (shRNA) driven by RNA polymerase (Pol) II promoters can be transcribed into precursor mRNAs together with…”
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Deletion of the Cardiolipin-specific Phospholipase Cld1 Rescues Growth and Life Span Defects in the Tafazzin Mutant
Published in The Journal of biological chemistry (01-02-2014)“…Cardiolipin (CL) that is synthesized de novo is deacylated to monolysocardiolipin (MLCL), which is reacylated by tafazzin. Remodeled CL contains mostly…”
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Anatomic and Sexual Outcomes after Vaginoplasty Using Tissue‐Engineered Biomaterial Graft in Patients with Mayer‐Rokitansky‐Küster‐Hauser Syndrome: A New Minimally Invasive and Effective Surgery
Published in Journal of sexual medicine (01-06-2013)“…Recent years have seen continuous reports about the successful reconstruction of numerous organs with the application of tissue‐engineering techniques. Thus,…”
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Cardiolipin-induced activation of pyruvate dehydrogenase links mitochondrial lipid biosynthesis to TCA cycle function
Published in The Journal of biological chemistry (26-07-2019)“…Cardiolipin (CL) is the signature phospholipid of mitochondrial membranes. Although it has long been known that CL plays an important role in mitochondrial…”
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Cardiolipin-deficient cells have decreased levels of the iron–sulfur biogenesis protein frataxin
Published in The Journal of biological chemistry (14-08-2020)“…Cardiolipin (CL) is the signature phospholipid of mitochondrial membranes, where it is synthesized locally and plays an important role in mitochondrial…”
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13
Oncolytic adenovirus co-expressing miRNA-34a and IL-24 induces superior antitumor activity in experimental tumor model
Published in Journal of molecular medicine (Berlin, Germany) (01-06-2013)“…It has been demonstrated that numerous microRNAs (miRNAs) have potent tumor-suppressing effects on a variety of cancers, implicating a possible application of…”
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Deletion of the cardiolipin-specific phospholipase Cld1 rescues growth and life span defects in the tafazzin mutant: implications for Barth syndrome
Published in The Journal of biological chemistry (07-02-2014)“…Cardiolipin (CL) that is synthesized de novo is deacylated to monolysocardiolipin (MLCL), which is reacylated by tafazzin. Remodeled CL contains mostly…”
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Journal Article -
15
Female urinary incontinence in China after 15 years’ efforts: Results from large-scale nationwide surveys
Published in Science bulletin (Beijing) (30-10-2024)“…[Display omitted] Urinary incontinence (UI) is a disease that quietly yet seriously impacts women’s health and represents a global health burden that is often…”
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Journal Article -
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A randomized controlled study of vaginal fractional CO 2 laser therapy for female sexual dysfunction
Published in Lasers in medical science (01-02-2022)“…The purpose of this study is to evaluate the efficacy and safety of vaginal fractional CO laser therapy for female sexual dysfunction (FSD). A total of 84…”
Get full text
Journal Article -
17
Genetic re-engineering of polyunsaturated phospholipid profile of Saccharomyces cerevisiae identifies a novel role for Cld1 in mitigating the effects of cardiolipin peroxidation
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01-10-2018)“…Cardiolipin (CL) is a unique phospholipid localized almost exclusively within the mitochondrial membranes where it is synthesized. Newly synthesized CL…”
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Novel Functions of Cardiolipin Remodeling in Saccharomyces Cerevisiae and Mammalian Cells: Implications for Barth Syndrome
Published 01-01-2017“…Cardiolipin (CL) is a unique phospholipid that is primarily localized within the inner mitochondrial membrane. Newly synthesized CL undergoes acyl remodeling…”
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Dissertation -
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TCA Cycle Defects in Barth Syndrome
Published in The FASEB journal (01-04-2016)“…Abstract only Barth syndrome (BTHS) is a genetic disorder caused by defective remodeling of the phospholipid cardiolipin (CL) due to mutations in the gene…”
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Journal Article -
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Deletion of the cardiolipin‐specific phospholipase Cld1 rescues growth and lifespan defects in the tafazzin mutant: implications for Barth syndrome (605.4)
Published in The FASEB journal (01-04-2014)“…Cardiolipin (CL) that is synthesized de novo is deacylated to monolysocardiolipin (MLCL), which is reacylated by tafazzin. Remodeled CL contains mostly…”
Get full text
Journal Article