Search Results - "Lou, Kevin"

Phase 2 study of pembrolizumab in patients with recurrent and residual high-grade meningiomas by Brastianos, Priscilla K., Kim, Albert E., Giobbie-Hurder, Anita, Lee, Eudocia Quant, Wang, Nancy, Eichler, April F., Chukwueke, Ugonma, Forst, Deborah A., Arrillaga-Romany, Isabel C., Dietrich, Jorg, Corbin, Zachary, Moliterno, Jennifer, Baehring, Joachim, White, Michael, Lou, Kevin W., Larson, Juliana, de Sauvage, Magali A., Evancic, Kathryn, Mora, Joana, Nayyar, Naema, Loeffler, Jay, Oh, Kevin, Shih, Helen A., Curry, William T., Cahill, Daniel P., Barker, Fred G., Gerstner, Elizabeth R., Santagata, Sandro

“…High-grade meningiomas are associated with neuro-cognitive morbidity and have limited treatments. High-grade meningiomas harbor an immunosuppressive tumor…”
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Brain-Penetrant, Orally Bioavailable Microtubule-Stabilizing Small Molecules Are Potential Candidate Therapeutics for Alzheimer’s Disease and Related Tauopathies by Lou, Kevin, Yao, Yuemang, Hoye, Adam T, James, Michael J, Cornec, Anne-Sophie, Hyde, Edward, Gay, Bryant, Lee, Virginia M.-Y, Trojanowski, John Q, Smith, Amos B, Brunden, Kurt R, Ballatore, Carlo

“…Microtubule (MT) stabilizing drugs hold promise as potential treatments for Alzheimer’s disease (AD) and related tauopathies. However, thus far epothilone D…”
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Abnormal vascular structure and function within brain metastases is linked to pembrolizumab resistance by Kim, Albert E, Lou, Kevin W, Giobbie-Hurder, Anita, Chang, Ken, Gidwani, Mishka, Hoebel, Katharina, Patel, Jay B, Cleveland, Mason C, Singh, Praveer, Bridge, Christopher P, Ahmed, Syed Rakin, Bearce, Benjamin A, Liu, William, Fuster-Garcia, Elies, Lee, Eudocia Q, Lin, Nancy U, Overmoyer, Beth, Wen, Patrick Y, Nayak, Lakshmi, Cohen, Justine V, Dietrich, Jorg, Eichler, April, Heist, Rebecca, Krop, Ian, Lawrence, Donald, Ligibel, Jennifer, Tolaney, Sara, Mayer, Erica, Winer, Eric, Perrino, Carmen M, Summers, Elizabeth J, Mahar, Maura, Oh, Kevin, Shih, Helen A, Cahill, Daniel P, Rosen, Bruce R, Yen, Yi-Fen, Kalpathy-Cramer, Jayashree, Martinez-Lage, Maria, Sullivan, Ryan J, Brastianos, Priscilla K, Emblem, Kyrre E, Gerstner, Elizabeth R

“…Abstract Background We recently conducted a phase 2 trial (NCT028865685) evaluating intracranial efficacy of pembrolizumab for brain metastases (BM) of diverse…”
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Osimertinib-induced biventricular cardiomyopathy with abnormal cardiac MRI findings: a case report by Patel, Karishma, Hsu, Kristie Y., Lou, Kevin, Soni, Krishan, Lee, Yoo Jin, Mulvey, Claire K., Baik, Alan H.

“…Abstract Background Osimertinib is a third-generation epidermal growth factor receptor (EGFR) inhibitor that is currently the first-line treatment for…”
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Correction: Osimertinib-induced biventricular cardiomyopathy with abnormal cardiac MRI findings: a case report by Patel, Karishma, Hsu, Kristie Y., Lou, Kevin, Soni, Krishan, Lee, Yoo Jin, Mulvey, Claire K., Baik, Alan H.

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Alcohol, nicotine, and COVID-19: A retrospective study of health outcomes in central Pennsylvania by Xu, Kevin Lou, Randall, Patrick Arthur

“…Individuals with substance abuse disorder are at increased risk for the development of severe disease following COVID-19 infection. Furthermore, individuals in…”
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Brain-restricted mTOR inhibition with binary pharmacology by Zhang, Ziyang, Fan, Qiwen, Luo, Xujun, Lou, Kevin, Weiss, William A., Shokat, Kevan M.

“…On-target–off-tissue drug engagement is an important source of adverse effects that constrains the therapeutic window of drug candidates 1 , 2 . In diseases of…”
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A SARS-CoV-2 protein interaction map reveals targets for drug repurposing by Gordon, David E., Jang, Gwendolyn M., Bouhaddou, Mehdi, Xu, Jiewei, Obernier, Kirsten, White, Kris M., O’Meara, Matthew J., Rezelj, Veronica V., Guo, Jeffrey Z., Swaney, Danielle L., Tummino, Tia A., Kaake, Robyn M., Richards, Alicia L., Tutuncuoglu, Beril, Foussard, Helene, Haas, Kelsey, Modak, Maya, Haas, Paige, Braberg, Hannes, Fabius, Jacqueline M., Eckhardt, Manon, Bennett, Melanie J., Cakir, Merve, McGregor, Michael J., Li, Qiongyu, Roesch, Ferdinand, Vallet, Thomas, Mac Kain, Alice, Miorin, Lisa, Moreno, Elena, Naing, Zun Zar Chi, Zhou, Yuan, Peng, Shiming, Shi, Ying, Zhang, Ziyang, Shen, Wenqi, Kirby, Ilsa T., Melnyk, James E., Chorba, John S., Lou, Kevin, Dai, Shizhong A., Barrio-Hernandez, Inigo, Memon, Danish, Hernandez-Armenta, Claudia, Perica, Tina, Ganesan, Sai J., Saltzberg, Daniel J., Calviello, Lorenzo, Venkataramanan, Srivats, Lin, Yizhu, Liu, YongFeng, Wankowicz, Stephanie A., Bohn, Markus, Safari, Maliheh, Ugur, Fatima S., Koh, Cassandra, Savar, Nastaran Sadat, Tran, Quang Dinh, Fletcher, Sabrina J., Cai, Yiming, Chang, Jason C. J., Broadhurst, David J., Klippsten, Saker, Sharp, Phillip P., Kuzuoglu-Ozturk, Duygu, Wang, Hao-Yuan, Trenker, Raphael, Cavero, Devin A., Hiatt, Joseph, Roth, Theodore L., Rathore, Ujjwal, Subramanian, Advait, Noack, Julia, Hubert, Mathieu, Stroud, Robert M., Frankel, Alan D., Verba, Kliment A., Agard, David A., Emerman, Michael, Jura, Natalia, von Zastrow, Mark, Verdin, Eric, Ashworth, Alan, Schwartz, Olivier, Mukherjee, Shaeri, Jacobson, Matt, Fujimori, Danica G., Ideker, Trey, Craik, Charles S., Floor, Stephen N., Fraser, James S., Gross, John D., Roth, Bryan L., Ruggero, Davide, Taunton, Jack, Beltrao, Pedro, Vignuzzi, Marco, Shokat, Kevan M., Shoichet, Brian K., Krogan, Nevan J.

“…A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of coronavirus disease 2019…”
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A SARS-CoV-2 protein interaction map reveals targets for drug repurposing by Gordon, David E, Jang, Gwendolyn M, Bouhaddou, Mehdi, Xu, Jiewei, Obernier, Kirsten, White, Kris M, O'Meara, Matthew J, Rezelj, Veronica V, Guo, Jeffrey Z, Swaney, Danielle L, Tummino, Tia A, Hüttenhain, Ruth, Kaake, Robyn M, Richards, Alicia L, Tutuncuoglu, Beril, Foussard, Helene, Batra, Jyoti, Haas, Kelsey, Modak, Maya, Kim, Minkyu, Haas, Paige, Polacco, Benjamin J, Braberg, Hannes, Fabius, Jacqueline M, Eckhardt, Manon, Soucheray, Margaret, Bennett, Melanie J, Cakir, Merve, McGregor, Michael J, Li, Qiongyu, Meyer, Bjoern, Roesch, Ferdinand, Vallet, Thomas, Mac Kain, Alice, Miorin, Lisa, Moreno, Elena, Naing, Zun Zar Chi, Zhou, Yuan, Peng, Shiming, Shi, Ying, Zhang, Ziyang, Shen, Wenqi, Kirby, Ilsa T, Melnyk, James E, Chorba, John S, Lou, Kevin, Dai, Shizhong A, Barrio-Hernandez, Inigo, Memon, Danish, Hernandez-Armenta, Claudia, Lyu, Jiankun, Mathy, Christopher J P, Perica, Tina, Pilla, Kala Bharath, Ganesan, Sai J, Saltzberg, Daniel J, Rakesh, Ramachandran, Liu, Xi, Rosenthal, Sara B, Calviello, Lorenzo, Venkataramanan, Srivats, Liboy-Lugo, Jose, Lin, Yizhu, Huang, Xi-Ping, Liu, YongFeng, Wankowicz, Stephanie A, Bohn, Markus, Safari, Maliheh, Ugur, Fatima S, Koh, Cassandra, Savar, Nastaran Sadat, Tran, Quang Dinh, Shengjuler, Djoshkun, Fletcher, Sabrina J, O'Neal, Michael C, Cai, Yiming, Chang, Jason C J, Broadhurst, David J, Klippsten, Saker, Sharp, Phillip P, Wenzell, Nicole A, Kuzuoglu-Ozturk, Duygu, Wang, Hao-Yuan, Trenker, Raphael, Young, Janet M, Cavero, Devin A, Hiatt, Joseph, Roth, Theodore L, Rathore, Ujjwal, Subramanian, Advait, Noack, Julia, Hubert, Mathieu, Stroud, Robert M, Frankel, Alan D, Rosenberg, Oren S, Verba, Kliment A, Agard, David A, Ott, Melanie, Emerman, Michael, Jura, Natalia

“…A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of coronavirus disease 2019…”
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p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition by Guiley, Keelan Z, Stevenson, Jack W, Lou, Kevin, Barkovich, Krister J, Kumarasamy, Vishnu, Wijeratne, Tilini U, Bunch, Katharine L, Tripathi, Sarvind, Knudsen, Erik S, Witkiewicz, Agnieszka K, Shokat, Kevan M, Rubin, Seth M

“…The p27 protein is a canonical negative regulator of cell proliferation and acts primarily by inhibiting cyclin-dependent kinases (CDKs). Under some…”
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20-year trends in perioperative outcomes in patients with bladder cancer undergoing radical cystectomy with ileal conduit urinary diversion by Xu, Kevin Lou, Ryu, Grace, Makarova, Elizaveta, Bakhl, Katrina, Boltz, Suzanne, Demirsoy, Seyma, Raman, Jay D., Truong, Hong

“…583 Background: Radical cystectomy is associated with considerable postoperative morbidities. Enhanced recovery after surgery protocol is a multimodal…”
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Investigating Therapeutic Chemotypes by Merging Functional Genomics and Drug Design by Lou, Kevin

“…Biologically active compounds exert their effects on living systems by binding to and modulating particular nodes among a vast network of macromolecules within…”
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A Bounty of New Challenging Targets in Oncology for Chemical Discovery by Lou, Kevin, Gilbert, Luke A, Shokat, Kevan M

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IFITM proteins assist cellular uptake of diverse linked chemotypes by Lou, Kevin, Wassarman, Douglas R, Yang, Tangpo, Paung, YiTing, Zhang, Ziyang, O'Loughlin, Thomas A, Moore, Megan K, Egan, Regina K, Greninger, Patricia, Benes, Cyril H, Seeliger, Markus A, Taunton, Jack, Gilbert, Luke A, Shokat, Kevan M

“…The search for cell-permeable drugs has conventionally focused on low-molecular weight (MW), nonpolar, rigid chemical structures. However, emerging therapeutic…”
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Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib by Leyte-Vidal, Ariel, DeFilippis, RosaAnna, Outhwaite, Ian R., Kwan, Isabelle, Lee, Ji Young, Leavitt, Carlyn, Miller, Kaeli B., Rea, Delphine, Rangwala, Aziz M., Lou, Kevin, Patel, Suhana, Alvarez, Ailin, Shokat, Kevan M., Bahar, Ivet, Seeliger, Markus A., Shah, Neil P.

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Bavituximab Decreases Immunosuppressive Myeloid-Derived Suppressor Cells in Newly Diagnosed Glioblastoma Patients by Ly, K Ina, Richardson, Leland G, Liu, Mofei, Muzikansky, Alona, Cardona, Jonathan, Lou, Kevin, Beers, Andrew L, Chang, Ken, Brown, James M, Ma, Xiaoyue, Reardon, David A, Arrillaga-Romany, Isabel C, Forst, Deborah A, Jordan, Justin T, Lee, Eudocia Q, Dietrich, Jorg, Nayak, Lakshmi, Wen, Patrick Y, Chukwueke, Ugonma, Giobbie-Hurder, Anita, Choi, Bryan D, Batchelor, Tracy T, Kalpathy-Cramer, Jayashree, Curry, William T, Gerstner, Elizabeth R

“…We evaluated the efficacy of bavituximab-a mAb with anti-angiogenic and immunomodulatory properties-in newly diagnosed patients with glioblastoma (GBM) who…”
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Phase 2 trial of bavituximab with chemoradiation and adjuvant temozolomide in newly diagnosed glioblastoma by Ly, Ina, Richardson, Leland, Liu, Mofei, Muzikansky, Alona, Lou, Kevin, Reardon, David A., Arrillaga-Romany, Isabel, Forst, Deborah Anne, Jordan, Justin T., Lee, Eudocia Quant, Dietrich, Jorg, Nayak, Lakshmi, Wen, Patrick Y., Chukwueke, Ugonma Nnenna, Giobbie-Hurder, Anita, Choi, Bryan D., Batchelor, Tracy, Kalpathy-Cramer, Jayashree, Curry, William T., Gerstner, Elizabeth R.

“…2030 Background: Glioblastoma (GBM) and tumor endothelial cells express phosphatidylserine (PS), a highly immunosuppressive membrane phospholipid. PS receptors…”
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MRI changes in patients with newly diagnosed glioblastoma treated as part of a phase II trial with bavituximab, radiation, and temozolomide by Ly, Ina, Cardona, Jonathan, Lou, Kevin, Beers, Andrew, Chang, Ken, Brown, James, Reardon, David A., Arrillaga-Romany, Isabel, Forst, Deborah Anne, Jordan, Justin T, Lee, Eudocia Quant, Dietrich, Jorg, Nayak, Lakshmi, Wen, Patrick Y., Chukwueke, Ugonma Nnenna, Batchelor, Tracy, Curry, William T., Kalpathy-Cramer, Jayashree, Gerstner, Elizabeth Robins

“…Abstract only 2546 Background: Glioblastoma and tumor endothelial cells express phosphatidylserine (PS), a highly immunosuppressive membrane phospholipid…”
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CTIM-30. PHASE II TRIAL OF PEMBROLIZUMAB IN RECURRENT AND RESIDUAL HIGH-GRADE MENINGIOMAS by Brastianos, Priscilla, Kim, Albert, Giobbie-Hurder, Anita, Lee, Eudocia Quant, Wang, Nancy, Eichler, April, Chukwueke, Ugonma, Forst, Deborah, Arrillaga-Romany, Isabel, Dietrich, Jorg, Lou, Kevin, Larson, Juliana, Mora, Joana, Nayyar, Naema, Loeffler, Jay, Oh, Kevin, Shih, Helen, Curry, William, Cahill, Daniel, Barker, Fred, Gerstner, Elizabeth, Santagata, Sandro

“…Abstract INTRODUCTION High-grade meningiomas are associated with significant neuro-cognitive morbidity and a poor prognosis. Systemic therapies, to date, have…”
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Exploring the Relationship Between Hardiness and Performance in Collegiate Baseball Players by Lou, Kevin R

“…The purpose of this study was to explore the influence of the individual personality characteristic of hardiness on trait anxiety and objective performance…”
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