Search Results - "Lou, Jennifer W"

Atomic model for core modifying region of human fatty acid synthase in complex with Denifanstat by Hasan, S. M. Naimul, Lou, Jennifer W., Keszei, Alexander F. A., Dai, David L., Mazhab-Jafari, Mohammad T.

“…Fatty acid synthase (FASN) catalyzes the de novo synthesis of palmitate, a 16-carbon chain fatty acid that is the primary precursor of lipid metabolism and an…”
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Mitochondrial Metabolism of Pyruvate Is Essential for Regulating Glucose-stimulated Insulin Secretion by Patterson, Jessica N., Cousteils, Katelyn, Lou, Jennifer W., Manning Fox, Jocelyn E., MacDonald, Patrick E., Joseph, Jamie W.

“…It is well known that mitochondrial metabolism of pyruvate is critical for insulin secretion; however, we know little about how pyruvate is transported into…”
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Direct structural analysis of a single acyl carrier protein domain in fatty acid synthase from the fungus Saccharomyces cerevisiae by Samani, Elnaz Khalili, Chen, Amy C., Lou, Jennifer W., Dai, David L., Keszei, Alexander F. A., Tan, Guihong, Boone, Charles, Grininger, Martin, Mazhab-Jafari, Mohammad T.

“…Acyl carrier protein (ACP) is the work horse of polyketide (PKS) and fatty acid synthases (FAS) and acts as a substrate shuttling domain in these mega enzymes…”
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Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity by Iyer, Kali R, Li, Sheena C, Revie, Nicole M, Lou, Jennifer W, Duncan, Dustin, Fallah, Sara, Sanchez, Hiram, Skulska, Iwona, Ušaj, Mojca Mattiazzi, Safizadeh, Hamid, Larsen, Brett, Wong, Cassandra, Aman, Ahmed, Kiyota, Taira, Yoshimura, Mami, Kimura, Hiromi, Hirano, Hiroyuki, Yoshida, Minoru, Osada, Hiroyuki, Gingras, Anne-Claude, Andes, David R, Shapiro, Rebecca S, Robbins, Nicole, Mazhab-Jafari, Mohammad T, Whitesell, Luke, Yashiroda, Yoko, Boone, Charles, Cowen, Leah E

“…Rising drug resistance among pathogenic fungi, paired with a limited antifungal arsenal, poses an increasing threat to human health. To identify antifungal…”
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Electron cryomicroscopy observation of acyl carrier protein translocation in type I fungal fatty acid synthase by Lou, Jennifer W., Iyer, Kali R., Hasan, S. M. Naimul, Cowen, Leah E., Mazhab-Jafari, Mohammad T.

“…During fatty acid biosynthesis, acyl carrier proteins (ACPs) from type I fungal fatty acid synthase (FAS) shuttle substrates and intermediates within a…”
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Steric occlusion regulates proximal interactions of acyl carrier protein domain in fungal fatty acid synthase by Lou, Jennifer W., Mazhab-Jafari, Mohammad T.

“…The acyl carrier protein (ACP) domain shuttles substrates and reaction intermediates in type I fungal fatty acid synthases via transient protein-protein…”
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