Granule size control and targeting in pulsed spray fluid bed granulation

Granule size control and targeting in pulsed spray fluid bed granulation

The primary aim of the study was to investigate the effects of pulsed liquid feed on granule size. The secondary aim was to increase knowledge of this technique in granule size targeting. Pulsed liquid feed refers to the pump changing between on- and off-positions in sequences, called duty cycles. O...

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Bibliographic Details
Published in:International journal of pharmaceutics Vol. 377; no. 1; pp. 9 - 15
Main Authors: Ehlers, Henrik, Liu, Anchang, Räikkönen, Heikki, Hatara, Juha, Antikainen, Osmo, Airaksinen, Sari, Heinämäki, Jyrki, Lou, Honxiang, Yliruusi, Jouko
Format: Journal Article
Language:English
Published: Amsterdam Elsevier B.V 30-07-2009
Elsevier
Subjects:
Atomization pressure
Biological and medical sciences
Caffeine - analysis
Drug Delivery Systems - methods
Fluid bed granulation
General pharmacology
Granule size
Humidity
Inlet air relative humidity
Lactose - analysis
Medical sciences
Microscopy, Electron, Scanning
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physical Phenomena
Powders - analysis
Process control
Pulsed spray
Technology, Pharmaceutical - methods
Fluid bed granulation
Inlet air relative humidity
Atomization pressure
Pulsed spray
Process control
Granule size
Relative humidity
Pharmaceutical technology
Targeting
Granulation
Pressure
Target
Granule
Atomization
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Summary:The primary aim of the study was to investigate the effects of pulsed liquid feed on granule size. The secondary aim was to increase knowledge of this technique in granule size targeting. Pulsed liquid feed refers to the pump changing between on- and off-positions in sequences, called duty cycles. One duty cycle consists of one on- and off-period. The study was performed with a laboratory-scale top-spray fluid bed granulator with duty cycle length and atomization pressure as studied variables. The liquid feed rate, amount and inlet air temperature were constant. The granules were small, indicating that the powder has only undergone ordered mixing, nucleation and early growth. The effect of atomizing pressure on granule size depends on inlet air relative humidity, with premature binder evaporation as a reason. The duty cycle length was of critical importance to the end product attributes, by defining the extent of intermittent drying and rewetting. By varying only the duty cycle length, it was possible to control granule nucleation and growth, with a wider granule size target range in increased relative humidity. The present study confirms that pulsed liquid feed in fluid bed granulation is a useful tool in end product particle size targeting.
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content type line 23
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2009.04.041