Search Results - "Lotz, M.K"

Macroscopic and histopathologic analysis of human knee menisci in aging and osteoarthritis by Pauli, C, Grogan, S.P, Patil, S, Otsuki, S, Hasegawa, A, Koziol, J, Lotz, M.K, D’Lima, D.D

“…Summary Objective Meniscus lesions following trauma or associated with osteoarthritis (OA) have been described, yet meniscus aging has not been systematically…”
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Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis by Akasaki, Y, Hasegawa, A, Saito, M, Asahara, H, Iwamoto, Y, Lotz, M.K

“…Summary Objective Aging is a major risk factor for osteoarthritis (OA). Forkhead-box class O (FoxO) transcription factors regulate mechanisms of cellular…”
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Identification of transcription factors responsible for dysregulated networks in human osteoarthritis cartilage by global gene expression analysis by Fisch, K.M., Gamini, R., Alvarez-Garcia, O., Akagi, R., Saito, M., Muramatsu, Y., Sasho, T., Koziol, J.A., Su, A.I., Lotz, M.K.

“…Osteoarthritis (OA) is the most prevalent joint disease. As disease-modifying therapies are not available, novel therapeutic targets need to be discovered and…”
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MicroRNA-155 suppresses autophagy in chondrocytes by modulating expression of autophagy proteins by D'Adamo, S, Alvarez-Garcia, O, Muramatsu, Y, Flamigni, F, Lotz, M.K

“…Summary Objective Autophagy dysfunction has been reported in osteoarthritis (OA) cartilage. The objective of this study was to investigate the role of…”
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Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism by Shen, T, Alvarez-Garcia, O, Li, Y, Olmer, M, Lotz, M.K

“…Summary Objectives Aging is an important osteoarthritis (OA) risk factor and compromised stress defense responses may mediate this risk. The Sestrins (Sesn)…”
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TGFβ1 signaling protects chondrocytes against oxidative stress via FOXO1–autophagy axis by Kurakazu, I., Akasaki, Y., Tsushima, H., Sueishi, T., Toya, M., Kuwahara, M., Uchida, T., Lotz, M.K., Nakashima, Y.

“…The forkhead box O1 (FOXO1) transcription factor is a key regulator of autophagy. In chondrocytes, reduced FOXO1 expression with aging causes osteoarthritis…”
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Histopathological analyses of murine menisci: implications for joint aging and osteoarthritis by Kwok, J, Onuma, H, Olmer, M, Lotz, M.K, Grogan, S.P, D'Lima, D.D

“…Summary Objective To establish a standardized protocol for histopathological assessment of murine menisci that can be applied to evaluate transgenic,…”
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Comparison of cartilage histopathology assessment systems on human knee joints at all stages of osteoarthritis development by Pauli, C, Whiteside, R, Heras, F.L, Nesic, D, Koziol, J, Grogan, S.P, Matyas, J, Pritzker, K.P.H, D’Lima, D.D, Lotz, M.K

“…Abstract Objective To compare the MANKIN and OARSI cartilage histopathology assessment systems using human articular cartilage from a large number of donors…”
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Suppression of REDD1 in osteoarthritis cartilage, a novel mechanism for dysregulated mTOR signaling and defective autophagy by Alvarez-Garcia, Oscar, Olmer, Merissa, Akagi, Ryuichiro, Akasaki, Yukio, Fisch, Kathleen M, Shen, Tao, Su, Andrew I, Lotz, Martin K

“…Summary Objective Aging is a main risk factor for the development of osteoarthritis (OA) and the molecular mechanisms underlying the aging-related changes in…”
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The role of forkhead box o transcription factors in joint development, maturation and homeostasis by Matsuzaki, T, Olmer, M, Matsuzaki, O, Lotz, M.K

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Krüppel-like factors (KLFS), novel transcriptional regulators of articular chondrocytes that are abnormally expressed in osteoarthritic cartilage by Teramura, T, Hasei, J, Asahara, H, Lotz, M.K

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Differential metabolic effects of glucosamine and N -acetylglucosamine in human articular chondrocytes by Shikhman, A.R, Brinson, D.C, Valbracht, J, Lotz, M.K

“…Summary Objective Aminosugars are commonly used to treat osteoarthritis; however, molecular mechanisms mediating their anti-arthritic activities are still…”
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Transthyretin deposition accelerates the development of experimental osteoarthritis in mice by Matsuzaki, T, Alvarez-Garcia, O, Akasaki, Y, Reixach, N, Buxbaum, J, Lotz, M.K

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Suppression of sestrins in aging and osteoarthritic cartilage: Dysfunction of an important stress defense mechanism by Shen, T, Alvarez-Garcia, O, Li, Y, Olmer, M, Lotz, M.K

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Palmitate has proapoptotic and proinflammatory effects on articular cartilage and synergizes with interleukin-1 by Alvarez-Garcia, O, Rogers, N.H, Smith, R.G, Lotz, M.K

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TWIST1 promotes catabolic responses and abnormal differentiation in human chondrocytes by Hasei, J, Teramura, T, Olmer, M, Ozaki, T, Asahara, H, Lotz, M.K

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Differential DNA methylation and reduced expression of critical transcription factors in human oa cartilage by Alvarez-Garcia, O, Fisch, K.M, Akagi, R, Su, A.I, Lotz, M.K

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Suppression of REDD1 in OA cartilage, a novel mechanism for dysregulated mTOR activation by Alvarez-Garcia, O, Akagi, R, Akasaki, Y, Fisch, K.M, Su, A.I, Lotz, M.K

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Transthyretin and amyloid in cartilage aging and osteoarthritis by Akasaki, Y, Alvarez-Garcia, O, Reixach, N, Buxbaum, J.N, Iwamoto, Y, Lotz, M.K

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Human chondrocyte apoptosis in response to mechanical injury by D'lima, D.D., Hashimoto, S., Chen, P.C., Colwell, C.W., Lotz, M.K.

“…Objective The effect of mechanical injury on chondrocyte viability and matrix degradation was studied. It was proposed that mechanical injury to human…”
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