Search Results - "Lotz, Gregor"

Mutant Huntingtin Fragments Form Oligomers in a Polyglutamine Length-dependent Manner in Vitro and in Vivo by Legleiter, Justin, Mitchell, Emily, Lotz, Gregor P., Sapp, Ellen, Ng, Cheping, DiFiglia, Marian, Thompson, Leslie M., Muchowski, Paul J.

“…Huntington disease (HD) is caused by an expansion of more than 35–40 polyglutamine (polyQ) repeats in the huntingtin (htt) protein, resulting in accumulation…”
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The role of amyloidogenic protein oligomerization in neurodegenerative disease by Lotz, Gregor P., Legleiter, Justin

“…A common pathological hallmark in many neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, is the…”
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Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models by Sontag, Emily Mitchell, Lotz, Gregor P, Agrawal, Namita, Tran, Andrew, Aron, Rebecca, Yang, Guocheng, Necula, Mihaela, Lau, Alice, Finkbeiner, Steven, Glabe, Charles, Marsh, J Lawrence, Muchowski, Paul J, Thompson, Leslie M

“…Huntington's disease (HD) is a devastating neurodegenerative disorder with no disease-modifying treatments available. The disease is caused by expansion of a…”
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Characterization of anti-drug antibody responses to the T-cell engaging bispecific antibody cibisatamab to understand the impact on exposure by Lotz, Gregor P, Lutz, Achim, Martin-Facklam, Meret, Hansbauer, Andre, Schick, Eginhard, Moessner, Ekkehard, Antony, Michael, Stuchly, Thomas, Viert, Maria, Hosse, Ralf J, Freimoser-Grundschober, Anne, Klein, Christian, Schäfer, Martin, Ritter, Mirko, Stubenrauch, Kay-Gunnar

“…An appropriately designed pharmacokinetic (PK) assay that is sensitive for anti-drug antibody (ADA) impact on relevant exposure is an alternative strategy to…”
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Identifying polyglutamine protein species in situ that best predict neurodegeneration by Miller, Jason, Arrasate, Montserrat, Brooks, Elizabeth, Libeu, Clare Peters, Legleiter, Justin, Hatters, Danny, Curtis, Jessica, Cheung, Kenneth, Krishnan, Preethi, Mitra, Siddhartha, Widjaja, Kartika, Shaby, Benjamin A, Lotz, Gregor P, Newhouse, Yvonne, Mitchell, Emily J, Osmand, Alex, Gray, Michelle, Thulasiramin, Vanitha, Saudou, Frédéric, Segal, Mark, Yang, X William, Masliah, Eliezer, Thompson, Leslie M, Muchowski, Paul J, Weisgraber, Karl H, Finkbeiner, Steven

“…Conformation-specific antibodies and longitudinal tracking of individual neurons in situ identifies a toxic monomer species linked to Huntington's disease…”
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Proceedings of the 14th European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals by Tourdot, Sophie, Baltrunkonis, Daniel, Denies, Sofie, Devanarayan, Viswanath, Grudzinska-Goebel, Joanna, Kromminga, Arno, Lotz, Gregor P, Malherbe, Laurent, Michaut, Lydia, Weldingh, Karin N, Pedras-Vasconcelos, Joao A, Salazar-Fontana, Laura I, Spindeldreher, Sebastian, Sauna, Zuben, Snoeck, Veerle, Verthelyi, Daniela, Kramer, Daniel

“…Biologics have revolutionized disease management in many therapeutic areas by addressing unmet medical needs and overcoming resistance to standard-of-care…”
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Novel one-step immunoassays to quantify α-synuclein: applications for biomarker development and high-throughput screening by Bidinosti, Michael, Shimshek, Derya R, Mollenhauer, Brit, Marcellin, David, Schweizer, Tatjana, Lotz, Gregor P, Schlossmacher, Michael G, Weiss, Andreas

“…Familial Parkinson disease (PD) can result from α-synuclein gene multiplication, implicating the reduction of neuronal α-synuclein as a therapeutic target…”
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Monoclonal Antibodies Recognize Distinct Conformational Epitopes Formed by Polyglutamine in a Mutant Huntingtin Fragment by Legleiter, Justin, Lotz, Gregor P., Miller, Jason, Ko, Jan, Ng, Cheping, Williams, Geneva L., Finkbeiner, Steve, Patterson, Paul H., Muchowski, Paul J.

“…Huntington disease (HD) is a neurodegenerative disorder caused by an expansion of a polyglutamine (polyQ) domain in the N-terminal region of huntingtin (htt)…”
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Enhanced immunogenic potential of cancer immunotherapy antibodies in human IgG1 transgenic mice by Egli, Jerome, Heiler, Stefan, Weber, Felix, Steiner, Guido, Schwandt, Timo, Bray-French, Katharine, Klein, Christian, Fenn, Sebastian, Lotz, Gregor P, Opolka-Hoffmann, Eugenia, Kraft, Thomas E, Petersen, Laetitia, Moser, Rebecca, DeGeer, Jonathan, Siegel, Michel, Finke, Daniela, Bessa, Juliana, Iglesias, Antonio

“…ADA Anti-Drug Antibodies; BCR B Cell Receptor; BId Idiotype-specific B Cell; BiTE Bispecific T cell Engager; BMC Bone Marrow Chimeric Mice; BSA Bovine Serum…”
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When to Extend Monitoring of Anti-drug Antibodies for High-risk Biotherapeutics in Clinical Trials: an Opinion from the European Immunogenicity Platform by Lotz, Gregor P., Benstein, Karin, Bloem, Karien, Buddiger, Harm, Calonder, Claudio, Elm, Stefanie, Fernandez, Elena, Goodman, Joanne, Gorovits, Boris, Grudzinska-Goebel, Joanna, Janssen, Melody, Jawa, Vibha, Kramer, Daniel, Luo, Linlin, Malisauskas, Mantas, Michaut, Lydia, Schäfer, Martin, Spindeldreher, Sebastian, Ullmann, Martin, Nana Weldingh, Karin, Kromminga, Arno, Snoeck, Veerle

“…The determination of a tailored anti-drug antibody (ADA) testing strategy is based on the immunogenicity risk assessment to allow a correlation of ADAs with…”
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Hsp70 and Hsp40 Functionally Interact with Soluble Mutant Huntingtin Oligomers in a Classic ATP-dependent Reaction Cycle by Lotz, Gregor P., Legleiter, Justin, Aron, Rebecca, Mitchell, Emily J., Huang, Shao-Yi, Ng, Cheping, Glabe, Charles, Thompson, Leslie M., Muchowski, Paul J.

“…Inclusion bodies of aggregated mutant huntingtin (htt) fragments are a neuropathological hallmark of Huntington disease (HD). The molecular chaperones Hsp70…”
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2021 White Paper on Recent Issues in Bioanalysis: TAb/NAb, Viral Vector CDx, Shedding Assays; CRISPR/Cas9 & CAR-T Immunogenicity; PCR & Vaccine Assay Performance; ADA Assay Comparability & Cut Point Appropriateness by Loo, Lina, Harris, Shannon, Milton, Mark, Meena, Lembke, Wibke, Berisha, Flora, Bertholet, Sylvie, Dessy, Francis, Dodge, Robert, Fang, Xiaodong, Fiscella, Michele, Garofolo, Fabio, Gorovits, Boris, Gupta, Soumi, Jawa, Vibha, Ishii-Watabe, Akiko, Long, Brian, Lu, Yanmei, Mack, Timothy, McGuire, Kristina, Nolan, Katrina, Pan, Luying, Potthoff, Bernd, Purushothama, Shobha, Smith, Dean, Solstad, Therese, Sonderegger, Ivo, Taddeo, Frank, Tangri, Shabnam, Wagner, Leslie, Wu, Bonnie, Xu, Yuanxin, Kirshner, Susan, Verthelyi, Daniela, Yan, Haoheng, Maxfield, Kimberly, Pedras-Vasconcelos, Joao, Abhari, Mohsen Rajabi, Gupta, Swati, Wu, Yuling, Rajadhyaksha, Manoj, Andisik, Matthew, Baltrukonis, Daniel, Cherry, Elana, Cludts, Isabelle, Gunn, George, Millner, Anders Holm, Jordan, Gregor, Kar, Sumit, Kubiak, Robert, Lotz, Gregor P, Palmer, Rachel, Peng, Kun, Poetzl, Johann, Richards, Susan, Savoie, Natasha, Staack, Roland F, Stubenrauch, Kay, Wadhwa, Meenu, Waxenecker, Günter, Yang, Tong-Yuan, Zhang, Lucia

“…The 15th edition of the Workshop on Recent Issues in Bioanalysis (15th WRIB) was held on 27 September to 1 October 2021. Even with a last-minute move from…”
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Opportunities and Challenges for Molecular Chaperone Modulation to Treat Protein-Conformational Brain Diseases by van der Putten, Herman, Lotz, Gregor P.

“…A common pathological hallmark of protein-conformational brain diseases is the formation of disease-specific protein aggregates. In Alzheimer’s disease, these…”
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Loss of Hsp70 Exacerbates Pathogenesis But Not Levels of Fibrillar Aggregates in a Mouse Model of Huntington's Disease by Wacker, Jennifer L, Huang, Shao-Yi, Steele, Andrew D, Aron, Rebecca, Lotz, Gregor P, Nguyen, QuangVu, Giorgini, Flaviano, Roberson, Erik D, Lindquist, Susan, Masliah, Eliezer, Muchowski, Paul J

“…Endogenous protein quality control machinery has long been suspected of influencing the onset and progression of neurodegenerative diseases characterized by…”
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Fragments of HdhQ150 mutant huntingtin form a soluble oligomer pool that declines with aggregate deposition upon aging by Marcellin, David, Abramowski, Dorothee, Young, Douglas, Richter, Jens, Weiss, Andreas, Marcel, Audrey, Maassen, Julia, Kauffmann, Muriel, Bibel, Miriam, Shimshek, Derya R, Faull, Richard L M, Bates, Gillian P, Kuhn, Rainer R, Van der Putten, P Herman, Schmid, Peter, Lotz, Gregor P

“…Cleavage of the full-length mutant huntingtin (mhtt) protein into smaller, soluble aggregation-prone mhtt fragments appears to be a key process in the…”
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Aha1 Binds to the Middle Domain of Hsp90, Contributes to Client Protein Activation, and Stimulates the ATPase Activity of the Molecular Chaperone by Lotz, Gregor P., Lin, Hongying, Harst, Anja, Obermann, Wolfgang M.J.

“…The ATP-dependent molecular chaperone Hsp90 is an essential and abundant stress protein in the eukaryotic cytosol that cooperates with a cohort of…”
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European Immunogenicity Platform 11th Open Scientific Symposium on immunogenicity of biopharmaceuticals by Tourdot, Sophie, Quaglia, Carolina B, Chamberlain, Paul, De Groot, Anne S, Dellas, Nikki, Guillemare, Eric, Kromminga, Arno, Lotz, Gregor P, Mingozzi, Federico, Piccoli, Luca, Pine, Samuel, Richards, Susan, Waxenecker, Günter, Kramer, Daniel

“…Given the expanding number of complex therapeutic protein drugs and advanced therapy medicinal products that are being developed, improving our ability to…”
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novel HSP90 chaperone complex regulates intracellular vesicle transport by Lotz, Gregor P, Brychzy, Alexander, Heinz, Stefan, Obermann, Wolfgang M.J

“…Heat shock protein 90 (HSP90) is considered a specialized molecular chaperone that controls the folding of cell-regulatory proteins such as steroid receptors…”
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Immuno-based detection assays to quantify distinct mutant huntingtin conformations in biological samples by Lotz, Gregor P, Weiss, Andreas

“…A pathological hallmark of many protein-misfolding diseases is the formation of insoluble aggregates. Quantitative methods are needed to better resolve and…”
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Identifying polyglutamine protein species in situ that best predict neurodegeneration by Miller, Jason, Arrasate, Montserrat, Brooks, Elizabeth, Libeu, Clare Peters, Legleiter, Justin, Hatters, Danny, Curtis, Jessica, Cheung, Kenneth, Krishnan, Preethi, Mitra, Siddhartha, Widjaja, Kartika, Shaby, Benjamin A, Lotz, Gregor P, Newhouse, Yvonne, Mitchell, Emily J, Osmand, Alex, Gray, Michelle, Thulasiramin, Vanitha, Saudou, Frédéric, Segal, Mark, Yang, X William, Masliah, Eliezer, Thompson, Leslie M, Muchowski, Paul J, Weisgraber, Karl H, Finkbeiner, Steven

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