Search Results - "Lotta, Luca Andrea"

A novel CD46 mutation in a patient with microangiopathy clinically resembling thrombotic thrombocytopenic purpura and normal ADAMTS13 activity by Rossio, Raffaella, Lotta, Luca Andrea, Pontiggia, Silvia, Borsa, Nicolò Ghiringhelli, Garagiola, Isabella, Ardissino, Gianluigi, Mikovic, Danijela, Cugno, Massimo, Peyvandi, Flora

Get full text

Genome-wide association studies in atherothrombosis by Lotta, Luca Andrea

“…Abstract Atherothrombotic diseases are complex diseases, arising from the interaction between several genetic and environmental factors. Until recently, the…”
Get full text

Translating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction by Sun, Jiangming, Wang, Yunpeng, Folkersen, Lasse, Borné, Yan, Amlien, Inge, Buil, Alfonso, Orho-Melander, Marju, Børglum, Anders D., Hougaard, David M., Melander, Olle, Engström, Gunnar, Werge, Thomas, Lage, Kasper

“…A promise of genomics in precision medicine is to provide individualized genetic risk predictions. Polygenic risk scores (PRS), computed by aggregating effects…”
Get full text

FRETS-VWF73 rather than CBA assay reflects ADAMTS13 proteolytic activity in acquired thrombotic thrombocytopenic purpura patients by Mancini, I, Valsecchi, C, Lotta, L A, Deforche, L, Pontiggia, S, Bajetta, M, Palla, R, Vanhoorelbeke, K, Peyvandi, F

“…Collagen-binding activity (CBA) and FRETS-VWF73 assays are widely adopted methods for the measurement of the plasmatic activity of ADAMTS13, the von Willebrand…”
Get more information

The Role of ADAMTS13-Specific Circulating Immune Complexes in Prediction of Recurrence of Acquired Thrombotic Thrombocytopenic Purpura by Ferrari, Barbara, Valsecchi, Carla, Pontiggia, Silvia, Mancini, Ilaria, Lotta, Luca Andrea, Mikovic, Danijela, Meloni, Giovanna, Peyvandi, Flora

“…Introduction. Acquired thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy due to the development of autoantibodies against the…”
Get full text

Different clinical severity of first episodes and recurrences of thrombotic thrombocytopenic purpura by Lotta, Luca A., Mariani, Mariagabriella, Consonni, Dario, Mancini, Ilaria, Palla, Roberta, Maino, Alberto, Vucelic, Dragica, Pizzuti, Michele, Mannucci, Pier M., Peyvandi, Flora

“…Summary The clinical course of thrombotic thrombocytopenic purpura (TTP) is characterized by recurrent disease episodes in up to 50% of cases. The clinical…”
Get full text

Complications of Pregnancy in Women with Thrombotic Thrombocytopenic Purpura by Ferrari, Barbara, Lotta, Luca Andrea, Artoni, Andrea, Pontiggia, Silvia, Trisolini, Silvia, Mikovic, Danijela, Rosendaal, Frits R., Peyvandi, Flora

“…Abstract 3322 Thrombotic Thrombocytopenic Purpura (TTP) occurring in association with pregnancy or puerperium accounts for 12–25% of all TTP acute episodes…”
Get full text

Association of a single nucleotide polymorphism of the NPR3 gene promoter with early onset ischemic stroke in an Italian cohort by Rubattu, Speranza, Giusti, Betti, Lotta, Luca Andrea, Peyvandi, Flora, Cotugno, Maria, Stanzione, Rosita, Marchitti, Simona, Palombella, Anna Maria, Di Castro, Sara, Rasura, Maurizia, Mannucci, Pier Mannuccio, Volpe, Massimo

“…Abstract Background NPR3 , located on human chromosome 5 ( 5p14–p13 ), encodes the natriuretic peptide receptor type C (NPR-C) that is mainly known as the…”
Get full text

B and T lymphocytes in acquired Thrombotic Thrombocytopenic Purpura during disease remission by Mariani, Mariagabriella, Cairo, Andrea, Palla, Roberta, Lotta, Luca Andrea, Consonni, Dario, Rovati, Andrea, Trisolini, Silvia, Peyvandi, Flora

Get full text

Elevated Hematocrit Concentration and the Risk of Mortality and Vascular Events in Patients Undergoing Major Surgery by Musallam, Khaled M, Porter, John B, Soweid, Assaad, Hoballah, Jamal J, Sfeir, Pierre M, Khalife, Mohamed, Zeineldine, Salah, Tamim, Hani M, Richards, Toby, Lotta, Luca Andrea, Peyvandi, Flora, Jamali, Faek R

“…Abstract 2088 Preoperative anemia is associated with adverse outcomes after major surgery. This study evaluates the effect of elevated hematocrit concentration…”
Get full text

Rare Coding Single Nucleotide Variants of ADAMTS13 Are Associated with Deep Vein Thrombosis in a Next-Generation Sequencing Association Study by Lotta, Luca Andrea, Tuana, Giacomo, Yu, Jin, Martinelli, Ida, Wang, Mark, Yu, Fuli, Passamonti, Serena Maria, Pappalardo, Emanuela, IV, Walker Hale, Muzny, Donna M., Rosendaal, Frits R., Gibbs, Richard A, Peyvandi, Flora

“…Abstract 107 The considerable genetic predisposition to deep vein thrombosis (DVT) is only partially accounted for by known genetic risk variants. Genome-wide…”
Get full text

The Role of B and T Lymphocytes in Recurrent Acquired Thrombotic Thrombocytopenic Purpura by Mariani, Mariagabriella, Cairo, Andrea, Palla, Roberta, Lotta, Luca Andrea, Rovati, Andrea, Trisolini, Silvia Maria, Peyvandi, Flora

“…Abstract 3521 Poster Board III-458 Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disease characterized by thrombocytopenia,…”
Get full text

Identification of DEEP Vein Thrombosis GENETIC RISK Variants by NEXT GENERATION Sequencing of Hemostatic Genes by Lotta, Luca Andrea, Wang, Mark, Yu, Jin, Yu, Fuli, Martinelli, Ida, Passamonti, Serena, Pappalardo, Emanuela, Menegatti, Marzia, Lewis, Lora L, Hale, Walker, Muzny, Donna M, Mannucci, Pier Mannuccio, Gibbs, Richard A, Peyvandi, Flora

“…Abstract 710 Next-generation DNA sequencing is opening new avenues for genetic association studies in complex diseases that, like deep vein thrombosis (DVT),…”
Get full text

Genotyp-Phenotype Correlation in Congenital ADAMTS13 Deficient Patients by Lotta, Luca Andrea, Garagiola, Isabella, Cairo, Andrea, Klaassen, Robert, Metin, Ayse, Gurgey, Aytemiz, Peyvandi, Flora

“…BACKGROUND: Thrombotic thrombocytopenic purpura (TTP) is characterized by thrombocytopenia and microangiopathic hemolytic anemia. Congenital TTP is associated…”
Get full text

A novel CD46 mutation in a patient with microangiopathy clinically resembling thrombotic thrombocytopenic purpura and normal ADAMTS13 activity by Rossio, Raffaella, Lotta, Luca Andrea, Pontiggia, Silvia, Borsa, Nicolò Ghiringhelli, Garagiola, Isabella, Ardissino, Gianluigi, Mikovic, Danijela, Cugno, Massimo, Peyvandi, Flora

Get full text