Search Results - "Lott, T."

Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology by Head, Elizabeth, Lott, Ira T, Wilcock, Donna M, Lemere, Cynthia A

“…Chromosome 21, triplicated in Down Syndrome, contains several genes that are thought to play a critical role in the development of AD neuropathology. The…”
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Cognitive deficits and associated neurological complications in individuals with Down's syndrome by Lott, Ira T, MD, Dierssen, Mara, MD

“…Summary Improvements in medical interventions for people with Down's syndrome have led to a substantial increase in their longevity. Diagnosis and treatment of…”
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Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer's Disease: The Role of APP by Doran, Eric, Keator, David, Head, Elizabeth, Phelan, Michael J, Kim, Ron, Totoiu, Minodora, Barrio, Jorge R, Small, Gary W, Potkin, Steven G, Lott, Ira T

“…Overexpression of the amyloid precursor protein (APP) gene on chromosome 21 in Down syndrome (DS) has been linked to increased brain amyloid levels and…”
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Shelf-life storage temperature has a considerably larger effect than high-temperature, short-time pasteurization temperature on the growth of spore-forming bacteria in fluid milk by Lott, T.T., Wiedmann, M., Martin, N.H.

“…In the absence of postpasteurization contamination, psychrotolerant, aerobic spore-forming bacteria that survive high-temperature, short-time (HTST)…”
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Predicting the pathogenicity of novel variants in mitochondrial tRNA with MitoTIP by Sonney, Sanjay, Leipzig, Jeremy, Lott, Marie T, Zhang, Shiping, Procaccio, Vincent, Wallace, Douglas C, Sondheimer, Neal

“…Novel or rare variants in mitochondrial tRNA sequences may be observed after mitochondrial DNA analysis. Determining whether these variants are pathogenic is…”
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Specifications of the ACMG/AMP standards and guidelines for mitochondrial DNA variant interpretation by McCormick, Elizabeth M., Lott, Marie T., Dulik, Matthew C., Shen, Lishuang, Attimonelli, Marcella, Vitale, Ornella, Karaa, Amel, Bai, Renkui, Pineda‐Alvarez, Daniel E., Singh, Larry N., Stanley, Christine M., Wong, Stacey, Bhardwaj, Anshu, Merkurjev, Daria, Mao, Rong, Sondheimer, Neal, Zhang, Shiping, Procaccio, Vincent, Wallace, Douglas C., Gai, Xiaowu, Falk, Marni J.

“…Mitochondrial DNA (mtDNA) variant pathogenicity interpretation has special considerations given unique features of the mtDNA genome, including maternal…”
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mtDNA Variation and Analysis Using Mitomap and Mitomaster by Lott, Marie T, Leipzig, Jeremy N, Derbeneva, Olga, Xie, H Michael, Chalkia, Dimitra, Sarmady, Mahdi, Procaccio, Vincent, Wallace, Douglas C

“…The Mitomap database of human mitochondrial DNA (mtDNA) information has been an important compilation of mtDNA variation for researchers, clinicians and…”
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Use of an anti-viral drug, Ribavirin, as an anti-glioblastoma therapeutic by Volpin, F, Casaos, J, Sesen, J, Mangraviti, A, Choi, J, Gorelick, N, Frikeche, J, Lott, T, Felder, R, Scotland, S J, Eisinger-Mathason, T S K, Brem, H, Tyler, B, Skuli, N

“…The median survival for glioblastoma patients is ~15 months despite aggressive surgery and radio-chemotherapy approaches. Thus, developing new therapeutics is…”
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APOGEE 2: multi-layer machine-learning model for the interpretable prediction of mitochondrial missense variants by Bianco, Salvatore Daniele, Parca, Luca, Petrizzelli, Francesco, Biagini, Tommaso, Giovannetti, Agnese, Liorni, Niccolò, Napoli, Alessandro, Carella, Massimo, Procaccio, Vincent, Lott, Marie T., Zhang, Shiping, Vescovi, Angelo Luigi, Wallace, Douglas C., Caputo, Viviana, Mazza, Tommaso

“…Mitochondrial dysfunction has pleiotropic effects and is frequently caused by mitochondrial DNA mutations. However, factors such as significant variability in…”
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Gram-negative postpasteurization contamination patterns of single-serve fluid milk produced in 4 different processing facilities by Lott, T.T., Stelick, A.N., Wiedmann, M., Martin, N.H.

“…An analysis of historic data on high temperature, short time (HTST) fluid milk quality showed higher total bacterial counts and lower sensory defect judging…”
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Intensive Environmental Sampling and Whole Genome Sequence-based Characterization of Listeria in Small- and Medium-sized Dairy Facilities Reveal Opportunities for Simplified and Size-appropriate Environmental Monitoring Strategies by Bolten, Samantha, Lott, Timothy T., Ralyea, Robert D., Gianforte, Anika, Trmcic, Aljosa, Orsi, Renato H., Martin, Nicole H., Wiedmann, Martin

“…•A total of 13% of environmental sponge samples tested positive for Listeria.•Collecting sponges pre- vs. mid-operation yielded similar Listeria percent…”
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Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome by Hamlett, Eric D, Goetzl, Edward J, Ledreux, Aurélie, Vasilevko, Vitaly, Boger, Heather A, LaRosa, Angela, Clark, David, Carroll, Steven L, Carmona-Iragui, María, Fortea, Juan, Mufson, Elliott J, Sabbagh, Marwan, Mohammed, Abdul H, Hartley, Dean, Doran, Eric, Lott, Ira T, Granholm, Ann-Charlotte

“…Abstract Introduction Individuals with Down syndrome (DS) exhibit Alzheimer's disease (AD) neuropathology and dementia early in life. Blood biomarkers of AD…”
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Down syndrome: from understanding the neurobiology to therapy by Gardiner, Katheleen, Herault, Yann, Lott, Ira T, Antonarakis, Stylianos E, Reeves, Roger H, Dierssen, Mara

“…Down syndrome (DS) is the most common example of a neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy…”
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Alzheimer disease and Down syndrome: factors in pathogenesis by Lott, Ira T., Head, Elizabeth

“…There is evidence to suggest that certain shared features exist in the pathogenesis of vascular disease and Alzheimer disease (AD) in the general population…”
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Development and deployment of a supply-chain digital tool to predict fluid-milk spoilage due to psychrotolerant sporeformers by Qian, C, Murphy, S I, Lott, T T, Martin, N H, Wiedmann, M

“…Psychrotolerant sporeformers pose a challenge to maintaining fluid milk quality. Dynamic temperature changes along the supply chain can favor the germination…”
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Microbacterium represents an emerging microorganism of concern in microfiltered extended shelf-life milk products by Lott, T T, Martin, N H, Dumpler, J, Wiedmann, M, Moraru, C I

“…Growing interest in the manufacture of extended shelf-life (ESL) milk, which is typically achieved by a high-temperature treatment called ultra-pasteurization…”
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enhanced MITOMAP with a global mtDNA mutational phylogeny by Ruiz-Pesini, Eduardo, Lott, Marie T, Procaccio, Vincent, Poole, Jason C, Brandon, Marty C, Mishmar, Dan, Yi, Christina, Kreuziger, James, Baldi, Pierre, Wallace, Douglas C

“…The MITOMAP (http://www.mitomap.org) data system for the human mitochondrial genome has been greatly enhanced by the addition of a navigable mutational…”
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Research attitudes in families of individuals with Down syndrome: importance for clinical trials by Lott, Ira T, Kirby, Katharine A, Doran, Eric, Grill, Joshua D

“…Individuals with Down syndrome (DS) are increasingly eligible for clinical trial intervention, particularly for the treatment or prevention of Alzheimer…”
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Dementia in Down syndrome: unique insights for Alzheimer disease research by Lott, Ira T., Head, Elizabeth

“…Virtually all adults with Down syndrome (DS) show the neuropathological changes of Alzheimer disease (AD) by the age of 40 years. This association is partially…”
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Down syndrome and dementia: A randomized, controlled trial of antioxidant supplementation by Lott, Ira T., Doran, Eric, Nguyen, Vinh Q., Tournay, Anne, Head, Elizabeth, Gillen, Daniel L.

“…Individuals with Down syndrome over age 40 years are at risk for developing dementia of the Alzheimer type and have evidence for chronic oxidative stress…”
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