Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in young but not in old rats

We evaluated the effect of exposure to constant light started at the age of 1 month and at the age of 14 months on the survival, life span, tumorigenesis and age-related dynamics of antioxidant enzymes activity in various organs in comparison to the rats maintained at the standard (12:12 light/dark)...

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Bibliographic Details
Published in:	Aging (Albany, NY.) Vol. 2; no. 2; pp. 82 - 92
Main Authors:	Vinogradova, Irina A, Anisimov, Vladimir N, Bukalev, Andrey V, Ilyukha, Viktor A, Khizhkin, Evgeniy A, Lotosh, Tatiana A, Semenchenko, Anna V, Zabezhinski, Mark A
Format:	Journal Article
Language:	English
Published:	United States Impact Journals LLC 20-03-2010
Subjects:	Age Factors Aging - radiation effects Animals Catalase - metabolism Circadian Rhythm - radiation effects Female Light - adverse effects Longevity - radiation effects Male Neoplasms - etiology Oxidative Stress - radiation effects Photoperiod Pineal Gland - radiation effects Rats Superoxide Dismutase - metabolism
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Summary:	We evaluated the effect of exposure to constant light started at the age of 1 month and at the age of 14 months on the survival, life span, tumorigenesis and age-related dynamics of antioxidant enzymes activity in various organs in comparison to the rats maintained at the standard (12:12 light/dark) light/dark regimen. We found that exposure to constant light started at the age of 1 month accelerated spontaneous tumorigenesis and shortened life span both in male and female rats as compared to the standard regimen. At the same time, the exposure to constant light started at the age of 14 months failed to influence survival of male and female rats. While delaying tumors in males, constant light accelerated tumors in females. We conclude that circadian disruption induced by light-at-night started at the age of 1 month accelerates aging and promotes tumorigenesis in rats, however failed affect survival when started at the age of 14 months.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1945-4589 1945-4589
DOI:	10.18632/aging.100120