Search Results - "Lotjonen, J."

Follow-up of [11C]PIB uptake and brain volume in patients with Alzheimer disease and controls by SCHEININ, N. M, AALTO, S, RINNE, J. O, KOIKKALAINEN, J, LÖTJÖNEN, J, KARRASCH, M, KEMPPAINEN, N, VIITANEN, M, NAGREN, K, HELIN, S, SCHEININ, M

“…In Alzheimer disease (AD), the accumulation pattern of beta-amyloid over time and its relationship with dementia severity are unclear. We investigated the…”
Get full text

Global Burden of Small Vessel Disease–Related Brain Changes on MRI Predicts Cognitive and Functional Decline by Jokinen, Hanna, Koikkalainen, Juha, Laakso, Hanna M., Melkas, Susanna, Nieminen, Tuomas, Brander, Antti, Korvenoja, Antti, Rueckert, Daniel, Barkhof, Frederik, Scheltens, Philip, Schmidt, Reinhold, Fazekas, Franz, Madureira, Sofia, Verdelho, Ana, Wallin, Anders, Wahlund, Lars-Olof, Waldemar, Gunhild, Chabriat, Hugues, Hennerici, Michael, O’Brien, John, Inzitari, Domenico, Lötjönen, Jyrki, Pantoni, Leonardo, Erkinjuntti, Timo

“…BACKGROUND AND PURPOSE—Cerebral small vessel disease is characterized by a wide range of focal and global brain changes. We used a magnetic resonance imaging…”
Get full text

Metabolome in progression to Alzheimer's disease by Orešič, M, Hyötyläinen, T, Herukka, S-K, Sysi-Aho, M, Mattila, I, Seppänan-Laakso, T, Julkunen, V, Gopalacharyulu, P V, Hallikainen, M, Koikkalainen, J, Kivipelto, M, Helisalmi, S, Lötjönen, J, Soininen, H

“…Mild cognitive impairment (MCI) is considered as a transition phase between normal aging and Alzheimer's disease (AD). MCI confers an increased risk of…”
Get full text

Methods of Artificial Enlargement of the Training Set for Statistical Shape Models by Koikkalainen, J., Tolli, T., Lauerma, K., Antila, K., Mattila, E., Lilja, M., Lotjonen, J.

“…Due to the small size of training sets, statistical shape models often over-constrain the deformation in medical image segmentation. Hence, artificial…”
Get full text

Reconstruction of 3-D head geometry from digitized point sets: an evaluation study by Koikkalainen, J., Lotjonen, J.

“…In this paper, we evaluate different methods to estimate patient-specific scalp, skull, and brain surfaces from a set of digitized points from the target's…”
Get full text

Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models by Härmä, V, Knuuttila, M, Virtanen, J, Mirtti, T, Kohonen, P, Kovanen, P, Happonen, A, Kaewphan, S, Ahonen, I, Kallioniemi, O, Grafström, R, Lötjönen, J, Nees, M

“…Normal prostate and some malignant prostate cancer (PrCa) cell lines undergo acinar differentiation and form spheroids in three-dimensional (3-D) organotypic…”
Get full text

Reconstruction of 3-D geometry using 2-D profiles and a geometric prior model by Lotjonen, J., Magnin, I.E., Nenonen, J., Katila, T.

“…A method has been developed to reconstruct three-dimensional (3-D) surfaces from two-dimensional (2-D) projection data. It is used to produce individualized…”
Get full text

Statistical shape model of atria, ventricles and epicardium from short- and long-axis MR images by Lötjönen, J., Kivistö, S., Koikkalainen, J., Smutek, D., Lauerma, K.

“…We describe a new 3-D statistical shape model of the heart consisting of atria, ventricles and epicardium. The model was constructed by combining information…”
Get full text

Decreased Gray—White Matter Contrast of [11C]-PiB Uptake in Cognitively Unimpaired Subjects with Severe Obstructive Sleep Apnea by Ylä-Herttuala, S., Hakulinen, M., Poutiainen, P., Lötjönen, J., Könönen, M., Gröhn, H., Vanninen, R., Mussalo, H., Laitinen, T., Mervaala, Esa

“…Background Very recently, cognitively normal, middle-aged adults with severe obstructive sleep apnea (OSA) were shown to have regional cortical amyloid-β…”
Get full text

EEG spectral entropy, heart rate, photoplethysmography and motor responses to skin incision during sevoflurane anaesthesia by Seitsonen, E. R. J., Korhonen, I. K. J., Van Gils, M. J., Huiku, M., Lötjönen, J. M. P., Korttila, K. T., Yli-Hankala, A. M.

“…Background:  Analgesia is a part of balanced anaesthesia, but direct indicators of nociception do not exist. We examined the relationship between motor…”
Get full text

Robust whole-brain segmentation: Application to traumatic brain injury by Ledig, Christian, Heckemann, Rolf A., Hammers, Alexander, Lopez, Juan Carlos, Newcombe, Virginia F.J., Makropoulos, Antonios, Lötjönen, Jyrki, Menon, David K., Rueckert, Daniel

“…[Display omitted] •A robust and fully-automatic segmentation framework for MR brain scans is proposed.•A heterogeneous cohort of 125 scans of patients who had…”
Get full text

Application of the PredictAD decision support tool to a Danish cohort of patients with Alzheimer's disease and other dementias by Simonsen, A H, Mattila, J, Hejl, A M, Garde, E, van Gils, M, Thomsen, C, Lötjönen, J, Soininen, H, Waldemar, G

“…The diagnosis of Alzheimer's disease (AD) is based on an ever-increasing body of data and knowledge making it a complex task. The PredictAD tool integrates…”
Get more information

Change in CAIDE Dementia Risk Score and Neuroimaging Biomarkers During a 2-Year Multidomain Lifestyle Randomized Controlled Trial: Results of a Post-Hoc Subgroup Analysis by Stephen, Ruth, Ngandu, Tiia, Liu, Yawu, Peltonen, Markku, Antikainen, Riitta, Kemppainen, Nina, Laatikainen, Tiina, Lötjönen, Jyrki, Rinne, Juha, Strandberg, Timo, Tuomilehto, Jaakko, Vanninen, Ritva, Soininen, Hilkka, Kivipelto, Miia, Solomon, Alina

“…Abstract The CAIDE (Cardiovascular Risk Factors, Aging and Dementia) Risk Score is a validated tool estimating dementia risk. It was previously associated with…”
Get full text

Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) by Stephen, Ruth, Liu, Yawu, Ngandu, Tiia, Antikainen, Riitta, Hulkkonen, Juha, Koikkalainen, Juha, Kemppainen, Nina, Lötjönen, Jyrki, Levälahti, Esko, Parkkola, Riitta, Pippola, Pauliina, Rinne, Juha, Strandberg, Timo, Tuomilehto, Jaakko, Vanninen, Ritva, Kivipelto, Miia, Soininen, Hilkka, Solomon, Alina

“…The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) was a multicenter randomized controlled trial that reported…”
Get full text

Development of a Late-Life Dementia Prediction Index with Supervised Machine Learning in the Population-Based CAIDE Study by Pekkala, Timo, Hall, Anette, Lötjönen, Jyrki, Mattila, Jussi, Soininen, Hilkka, Ngandu, Tiia, Laatikainen, Tiina, Kivipelto, Miia, Solomon, Alina

“…This study aimed to develop a late-life dementia prediction model using a novel validated supervised machine learning method, the Disease State Index (DSI), in…”
Get more information

The effect of geometric and topologic differences in boundary element models on magnetocardiographic localization accuracy by Pesola, K., Lojtjonen, J., Nenonen, J., Magnin, I.E., Lauerma, K., Fenici, R., Katila, T.

“…This study was performed to evaluate the changes in magnetocardiographic (MCG) source localization results when the geometry and the topology of the volume…”
Get full text

Nonfluoroscopic Localization of an Amagnetic Stimulation Catheter by Multichannel Magnetocardiography by FENICI, RICCARDO, NENONEN, JUKKA, PESOLA, KATJA, KORHONEN, PETRI, LÖTJÖNEN, JYRKI, MÄKIJÄRVI, MARKKU, TOIVONEN, LAURI, POUTANEN, VELI-PEKKA, KETO, PEKKA, KATILA, TOIVO

“…This study was performed to: (1) evaluate the accuracy of noninvasive magnetocardiographic (MCG) localization of an amagnetic stimulation catheter; (2)…”
Get full text

75 Predict Alzheimer's disease tools for early diagnosis by Liu, Y, Mattila, J, Paajanen, T, Koikkalainen, J, vanGils, M, Herukka, S.-K, Waldemar, G, Lötjönen, J, Soininen, Hilkka

Get full text

Optimising disease state fingerprint for diagnosing frontotemporal lobar degeneration by Ruiz, M.Á. Munoz, Hall, A, Mattila, J, Koikkalainen, J, Herukka, S.-K, Husso, M, Hänninen, T, Vanninen, R, Liu, Y, Hallikainen, M, Lötjönen, J, Soininen, H, Hartikainen, P

Get full text

Prediction models for dementia and neuropathology in the oldest old: the Vantaa 85+ cohort study by Hall, Anette, Pekkala, Timo, Polvikoski, Tuomo, van Gils, Mark, Kivipelto, Miia, Lötjönen, Jyrki, Mattila, Jussi, Kero, Mia, Myllykangas, Liisa, Mäkelä, Mira, Oinas, Minna, Paetau, Anders, Soininen, Hilkka, Tanskanen, Maarit, Solomon, Alina

“…We developed multifactorial models for predicting incident dementia and brain pathology in the oldest old using the Vantaa 85+ cohort. We included participants…”
Get full text