Search Results - "Lothe, Ragnhild"

Biomarker-guided therapy for colorectal cancer: strength in complexity by Sveen, Anita, Kopetz, Scott, Lothe, Ragnhild A.

“…The number of molecularly stratified treatment options available to patients with colorectal cancer (CRC) is increasing, with a parallel rise in the use of…”
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CMScaller: an R package for consensus molecular subtyping of colorectal cancer pre-clinical models by Eide, Peter W., Bruun, Jarle, Lothe, Ragnhild A., Sveen, Anita

“…Colorectal cancers (CRCs) can be divided into four gene expression-based biologically distinct consensus molecular subtypes (CMS). This classification provides…”
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Portrait of the PI3K/AKT pathway in colorectal cancer by Danielsen, Stine Aske, Eide, Peter Wold, Nesbakken, Arild, Guren, Tormod, Leithe, Edward, Lothe, Ragnhild A.

“…PI3K/AKT signaling leads to reduced apoptosis, stimulates cell growth and increases proliferation. Under normal conditions, PI3K/AKT activation is tightly…”
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Combination therapies with HSP90 inhibitors against colorectal cancer by Kryeziu, Kushtrim, Bruun, Jarle, Guren, Tormod K., Sveen, Anita, Lothe, Ragnhild A.

“…Oncogene stability and homeostasis mediated by the HSP90 chaperone is a crucial protection trait of cancer cells. Therefore, HSP90 represents an attractive…”
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Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies by Berg, Kaja C G, Eide, Peter W, Eilertsen, Ina A, Johannessen, Bjarne, Bruun, Jarle, Danielsen, Stine A, Bjørnslett, Merete, Meza-Zepeda, Leonardo A, Eknæs, Mette, Lind, Guro E, Myklebost, Ola, Skotheim, Rolf I, Sveen, Anita, Lothe, Ragnhild A

“…Colorectal cancer (CRC) cell lines are widely used pre-clinical model systems. Comprehensive insights into their molecular characteristics may improve model…”
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Spatial analysis and CD25-expression identify regulatory T cells as predictors of a poor prognosis in colorectal cancer by Bergsland, Christian H., Jeanmougin, Marine, Moosavi, Seyed H., Svindland, Aud, Bruun, Jarle, Nesbakken, Arild, Sveen, Anita, Lothe, Ragnhild A.

“…Regulatory T cells (Tregs) are a heterogeneous cell population that can either suppress or stimulate immune responses. Tumor-infiltrating Tregs are associated…”
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Multifocal Primary Prostate Cancer Exhibits High Degree of Genomic Heterogeneity by Løvf, Marthe, Zhao, Sen, Axcrona, Ulrika, Johannessen, Bjarne, Bakken, Anne Cathrine, Carm, Kristina Totland, Hoff, Andreas M., Myklebost, Ola, Meza-Zepeda, Leonardo A., Lie, A. Kathrine, Axcrona, Karol, Lothe, Ragnhild A., Skotheim, Rolf I.

“…Most primary prostate cancers are multifocal with individual tumors harboring different aggressiveness; however, the genomic heterogeneity among these tumors…”
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'High proliferative cribriform prostate cancer' defines a patient subgroup with an inferior prognosis by Bogaard, Mari, Skotheim, Rolf I, Maltau, Aase V, Kidd, Susanne G, Lothe, Ragnhild A, Axcrona, Karol, Axcrona, Ulrika

“…A cribriform pattern, reactive stroma (RS), PTEN, Ki67 and ERG are promising prognostic biomarkers in primary prostate cancer (PCa). We aim to determine the…”
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Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies by Sveen, Anita, Bruun, Jarle, Eide, Peter W, Eilertsen, Ina A, Ramirez, Lorena, Murumägi, Astrid, Arjama, Mariliina, Danielsen, Stine A, Kryeziu, Kushtrim, Elez, Elena, Tabernero, Josep, Guinney, Justin, Palmer, Hector G, Nesbakken, Arild, Kallioniemi, Olli, Dienstmann, Rodrigo, Lothe, Ragnhild A

“…Response to standard oncologic treatment is limited in colorectal cancer. The gene expression-based consensus molecular subtypes (CMS) provide a new paradigm…”
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GRIN3A: A biomarker associated with a cribriform pattern and poor prognosis in prostate cancer by Bogaard, Mari, Strømme, Jonas M., Kidd, Susanne G., Johannessen, Bjarne, Bakken, Anne C., Lothe, Ragnhild A., Axcrona, Karol, Skotheim, Rolf I., Axcrona, Ulrika

“…Prostate cancer with a cribriform pattern, including invasive cribriform carcinoma (ICC) and/or intraductal carcinoma (IDC) is associated with a poor…”
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Patient-Derived Organoids from Multiple Colorectal Cancer Liver Metastases Reveal Moderate Intra-patient Pharmacotranscriptomic Heterogeneity by Bruun, Jarle, Kryeziu, Kushtrim, Eide, Peter W, Moosavi, Seyed H, Eilertsen, Ina A, Langerud, Jonas, Røsok, Bård, Totland, Max Z, Brunsell, Tuva H, Pellinen, Teijo, Saarela, Jani, Bergsland, Christian H, Palmer, Hector G, Brudvik, Kristoffer W, Guren, Tormod, Dienstmann, Rodrigo, Guren, Marianne G, Nesbakken, Arild, Bjørnbeth, Bjørn Atle, Sveen, Anita, Lothe, Ragnhild A

“…Molecular tumor heterogeneity may have important implications for the efficacy of targeted therapies in metastatic cancers. Inter-metastatic heterogeneity of…”
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Co-occurring mutations identify prognostic subgroups of microsatellite stable colorectal cancer by Nunes, Luís, Stenersen, Jakob Mørkved, Kryeziu, Kushtrim, Sjöblom, Tobias, Glimelius, Bengt, Lothe, Ragnhild A., Sveen, Anita

“…Co-occurring mutations in pairs of genes can pinpoint clinically relevant subgroups of cancer. Most colorectal cancers (CRCs) are microsatellite stable (MSS)…”
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Somatic mutations reveal complex metastatic seeding from multifocal primary prostate cancer by Carm, Kristina T., Johannessen, Bjarne, Bogaard, Mari, Bakken, Anne Cathrine, Maltau, Aase V., Hoff, Andreas M., Axcrona, Ulrika, Axcrona, Karol, Lothe, Ragnhild A., Skotheim, Rolf I.

“…Primary prostate cancer shows a striking intraorgan molecular heterogeneity, with multiple spatially separated malignant foci in the majority of patients…”
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Long noncoding RNA MIR31HG is a bona fide prognostic marker with colorectal cancer cell‐intrinsic properties by Eide, Peter W., Eilertsen, Ina A., Sveen, Anita, Lothe, Ragnhild A.

“…Elevated miR‐31 expression is associated with poor outcome in colorectal cancer (CRC). Whether the prognostic information is independent of known molecular…”
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Intra-patient Inter-metastatic Genetic Heterogeneity in Colorectal Cancer as a Key Determinant of Survival after Curative Liver Resection by Sveen, Anita, Løes, Inger Marie, Alagaratnam, Sharmini, Nilsen, Gro, Høland, Maren, Lingjærde, Ole Christian, Sorbye, Halfdan, Berg, Kaja Christine Graue, Horn, Arild, Angelsen, Jon-Helge, Knappskog, Stian, Lønning, Per Eystein, Lothe, Ragnhild A

“…Chromosomal instability is a well-defined hallmark of tumor aggressiveness and metastatic progression in colorectal cancer. The magnitude of genetic…”
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MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer by Cekaite, Lina, Eide, Peter W, Lind, Guro E, Skotheim, Rolf I, Lothe, Ragnhild A

“…Gene expression is in part regulated by microRNAs (miRNAs). This review summarizes the current knowledge of miRNAs in colorectal cancer (CRC); their role as…”
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Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas by Lind, Guro E, Danielsen, Stine A, Ahlquist, Terje, Merok, Marianne A, Andresen, Kim, Skotheim, Rolf I, Hektoen, Merete, Rognum, Torleiv O, Meling, Gunn I, Hoff, Geir, Bretthauer, Michael, Thiis-Evensen, Espen, Nesbakken, Arild, Lothe, Ragnhild A

“…The presence of cancer-specific DNA methylation patterns in epithelial colorectal cells in human feces provides the prospect of a simple, non-invasive…”
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Oncogenicity of the Developmental Transcription Factor Sox9 by MATHEU, Ander, COLLADO, Manuel, SKOTHEIM, Rolf I, LOTHE, Ragnhild A, DE MUNAIN, Adolfo López, BRISCOE, James, SERRANO, Manuel, LOVELL-BADGE, Robin, WISE, Clare, MANTEROLA, Lorea, CEKAITE, Lina, TYE, Angela J, CANAMERO, Marta, BUJANDA, Luis, SCHEDL, Andreas, CHEAH, Kathryn S. E

“…SOX9 [sex-determining region Y (SRY)-box 9 protein], a high mobility group box transcription factor, plays critical roles during embryogenesis and its activity…”
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Four DNA methylation biomarkers in biliary brush samples accurately identify the presence of cholangiocarcinoma by Andresen, Kim, Boberg, Kirsten Muri, Vedeld, Hege Marie, Honne, Hilde, Jebsen, Peter, Hektoen, Merete, Wadsworth, Christopher A., Clausen, Ole Petter, Lundin, Knut E.A., Paulsen, Vemund, Foss, Aksel, Mathisen, Øystein, Aabakken, Lars, Schrumpf, Erik, Lothe, Ragnhild A., Lind, Guro E.

“…Early detection of the highly aggressive malignancy cholangiocarcinoma (CCA) remains a challenge but has the potential to render the tumor curable by surgical…”
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DNA sequence profiles of the colorectal cancer critical gene set KRAS-BRAF-PIK3CA-PTEN-TP53 related to age at disease onset by Berg, Marianne, Danielsen, Stine A, Ahlquist, Terje, Merok, Marianne A, Ågesen, Trude H, Vatn, Morten H, Mala, Tom, Sjo, Ole H, Bakka, Arne, Moberg, Ingvild, Fetveit, Torunn, Mathisen, Øystein, Husby, Anders, Sandvik, Oddvar, Nesbakken, Arild, Thiis-Evensen, Espen, Lothe, Ragnhild A

“…The incidence of colorectal cancer (CRC) increases with age and early onset indicates an increased likelihood for genetic predisposition for this disease. The…”
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