Search Results - "Lotan‐Pompan, Maya"

Promoters maintain their relative activity levels under different growth conditions by Keren, Leeat, Zackay, Ora, Lotan‐Pompan, Maya, Barenholz, Uri, Dekel, Erez, Sasson, Vered, Aidelberg, Guy, Bren, Anat, Zeevi, Danny, Weinberger, Adina, Alon, Uri, Milo, Ron, Segal, Eran

“…Most genes change expression levels across conditions, but it is unclear which of these changes represents specific regulation and what determines their…”
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Large-scale mapping of gene regulatory logic reveals context-dependent repression by transcriptional activators by van Dijk, David, Sharon, Eilon, Lotan-Pompan, Maya, Weinberger, Adina, Segal, Eran, Carey, Lucas B

“…Transcription factors (TFs) are key mediators that propagate extracellular and intracellular signals through to changes in gene expression profiles. However,…”
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Personalized Nutrition by Prediction of Glycemic Responses by Zeevi, David, Korem, Tal, Zmora, Niv, Israeli, David, Rothschild, Daphna, Weinberger, Adina, Ben-Yacov, Orly, Lador, Dar, Avnit-Sagi, Tali, Lotan-Pompan, Maya, Suez, Jotham, Mahdi, Jemal Ali, Matot, Elad, Malka, Gal, Kosower, Noa, Rein, Michal, Zilberman-Schapira, Gili, Dohnalová, Lenka, Pevsner-Fischer, Meirav, Bikovsky, Rony, Halpern, Zamir, Elinav, Eran, Segal, Eran

“…Elevated postprandial blood glucose levels constitute a global epidemic and a major risk factor for prediabetes and type II diabetes, but existing dietary…”
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A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation by Kotler, Eran, Shani, Odem, Goldfeld, Guy, Lotan-Pompan, Maya, Tarcic, Ohad, Gershoni, Anat, Hopf, Thomas A., Marks, Debora S., Oren, Moshe, Segal, Eran

“…The TP53 gene is frequently mutated in human cancer. Research has focused predominantly on six major “hotspot” codons, which account for only ∼30% of…”
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Bread Affects Clinical Parameters and Induces Gut Microbiome-Associated Personal Glycemic Responses by Korem, Tal, Zeevi, David, Zmora, Niv, Weissbrod, Omer, Bar, Noam, Lotan-Pompan, Maya, Avnit-Sagi, Tali, Kosower, Noa, Malka, Gal, Rein, Michal, Suez, Jotham, Goldberg, Ben Z., Weinberger, Adina, Levy, Avraham A., Elinav, Eran, Segal, Eran

“…Bread is consumed daily by billions of people, yet evidence regarding its clinical effects is contradicting. Here, we performed a randomized crossover trial…”
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Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease by Talmor-Barkan, Yeela, Bar, Noam, Shaul, Aviv A., Shahaf, Nir, Godneva, Anastasia, Bussi, Yuval, Lotan-Pompan, Maya, Weinberger, Adina, Shechter, Alon, Chezar-Azerrad, Chava, Arow, Ziad, Hammer, Yoav, Chechi, Kanta, Forslund, Sofia K., Fromentin, Sebastien, Dumas, Marc-Emmanuel, Ehrlich, S. Dusko, Pedersen, Oluf, Kornowski, Ran, Segal, Eran

“…Complex diseases, such as coronary artery disease (CAD), are often multifactorial, caused by multiple underlying pathological mechanisms. Here, to study the…”
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Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples by Korem, Tal, Zeevi, David, Suez, Jotham, Weinberger, Adina, Avnit-Sagi, Tali, Pompan-Lotan, Maya, Matot, Elad, Jona, Ghil, Harmelin, Alon, Cohen, Nadav, Sirota-Madi, Alexandra, Thaiss, Christoph A., Pevsner-Fischer, Meirav, Sorek, Rotem, Xavier, Ramnik J., Elinav, Eran, Segal, Eran

“…Metagenomic sequencing increased our understanding of the role of the microbiome in health and disease, yet it only provides a snapshot of a highly dynamic…”
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Massively Parallel Interrogation of the Effects of Gene Expression Levels on Fitness by Keren, Leeat, Hausser, Jean, Lotan-Pompan, Maya, Vainberg Slutskin, Ilya, Alisar, Hadas, Kaminski, Sivan, Weinberger, Adina, Alon, Uri, Milo, Ron, Segal, Eran

“…Data of gene expression levels across individuals, cell types, and disease states is expanding, yet our understanding of how expression levels impact phenotype…”
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Core promoter sequence in yeast is a major determinant of expression level by Lubliner, Shai, Regev, Ifat, Lotan-Pompan, Maya, Edelheit, Sarit, Weinberger, Adina, Segal, Eran

“…The core promoter is the regulatory sequence to which RNA polymerase is recruited and where it acts to initiate transcription. Here, we present the first…”
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Involvement of a gut–retina axis in protection against dietary glycemia-induced age-related macular degeneration by Rowan, Sheldon, Jiang, Shuhong, Korem, Tal, Szymanski, Jedrzej, Chang, Min-Lee, Szelog, Jason, Cassalman, Christa, Dasuri, Kalavathi, McGuire, Christina, Nagai, Ryoji, Du, Xue-Liang, Brownlee, Michael, Rabbani, Naila, Thornalley, Paul J., Baleja, James D., Deik, Amy A., Pierce, Kerry A., Scott, Justin M., Clish, Clary B., Smith, Donald E., Weinberger, Adina, Avnit-Sagi, Tali, Lotan-Pompan, Maya, Segal, Eran, Taylor, Allen

“…Age-related macular degeneration (AMD) is the major cause of blindness in developed nations. AMD is characterized by retinal pigmented epithelial (RPE) cell…”
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Effects of personalized diets by prediction of glycemic responses on glycemic control and metabolic health in newly diagnosed T2DM: a randomized dietary intervention pilot trial by Rein, Michal, Ben-Yacov, Orly, Godneva, Anastasia, Shilo, Smadar, Zmora, Niv, Kolobkov, Dmitry, Cohen-Dolev, Noa, Wolf, Bat-Chen, Kosower, Noa, Lotan-Pompan, Maya, Weinberger, Adina, Halpern, Zamir, Zelber-Sagi, Shira, Elinav, Eran, Segal, Eran

“…Dietary modifications are crucial for managing newly diagnosed type 2 diabetes mellitus (T2DM) and preventing its health complications, but many patients fail…”
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Impact of dietary interventions on pre-diabetic oral and gut microbiome, metabolites and cytokines by Shoer, Saar, Shilo, Smadar, Godneva, Anastasia, Ben-Yacov, Orly, Rein, Michal, Wolf, Bat Chen, Lotan-Pompan, Maya, Bar, Noam, Weiss, Ervin I., Houri-Haddad, Yael, Pilpel, Yitzhak, Weinberger, Adina, Segal, Eran

“…Diabetes and associated comorbidities are a global health threat on the rise. We conducted a six-month dietary intervention in pre-diabetic individuals…”
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Systematic dissection of the sequence determinants of gene 3' end mediated expression control by Shalem, Ophir, Sharon, Eilon, Lubliner, Shai, Regev, Ifat, Lotan-Pompan, Maya, Yakhini, Zohar, Segal, Eran

“…The 3'end genomic region encodes a wide range of regulatory process including mRNA stability, 3' end processing and translation. Here, we systematically…”
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10 K: a large‐scale prospective longitudinal study in Israel by Shilo, Smadar, Bar, Noam, Keshet, Ayya, Talmor-Barkan, Yeela, Rossman, Hagai, Godneva, Anastasia, Aviv, Yaron, Edlitz, Yochai, Reicher, Lee, Kolobkov, Dmitry, Wolf, Bat Chen, Lotan-Pompan, Maya, Levi, Kohava, Cohen, Ori, Saranga, Hila, Weinberger, Adina, Segal, Eran

“…The 10 K is a large-scale prospective longitudinal cohort and biobank that was established in Israel. The primary aims of the study include development of…”
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BREAst Cancer Personalised NuTrition (BREACPNT): dietary intervention in breast cancer survivors treated with endocrine therapy – a protocol for a randomised clinical trial by Rein, Michal Sela, Dadiani, Maya, Godneva, Anastasia, Bakalenik-Gavry, Michal, Morzaev-Sulzbach, Dana, Vachnish, Yaeli, Kolobkov, Dmitry, Lotan-Pompan, maya, Weinberger, Adina, Segal, Eran, Gal-Yam, Einav Nili

“…IntroductionBreast cancer survivors treated with adjuvant endocrine therapy commonly experience weight gain, which has been associated with low adherence to…”
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Potential role of indolelactate and butyrate in multiple sclerosis revealed by integrated microbiome-metabolome analysis by Levi, Izhak, Gurevich, Michael, Perlman, Gal, Magalashvili, David, Menascu, Shay, Bar, Noam, Godneva, Anastasia, Zahavi, Liron, Chermon, Danyel, Kosower, Noa, Wolf, Bat Chen, Malka, Gal, Lotan-Pompan, Maya, Weinberger, Adina, Yirmiya, Erez, Rothschild, Daphna, Leviatan, Sigal, Tsur, Avishag, Didkin, Maria, Dreyer, Sapir, Eizikovitz, Hen, Titngi, Yamit, Mayost, Sue, Sonis, Polina, Dolev, Mark, Stern, Yael, Achiron, Anat, Segal, Eran

“…Multiple sclerosis (MS) is an immune-mediated disease whose precise etiology is unknown. Several studies found alterations in the microbiome of individuals…”
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Metabolism of soluble sugars in developing melon fruit: a global transcriptional view of the metabolic transition to sucrose accumulation by Dai, Nir, Cohen, Shahar, Portnoy, Vitaly, Tzuri, Galil, Harel-Beja, Rotem, Pompan-Lotan, Maya, Carmi, Nir, Zhang, Genfa, Diber, Alex, Pollock, Sarah, Karchi, Hagai, Yeselson, Yelena, Petreikov, Marina, Shen, Shmuel, Sahar, Uzi, Hovav, Ran, Lewinsohn, Efraim, Tadmor, Yakov, Granot, David, Ophir, Ron, Sherman, Amir, Fei, Zhangjun, Giovannoni, Jim, Burger, Yosef, Katzir, Nurit, Schaffer, Arthur A.

“…The sweet melon fruit is characterized by a metabolic transition during its development that leads to extensive accumulation of the disaccharide sucrose in the…”
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Structural variation in the gut microbiome associates with host health by Zeevi, David, Korem, Tal, Godneva, Anastasia, Bar, Noam, Kurilshikov, Alexander, Lotan-Pompan, Maya, Weinberger, Adina, Fu, Jingyuan, Wijmenga, Cisca, Zhernakova, Alexandra, Segal, Eran

“…Differences in the presence of even a few genes between otherwise identical bacterial strains may result in critical phenotypic differences. Here we…”
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Gut microbiome modulates the effects of a personalised postprandial-targeting (PPT) diet on cardiometabolic markers: a diet intervention in pre-diabetes by Ben-Yacov, Orly, Godneva, Anastasia, Rein, Michal, Shilo, Smadar, Lotan-Pompan, Maya, Weinberger, Adina, Segal, Eran

“…To explore the interplay between dietary modifications, microbiome composition and host metabolic responses in a dietary intervention setting of a personalised…”
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The human tumor microbiome is composed of tumor type-specific intracellular bacteria by Nejman, Deborah, Livyatan, Ilana, Fuks, Garold, Gavert, Nancy, Zwang, Yaara, Geller, Leore T, Rotter-Maskowitz, Aviva, Weiser, Roi, Mallel, Giuseppe, Gigi, Elinor, Meltser, Arnon, Douglas, Gavin M, Kamer, Iris, Gopalakrishnan, Vancheswaran, Dadosh, Tali, Levin-Zaidman, Smadar, Avnet, Sofia, Atlan, Tehila, Cooper, Zachary A, Arora, Reetakshi, Cogdill, Alexandria P, Khan, Md Abdul Wadud, Ologun, Gabriel, Bussi, Yuval, Weinberger, Adina, Lotan-Pompan, Maya, Golani, Ofra, Perry, Gili, Rokah, Merav, Bahar-Shany, Keren, Rozeman, Elisa A, Blank, Christian U, Ronai, Anat, Shaoul, Ron, Amit, Amnon, Dorfman, Tatiana, Kremer, Ran, Cohen, Zvi R, Harnof, Sagi, Siegal, Tali, Yehuda-Shnaidman, Einav, Gal-Yam, Einav Nili, Shapira, Hagit, Baldini, Nicola, Langille, Morgan G I, Ben-Nun, Alon, Kaufman, Bella, Nissan, Aviram, Golan, Talia, Dadiani, Maya, Levanon, Keren, Bar, Jair, Yust-Katz, Shlomit, Barshack, Iris, Peeper, Daniel S, Raz, Dan J, Segal, Eran, Wargo, Jennifer A, Sandbank, Judith, Shental, Noam, Straussman, Ravid

“…Bacteria were first detected in human tumors more than 100 years ago, but the characterization of the tumor microbiome has remained challenging because of its…”
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