Search Results - "Loskutov, Yuriy V."

Combination of Eribulin and Aurora A Inhibitor MLN8237 Prevents Metastatic Colonization and Induces Cytotoxic Autophagy in Breast Cancer by Kozyreva, Varvara K, Kiseleva, Anna A, Ice, Ryan J, Jones, Brandon C, Loskutov, Yuriy V, Matalkah, Fatimah, Smolkin, Matthew B, Marinak, Kristina, Livengood, Ryan H, Salkeni, Mohamad A, Wen, Sijin, Hazard, Hannah W, Layne, Ginger P, Walsh, Callee M, Cantrell, Pamela S, Kilby, Greg W, Mahavadi, Sricharan, Shah, Neal, Pugacheva, Elena N

“…Recent findings suggest that the inhibition of Aurora A (AURKA) kinase may offer a novel treatment strategy against metastatic cancers. In the current study,…”
Get full text

LPA signaling is regulated through the primary cilium: a novel target in glioblastoma by Loskutov, Yuriy V., Griffin, Caryn L., Marinak, Kristina M., Bobko, Andrey, Margaryan, Naira V., Geldenhuys, Werner J., Sarkaria, Jann N., Pugacheva, Elena N.

“…The primary cilium is a ubiquitous organelle presented on most human cells. It is a crucial signaling hub for multiple pathways including growth factor and…”
Get full text

Dual Targeting of Mesenchymal and Amoeboid Motility Hinders Metastatic Behavior by Jones, Brandon C, Kelley, Laura C, Loskutov, Yuriy V, Marinak, Kristina M, Kozyreva, Varvara K, Smolkin, Matthew B, Pugacheva, Elena N

“…Commonly upregulated in human cancers, the scaffolding protein NEDD9/HEF1 is a known regulator of mesenchymal migration and cancer cell plasticity. However,…”
Get full text

Prometastatic NEDD9 Regulates Individual Cell Migration via Caveolin-1-Dependent Trafficking of Integrins by Kozyulina, Polina Y, Loskutov, Yuriy V, Kozyreva, Varvara K, Rajulapati, Anuradha, Ice, Ryan J, Jones, Brandon C, Pugacheva, Elena N

“…The dissemination of tumor cells relies on efficient cell adhesion and migration, which in turn depends upon endocytic trafficking of integrins. In the current…”
Get full text

NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis by McLaughlin, Sarah L, Ice, Ryan J, Rajulapati, Anuradha, Kozyulina, Polina Y, Livengood, Ryan H, Kozyreva, Varvara K, Loskutov, Yuriy V, Culp, Mark V, Weed, Scott A, Ivanov, Alexey V, Pugacheva, Elena N

“…The scaffolding protein NEDD9 is an established prometastatic marker in several cancers. Nevertheless, the molecular mechanisms of NEDD9-driven metastasis in…”
Get full text

NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer by Loskutov, Y V, Kozyulina, P Y, Kozyreva, V K, Ice, R J, Jones, B C, Roston, T J, Smolkin, M B, Ivanov, A V, Wysolmerski, R B, Pugacheva, E N

“…NEDD9 is an established marker of invasive and metastatic cancers. NEDD9 downregulation has been shown to dramatically reduce cell invasion and metastasis in…”
Get full text

Pro-metastatic NEDD9 regulates individual cell migration via caveolin-1-dependent trafficking of integrins by Kozyulina, Polina Y., Loskutov, Yuriy V., Kozyreva, Varvara K., Rajulapati, Anuradha, Ice, Ryan J., Jones, Brandon. C., Pugacheva, Elena N.

“…The dissemination of tumor cells relies on efficient cell adhesion and migration, which in turn depends upon endocytic trafficking of integrins. In the current…”
Get full text

Implications of Primary Cilia and Associated Lysophosphatidic Acid Signaling in Glioblastoma Biology and Therapy by Loskutov, Yuriy V

“…The primary cilium is a ubiquitous organelle presented on most human cells. It serves as a crucial signaling hub for multiple pathways including growth factor…”
Get full text