Search Results - "Losiewicz, Mandy K"

Insulin-like growth factor-2 regulates basal retinal insulin receptor activity by Zolov, Sergey N., Imai, Hisanori, Losiewicz, Mandy K., Singh, Ravi S.J., Fort, Patrice E., Gardner, Thomas W.

“…The retinal insulin receptor (IR) exhibits basal kinase activity equivalent to that of the liver of fed animals, but unlike the liver, does not fluctuate with…”
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mTORC1 and mTORC2 expression in inner retinal neurons and glial cells by Losiewicz, Mandy K., Elghazi, Lynda, Fingar, Diane C., Rajala, Raju V.S., Lentz, Stephen I., Fort, Patrice E., Abcouwer, Steven F., Gardner, Thomas W.

“…The retina is one of the most metabolically active tissues, yet the processes that control retinal metabolism remains poorly understood. The mTOR complex…”
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Differential roles of hyperglycemia and hypoinsulinemia in diabetes induced retinal cell death: evidence for retinal insulin resistance by Fort, Patrice E, Losiewicz, Mandy K, Reiter, Chad E N, Singh, Ravi S J, Nakamura, Makoto, Abcouwer, Steven F, Barber, Alistair J, Gardner, Thomas W

“…Diabetes pathology derives from the combination of hyperglycemia and hypoinsulinemia or insulin resistance leading to diabetic complications including diabetic…”
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mTORC1 -Independent Reduction of Retinal Protein Synthesis in Type 1 Diabetes by FORT, Patrice E, LOSIEWICZ, Mandy K, PENNATHUR, Subramaniam, JEFFERSON, Leonard S, KIMBALL, Scot R, ABCOUWER, Steven F, GARDNER, Thomas W

“…Poorly controlled diabetes has long been known as a catabolic disorder with profound loss of muscle and fat body mass resulting from a simultaneous reduction…”
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Diabetes impairs the neuroprotective properties of retinal alpha-crystallins by Losiewicz, Mandy K, Fort, Patrice E

“…α-Crystallins are small heat shock proteins that regulate cellular damage and cell survival. Expression of the proteins of the crystallin superfamily in the…”
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mTORC1 regulates high levels of protein synthesis in retinal ganglion cells of adult mice by Fort, Patrice E., Losiewicz, Mandy K., Elghazi, Lynda, Kong, Dejuan, Cras-Méneur, Corentin, Fingar, Diane C., Kimball, Scot R., Rajala, Raju V.S., Smith, Alexander J., Ali, Robin R., Abcouwer, Steven F., Gardner, Thomas W.

“…Mechanistic target of rapamycin (mTOR) and mTOR complex 1 (mTORC1), linchpins of the nutrient sensing and protein synthesis pathways, are present at relatively…”
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Phosphatase control of 4E-BP1 phosphorylation state is central for glycolytic regulation of retinal protein synthesis by Gardner, Thomas W, Abcouwer, Steven F, Losiewicz, Mandy K, Fort, Patrice E

“…Control of protein synthesis in insulin-responsive tissues has been well characterized, but relatively little is known about how this process is regulated in…”
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The Retinal Proteome in Experimental Diabetic Retinopathy by Fort, Patrice E., Freeman, Willard M., Losiewicz, Mandy K., Singh, Ravi S.J., Gardner, Thomas W.

“…Diabetic retinopathy is the leading cause of blindness in working age persons. Targeted studies have uncovered several components of the pathophysiology of the…”
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The retinal proteome in experimental diabetic retinopathy: up-regulation of crystallins and reversal by systemic and periocular insulin by Fort, Patrice E, Freeman, Willard M, Losiewicz, Mandy K, Singh, Ravi S J, Gardner, Thomas W

“…Diabetic retinopathy is the leading cause of blindness in working age persons. Targeted studies have uncovered several components of the pathophysiology of the…”
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