Search Results - "Losi, Gabriele"

The inhibitory neurotransmitter GABA evokes long-lasting Ca2+ oscillations in cortical astrocytes by Mariotti, Letizia, Losi, Gabriele, Sessolo, Michele, Marcon, Iacopo, Carmignoto, Giorgio

“…Studies over the last decade provided evidence that in a dynamic interaction with neurons glial cell astrocytes contribut to fundamental phenomena in the…”
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Calcium Signals in Astrocyte Microdomains, a Decade of Great Advances by Lia, Annamaria, Henriques, Vanessa Jorge, Zonta, Micaela, Chiavegato, Angela, Carmignoto, Giorgio, Gómez-Gonzalo, Marta, Losi, Gabriele

“…The glial cells astrocytes have long been recognized as important neuron-supporting elements in brain development, homeostasis, and metabolism. After the…”
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Interneuron-specific signaling evokes distinctive somatostatin-mediated responses in adult cortical astrocytes by Mariotti, Letizia, Losi, Gabriele, Lia, Annamaria, Melone, Marcello, Chiavegato, Angela, Gómez-Gonzalo, Marta, Sessolo, Michele, Bovetti, Serena, Forli, Angelo, Zonta, Micaela, Requie, Linda Maria, Marcon, Iacopo, Pugliese, Arianna, Viollet, Cécile, Bettler, Bernhard, Fellin, Tommaso, Conti, Fiorenzo, Carmignoto, Giorgio

“…The signaling diversity of GABAergic interneurons to post-synaptic neurons is crucial to generate the functional heterogeneity that characterizes brain…”
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High-throughput screening of the static friction and ideal cleavage strength of solid interfaces by Wolloch, Michael, Losi, Gabriele, Ferrario, Mauro, Righi, M. Clelia

“…We present a comprehensive ab initio , high-throughput study of the frictional and cleavage strengths of interfaces of elemental crystals with different…”
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Cellular and molecular mechanisms of new onset seizure generation by Losi, Gabriele, Gomez-Gonzalo, Marta, Zonta, Micaela, Chiavegato, Angela, Carmignoto, Giorgio

“…New onset epilepsy and seizures are common neurological disorders in aged people, second only to stroke and dementia. They are frequently related to other…”
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New Tools to Study Astrocyte Ca2+ Signal Dynamics in Brain Networks In Vivo by Losi, Gabriele, Mariotti, Letizia, Sessolo, Michele, Carmignoto, Giorgio

“…Sensory information processing is a fundamental operation in the brain that is based on dynamic interactions between different neuronal populations…”
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Altered Cl⁻ homeostasis hinders forebrain GABAergic interneuron migration in a mouse model of intellectual disability by Maset, Andrea, Galla, Luisa, Francia, Simona, Cozzolino, Olga, Capasso, Paola, Goisis, Rosa Chiara, Losi, Gabriele, Lombardo, Angelo, Ratto, Gian Michele, Lodovichi, Claudia

“…Impairments of inhibitory circuits are at the basis of most, if not all, cognitive deficits. The impact of OPHN1, a gene associate with intellectual disability…”
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An excitatory loop with astrocytes contributes to drive neurons to seizure threshold by Gómez-Gonzalo, Marta, Losi, Gabriele, Chiavegato, Angela, Zonta, Micaela, Cammarota, Mario, Brondi, Marco, Vetri, Francesco, Uva, Laura, Pozzan, Tullio, de Curtis, Marco, Ratto, Gian Michele, Carmignoto, Giorgio

“…Seizures in focal epilepsies are sustained by a highly synchronous neuronal discharge that arises at restricted brain sites and subsequently spreads to large…”
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GABA tonic currents and glial cells are altered during epileptogenesis in a mouse model of Dravet syndrome by Goisis, Rosa Chiara, Chiavegato, Angela, Gomez-Gonzalo, Marta, Marcon, Iacopo, Requie, Linda Maria, Scholze, Petra, Carmignoto, Giorgio, Losi, Gabriele

“…Dravet Syndrome (DS) is a rare autosomic encephalopathy with epilepsy linked to Na v 1.1 channel mutations and defective GABAergic signaling. Effective…”
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Ion Channels and Ionotropic Receptors in Astrocytes: Physiological Functions and Alterations in Alzheimer’s Disease and Glioblastoma by Lia, Annamaria, Di Spiezio, Alessandro, Vitalini, Lorenzo, Tore, Manuela, Puja, Giulia, Losi, Gabriele

“…The human brain is composed of nearly one hundred billion neurons and an equal number of glial cells, including macroglia, i.e., astrocytes and…”
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A brain slice experimental model to study the generation and the propagation of focally-induced epileptiform activity by Losi, Gabriele, Marcon, Iacopo, Mariotti, Letizia, Sessolo, Michele, Chiavegato, Angela, Carmignoto, Giorgio

“…•We propose a model of seizure-like events in temporal cortex slices from young mice.•In the model local NMDA stimulations induce multiple seizure-like…”
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Corrigendum: GABA tonic currents and glial cells are altered during epileptogenesis in a mouse model of Dravet syndrome by Goisis, Rosa Chiara, Chiavegato, Angela, Gomez-Gonzalo, Marta, Marcon, Iacopo, Requie, Linda Maria, Scholze, Petra, Carmignoto, Giorgio, Losi, Gabriele

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Modulation of NMDA receptor activity by CR4056, an imidazoline-2 receptor ligand with analgesic properties by Puja, Giulia, Losi, Gabriele, Rovati, Lucio, Lanza, Marco, Caselli, Gianfranco, Bardoni, Rita

“…CR4056 is an imidazoline-2 receptor ligand having potent analgesic activity and synergistic effect with opioids. Very recently it has been found that CR4056…”
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The role of astroglia in the epileptic brain by Losi, Gabriele, Cammarota, Mario, Carmignoto, Giorgio

“…Epilepsies comprise a family of multifactorial neurological disorders that affect at least 50 million people worldwide. Despite a long history of…”
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The inflammatory molecules IL-1β and HMGB1 can rapidly enhance focal seizure generation in a brain slice model of temporal lobe epilepsy by Chiavegato, Angela, Zurolo, Emanuele, Losi, Gabriele, Aronica, Eleonora, Carmignoto, Giorgio

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Apigenin modulates GABAergic and glutamatergic transmission in cultured cortical neurons by Losi, Gabriele, Puia, Giulia, Garzon, Giorgio, de Vuono, Maria C., Baraldi, Mario

“…Using the patch-clamp technique, we studied the modulation of ionotropic γ-aminobutyric acid (GABA) and glutamate neurotransmission by apigenin, a flavonoid…”
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PSD-95 regulates NMDA receptors in developing cerebellar granule neurons of the rat by Losi, Gabriele, Prybylowski, Kate, Fu, Zhanyan, Luo, Jianhong, Wenthold, Robert J, Vicini, Stefano

“…We transfected a green fluorescent protein-tagged PSD-95 (PSD-95gfp) into cultured rat cerebellar granule cells (CGCs) to investigate the role of PSD-95 in…”
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The inhibitory neurotransmitter GABA evokes long-lasting Ca(2+) oscillations in cortical astrocytes by Mariotti, Letizia, Losi, Gabriele, Sessolo, Michele, Marcon, Iacopo, Carmignoto, Giorgio

“…Studies over the last decade provided evidence that in a dynamic interaction with neurons glial cell astrocytes contribut to fundamental phenomena in the…”
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Fast spiking interneuron control of seizure propagation in a cortical slice model of focal epilepsy by Cammarota, Mario, Losi, Gabriele, Chiavegato, Angela, Zonta, Micaela, Carmignoto, Giorgio

“…Key points In focal epilepsy the propagation of seizure discharges arising at restricted brain sites is opposed by feedforward inhibition. Failure of this…”
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GABAergic interneuron to astrocyte signalling: a neglected form of cell communication in the brain by Losi, Gabriele, Mariotti, Letizia, Carmignoto, Giorgio

“…GABAergic interneurons represent a minority of all cortical neurons and yet they efficiently control neural network activities in all brain areas. In parallel,…”
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