Search Results - "Losche, Mathias"

A bacteriophage endolysin that eliminates intracellular streptococci by Shen, Yang, Barros, Marilia, Vennemann, Tarek, Gallagher, D Travis, Yin, Yizhou, Linden, Sara B, Heselpoth, Ryan D, Spencer, Dennis J, Donovan, David M, Moult, John, Fischetti, Vincent A, Heinrich, Frank, Lösche, Mathias, Nelson, Daniel C

“…PlyC, a bacteriophage-encoded endolysin, lyses Streptococcus pyogenes (Spy) on contact. Here, we demonstrate that PlyC is a potent agent for controlling…”
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Neutron Reflectometry and Molecular Simulations Demonstrate HIV-1 Nef Homodimer Formation on Model Lipid Bilayers by Heinrich, Frank, Thomas, Catherine E., Alvarado, John J., Eells, Rebecca, Thomas, Alyssa, Doucet, Mathieu, Whitlatch, Kindra N., Aryal, Manish, Lösche, Mathias, Smithgall, Thomas E.

“…[Display omitted] •HIV-1 Nef is essential for viral pathogenesis and often functions as a homodimer.•Neutron reflectometry revealed myristoylated Nef…”
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Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane by Van, Que N., López, Cesar A., Tonelli, Marco, Taylor, Troy, Niu, Ben, Stanley, Christopher B., Bhowmik, Debsindhu, Tran, Timothy H., Frank, Peter H., Messing, Simon, Alexander, Patrick, Scott, Daniel, Ye, Xiaoying, Drew, Matt, Chertov, Oleg, Lösche, Mathias, Ramanathan, Arvind, Gross, Michael L., Hengartner, Nicolas W., Westler, William M., Markley, John L., Simanshu, Dhirendra K., Nissley, Dwight V., Gillette, William K., Esposito, Dominic, McCormick, Frank, Gnanakaran, S., Heinrich, Frank, Stephen, Andrew G.

“…The small GTPase KRAS is localized at the plasma membrane where it functions as a molecular switch, coupling extracellular growth factor stimulation to…”
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Optimization of reflectometry experiments using information theory by Treece, Bradley W., Kienzle, Paul A., Hoogerheide, David P., Majkrzak, Charles F., Lösche, Mathias, Heinrich, Frank

“…A framework based on Bayesian statistics and information theory is developed to optimize the design of surface‐sensitive reflectometry experiments. The method…”
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Soluble Amyloid β-Oligomers Affect Dielectric Membrane Properties by Bilayer Insertion and Domain Formation: Implications for Cell Toxicity by Valincius, Gintaras, Heinrich, Frank, Budvytyte, Rima, Vanderah, David J., McGillivray, Duncan J., Sokolov, Yuri, Hall, James E., Lösche, Mathias

“…It is well established that Alzheimer's amyloid β-peptides reduce the membrane barrier to ion transport. The prevailing model ascribes the resulting…”
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Single wall carbon nanotubes enter cells by endocytosis and not membrane penetration by Yaron, Peter N, Holt, Brian D, Short, Philip A, Lösche, Mathias, Islam, Mohammad F, Dahl, Kris Noel

“…Carbon nanotubes are increasingly being tested for use in cellular applications. Determining the mode of entry is essential to control and regulate specific…”
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HIV-1 matrix-31 membrane binding peptide interacts differently with membranes containing PS vs. PI(4,5)P 2 by O'Neil, Lauren, Andenoro, Kathryn, Pagano, Isabella, Carroll, Laura, Langer, Leah, Dell, Zachary, Perera, Davina, Treece, Bradley W, Heinrich, Frank, Lösche, Mathias, Nagle, John F, Tristram-Nagle, Stephanie

“…Efficient assembly of HIV-1 at the plasma membrane (PM) of the T-cell specifically requires PI(4,5)P . It was previously shown that a highly basic region (HBR)…”
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Structural characterization of membrane-bound human immunodeficiency virus-1 Gag matrix with neutron reflectometry by Eells, Rebecca, Barros, Marilia, Scott, Kerry M, Karageorgos, Ioannis, Heinrich, Frank, Lösche, Mathias

“…The structural characterization of peripheral membrane proteins represents a tremendous challenge in structural biology due to their transient interaction with…”
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Membrane surface recognition by the ASAP1 PH domain and consequences for interactions with the small GTPase Arf1 by Soubias, Olivier, Pant, Shashank, Heinrich, Frank, Zhang, Yue, Roy, Neeladri Sekhar, Li, Jess, Jian, Xiaoying, Yohe, Marielle E, Randazzo, Paul A, Lösche, Mathias, Tajkhorshid, Emad, Byrd, R Andrew

“…Adenosine diphosphate-ribosylation factor (Arf) guanosine triphosphatase-activating proteins (GAPs) are enzymes that need to bind to membranes to catalyze the…”
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Molecular-scale structural and functional characterization of sparsely tethered bilayer lipid membranes by McGillivray, Duncan J, Valincius, Gintaras, Vanderah, David J, Febo-Ayala, Wilma, Woodward, John T, Heinrich, Frank, Kasianowicz, John J, Lösche, Mathias

“…Surface-tethered biomimetic bilayer membranes (tethered bilayer lipid membranes (tBLMs)) were formed on gold surfaces from phospholipids and a synthetic…”
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Steering Molecular Dynamics Simulations of Membrane-Associated Proteins with Neutron Reflection Results by Treece, Bradley W, Heinrich, Frank, Ramanathan, Arvind, Lösche, Mathias

“…We present a novel method to incorporate structural results from surface-sensitive scattering, such as X-ray or neutron reflectometry, into molecular dynamics…”
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Association of Model Neurotransmitters with Lipid Bilayer Membranes by Josey, Brian P., Heinrich, Frank, Silin, Vitalii, Lösche, Mathias

“…Aimed at reproducing the results of electrophysiological studies of synaptic signal transduction, conventional models of neurotransmission are based on the…”
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Charge Effects Provide Ångström-Level Control of Lipid Bilayer Morphology on Titanium Dioxide Surfaces by Michalak, Dennis J, Lösche, Mathias, Hoogerheide, David P

“…Interfaces between molecular organic architectures and oxidic substrates are a central feature of biosensors and applications of biomimetics in science and…”
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A New Lipid Anchor for Sparsely Tethered Bilayer Lipid Membranes by Heinrich, Frank, Ng, Tiffany, Vanderah, David J, Shekhar, Prabhanshu, Mihailescu, Mihaela, Nanda, Hirsh, Lösche, Mathias

“…Mixed self-assembled monolayers (SAMs) of β-mercaptoethanol and the new synthetic lipid 1,2-dipalmityl-3-[ω-mercaptonona(ethylene oxide)] glycerol (FC16) were…”
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Information gain from isotopic contrast variation in neutron reflectometry on protein–membrane complex structures by Heinrich, Frank, Kienzle, Paul A., Hoogerheide, David P., Lösche, Mathias

“…A framework is applied to quantify information gain from neutron or X‐ray reflectometry experiments [Treece, Kienzle, Hoogerheide, Majkrzak, Lösche & Heinrich…”
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Structural and biophysical properties of farnesylated KRas interacting with the chaperone SmgGDS-558 by Michalak, Dennis J., Unger, Bethany, Lorimer, Ellen, Grishaev, Alexander, Williams, Carol L., Heinrich, Frank, Lösche, Mathias

“…KRas is a small GTPase and membrane-bound signaling protein. Newly synthesized KRas is post-translationally modified with a membrane-anchoring prenyl group…”
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Membrane Anchoring of Hck Kinase via the Intrinsically Disordered SH4-U and Length Scale Associated with Subcellular Localization by Pond, Matthew P., Eells, Rebecca, Treece, Bradley W., Heinrich, Frank, Lösche, Mathias, Roux, Benoît

“…Src family kinases (SFKs) are a group of nonreceptor tyrosine kinases that are characterized by their involvement in critical signal transduction pathways…”
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Structure and Properties of Tethered Bilayer Lipid Membranes with Unsaturated Anchor Molecules by Budvytyte, Rima, Valincius, Gintaras, Niaura, Gediminas, Voiciuk, Vladislava, Mickevicius, Mindaugas, Chapman, Hilary, Goh, Haw-Zan, Shekhar, Prabhanshu, Heinrich, Frank, Shenoy, Siddharth, Lösche, Mathias, Vanderah, David J

“…The self-assembled monolayers (SAMs) of new lipidic anchor molecule HC18 [Z-20-(Z-octadec-9-enyloxy)-3,6,9,12,15,18,22-heptaoxatetracont-31-ene-1-thiol] and…”
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Membrane Binding of HIV-1 Matrix Protein: Dependence on Bilayer Composition and Protein Lipidation by Barros, Marilia, Heinrich, Frank, Datta, Siddhartha A K, Rein, Alan, Karageorgos, Ioannis, Nanda, Hirsh, Lösche, Mathias

“…By assembling in a protein lattice on the host's plasma membrane, the retroviral Gag polyprotein triggers formation of the viral protein/membrane shell. The MA…”
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Myr-Arf1 conformational flexibility at the membrane surface sheds light on the interactions with ArfGAP ASAP1 by Zhang, Yue, Soubias, Olivier, Pant, Shashank, Heinrich, Frank, Vogel, Alexander, Li, Jess, Li, Yifei, Clifton, Luke A., Daum, Sebastian, Bacia, Kirsten, Huster, Daniel, Randazzo, Paul A., Lösche, Mathias, Tajkhorshid, Emad, Byrd, R. Andrew

“…ADP-ribosylation factor 1 (Arf1) interacts with multiple cellular partners and membranes to regulate intracellular traffic, organelle structure and actin…”
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