Search Results - "Losada Galván, Irene"
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Does Progressive Introduction of Benznidazole Reduce the Chance of Adverse Events in the Treatment of Chagas Disease?
Published in The American journal of tropical medicine and hygiene (01-01-2019)“…In this retrospective cohort study, we aimed to assess whether introducing benznidazole at escalating doses reduces the probability of adverse events or…”
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How do we classify organ involvement in Chagas disease? A systematic review of organ involvement since 1909, Highlighting the urgent need for a universal classification system in Chronic Chagas disease
Published in PLoS neglected tropical diseases (05-08-2024)“…Chagas disease (CD) is recognized as one of the 20 neglected tropical diseases by the World Health Organization (WHO), posing a significant global health…”
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Relevance of screening for Chagas and viral hepatitis in Bolivian migrants
Published in Medicina clinica (23-07-2021)“…Given the scarcity of data regarding prevalence of various infectious diseases in Latin-American countries, our study aims to assess the burden of T. cruzi, S…”
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A guide for the generation of repositories of clinical samples for research on Chagas disease
Published in PLoS neglected tropical diseases (15-08-2024)“…Chagas disease, caused by the parasite Trypanosoma cruzi, affects over 6 million people, mainly in Latin America. Two different clinical phases, acute and…”
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Clinical use of molecular methods for Trypanosoma cruzi infection in endemic and non-endemic countries: Benefits, limitations and challenges
Published in Frontiers in parasitology (21-11-2023)“…Trypanosoma cruzi infection is diagnosed by parasitological, molecular, and serological tests. Molecular methods based on DNA amplification provide a more…”
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Transcriptomic evidence of immune modulation in subjects with chronic Trypanosoma cruzi infection
Published in The Journal of infectious diseases (28-08-2024)“…Chagas disease is a neglected tropical infection that affects millions of people. This study explores transcriptomic changes in T. cruzi-infected subjects…”
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Changes in lipid abundance are associated with disease progression and treatment response in chronic Trypanosoma cruzi infection
Published in Parasites & vectors (09-11-2024)“…Chagas disease, caused by the parasite Trypanosoma cruzi, is a zoonosis that affects more than seven million people. Current limitations on the diagnosis of…”
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A standardized clinical database for research in Chagas disease: The NHEPACHA network
Published in PLoS neglected tropical diseases (15-08-2024)“…The NHEPACHA Iberoamerican Network, founded on the initiative of a group of researchers from Latin American countries and Spain, aims to establish a research…”
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Characterization of Latin American migrants at risk for Trypanosoma cruzi infection in a non-endemic setting. Insights into initial evaluation of cardiac and digestive involvement
Published in PLoS neglected tropical diseases (01-07-2023)“…Trypanosoma cruzi causes Chagas disease (CD), a potentially fatal disease characterized by cardiac disorders and digestive, neurological or mixed alterations…”
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Relevance of screening for Chagas and viral hepatitis in Bolivian migrants
Published in Medicina clínica (English ed.) (23-07-2021)“…Given the scarcity of data regarding prevalence of various infectious diseases in Latin-American countries, our study aims to assess the burden of T. cruzi, S…”
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State-of-the-art in host-derived biomarkers of Chagas disease prognosis and early evaluation of anti-Trypanosoma cruzi treatment response
Published in Biochimica et biophysica acta. Molecular basis of disease (01-07-2020)“…Chagas disease is caused by infection with the parasite Trypanosoma cruzi, which might lead to a chronic disease state and drive to irreversible damage to the…”
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Quality assurance of serologic testing for Chagas disease in a primary care setting of rural Paraguay
Published in Acta tropica (01-11-2024)“…•ELISA kits to detect T. cruzi in different settings showed good agreement.•Performance of ELISA kits in rural areas could be affected by operator…”
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Emerging agents for the treatment of Chagas disease: what is in the preclinical and clinical development pipeline?
Published in Expert opinion on investigational drugs (01-09-2020)“…Chagas disease treatment relies on the lengthy administration of benznidazole and/or nifurtimox, which have frequent toxicity associated. The disease, caused…”
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