Search Results - "Lormeau, Jean Claude"

Synthesis of thrombin-inhibiting heparin mimetics without side effects by Herbert, Jean-Marc, Petitou, Maurice, Hérault, Jean-Pascal, Bernat, André, Driguez, Pierre-Alexandre, Duchaussoy, Philippe, Lormeau, Jean-Claude

“…Unwanted side effects of pharmacologically active compounds can usually be eliminated by structural modifications. But the complex heterogeneous structure of…”
Get full text

Human umbilical vein endothelial cells express high affinity receptors for factor Xa by Bono, Françoise, Herault, Jean-Pascal, Avril, Corinne, Schaeffer, Paul, Lormeau, Jean-Claude, Herbert, Jean-Marc

“…The binding of [125I]‐factor Xa to human umbilical vein endothelial cell (HUVEC) monolayers was studied. At 7°C, [125I]‐factor Xa bound to a single class of…”
Get full text

Heparin-derived oligosaccharides: affinity for acidic fibroblast growth factor and effect on its growth-promoting activity for human endothelial cells by Bârzu, T, Lormeau, J C, Petitou, M, Michelson, S, Choay, J

“…The minimal structural requirements for the interaction of heparin with acidic fibroblast growth factor (aFGF) were investigated. Oligosaccharides (tetra- to…”
Get more information

Structural studies on a biologically active hexasaccharide obtained from heparin by Choay, J, Lormeau, J C, Petitou, M, Sinaÿ, P, Fareed, J

Get more information

Synthesis and Pharmacological Properties of a Close Analogue of an Antithrombotic Pentasaccharide (SR 90107A/ORG 31540) by Petitou, Maurice, Duchaussoy, Philippe, Jaurand, Guy, Gourvenec, Françoise, Lederman, Isidore, Strassel, Jean-Marc, Bârzu, Tereza, Crépon, Bertrand, Hérault, Jean-Pascal, Lormeau, Jean-Claude, Bernat, André, Herbert, Jean-Marc

“…The synthetic pentasaccharide (1) corresponding to the heparin sequence which binds to, and activates, antithrombin III (AT III) is a potent antithrombotic…”
Get full text

Synthetic oligosaccharides having various functional domains: Potent and potentially safe heparin mimetics by Petitou, Maurice, Driguez, Pierre-Alexandre, Duchaussoy, Philippe, Hérault, Jean-Pascal, Lormeau, Jean-Claude, Herbert, Jean-Marc

“…A synthetic heptadecasaccharide, comprising an antithrombin III binding domain, a thrombin binding domain, and a neutral methylated hexasaccharide sequence,…”
Get full text

Introducing a C-interglycosidic bond in a biologically active pentasaccharide hardly affects its biological properties by Petitou, M, Hérault, J P, Lormeau, J C, Helmboldt, A, Mallet, J M, Sinaÿ, P, Herbert, J M

“…We describe here the synthesis and the biological activity of a 'C-pentasaccharide', a new analogue of the antithrombin III (AT III) binding region of heparin…”
Get full text

Contribution of monosaccharide residues in heparin binding to antithrombin III by Atha, Donald H, Lormeau, Jean Claude, Petitou, Maurice, Rosenberg, Robert D, Choay, Jean

“…The importance of 3-O- and 6-O-sulfated glucosamine residues within the heparin octasaccharide iduronic acid(1)---N-acetylglucosamine…”
Get full text

Synthesis and biological activity of a new anti-factor Xa pentasaccharide with a C-interglycosidic bond by Helmboldt, Arnim, Petitou, Maurice, Mallet, Jean-Maurice, Hérault, Jean-Pascal, Lormeau, Jean-Claude, Driguez, Pierre Alexandre, Herbert, Jean-Marc, Sinaÿ, Pierre

“…A mixed synthetic C, O-pentasaccharide 17 has been synthesized and shown to display an anti-factor Xa activity similar to that of the corresponding…”
Get full text

Comparative inhibition of extrinsic and intrinsic thrombin generation by standard heparin, a low molecular weight heparin and the synthetic ATIII-binding pentasaccharide by Lormeau, J C, Herault, J P

“…The inhibiting effect of standard heparin, CY216 and the ATIII-binding synthetic pentasaccharide on extrinsic and intrinsic thrombin generation were quantified…”
Get more information

Studies on the structural requirements of heparin for the catalysis of thrombin inhibition by heparin cofactor II by Sié, P, Petitou, M, Lormeau, J C, Dupouy, D, Boneu, B, Choay, J

“…The structural requirements of heparin for the catalysis of thrombin inhibition by heparin cofactor II (HC II) were investigated. A series of well…”
Get more information

O-acylated heparin derivatives with low anticoagulant activity decrease proliferation and increase alpha-smooth muscle actin expression in cultured arterial smooth muscle cells by Bârzu, T, Desmoulière, A, Herbert, J M, Level, M, Herault, J P, Petitou, M, Lormeau, J C, Gabbiani, G, Pascal, M

“…Selectively O-acylated derivatives of various glycosaminoglycans were prepared and tested in vitro for their anticoagulant activity and their antiproliferative…”
Get more information

Interaction of heparin and antithrombin III: the role of O-sulfate groups by PETITOU, M, LORMEAU, J.-C, CHOAY, J

“…A synthetic pentasaccharide corresponding to the sequence involved in heparin for binding and activation of antithrombin III contains eight sulfate groups. The…”
Get full text

Contribution of 3-O- and 6-O-sulfated glucosamine residues in the heparin-induced conformational change in antithrombin III by Atha, Donald H, Lormeau, Jean Claude, Petitou, Maurice, Rosenberg, Robert D, Choay, Jean

“…The role of 3-O- and 6-O-sulfated glucosamine residues within the heparin octasaccharide critical for biological activity, iduronic acid---N-acetylglucosamine…”
Get full text

Antithrombin-mediated inhibition of factor VIIa-tissue factor complex by the synthetic pentasaccharide representing the heparin binding site to antithrombin by Lormeau, J C, Herault, J P, Herbert, J M

“…We examined the effect of the synthetic pentasaccharide representing the minimal binding site of heparin to antithrombin on the antithrombin-mediated…”
Get more information

Chemical synthesis of glycosaminoglycans : new approaches to antithrombotic drugs by PETITOU, M, LORMEAU, J.-C, CHOAY, J

“…Sanofi, Elf Aquitaine's pharmaceutical subsidiary, is a world leader in the manufacturing of antithrombotic drugs. The development of Heparin-based…”
Get full text

Contribution of 3-0- and 6-0-sulfated glucosamine residues in the heparin-induced conformational change in antithrombin III by ATHA, D. H, LORMEAU, J.-C, PETITOU, M, ROSENBERG, R. D, CHOAY, J

Get full text

Preparation and anti-HIV activity of O-acylated heparin and dermatan sulfate derivatives with low anticoagulant effect by Barzu, Tereza, Level, Michel, Petitou, Maurice, Lormeau, Jean Claude, Choay, Jean, Schols, Dominique, Baba, Masanori, Pauwels, Rudi, Witvrouw, Myriam, De Clercq, Erik

“…In order to increase the ratio of anti-HIV activity to anticoagulant activity, glycosaminoglycan derivatives selectively substituted at OH and/or COOH groups…”
Get full text

Structural Determinants of the Capacity of Heparin to Inhibit the Proliferation of Vascular Smooth Muscle Cells. II. Evidence for a Pentasaccharide Sequence That Contains a 3-O-Sulfate Group by Castellot, John J., Choay, Jean, Lormeau, Jean-Claude, Petitou, Maurice, Sache, Edgar, Karnovsky, Morris J.

“…Earlier work from our laboratory demonstrated that heparin inhibited the proliferation of vascular smooth muscle cells in vivo and in vitro. Both anticoagulant…”
Get full text

DETERMINATION OF THE ANTI-FACTOR Xa ACTIVITY OF THE SYNTHETIC PENTASACCHARIDE SR 90107A/ORG 31540 AND OF TWO STRUCTURAL ANALOGUES by Lormeau, Jean Claude, Herault, Jean Pascal, Gaich, Colette, Barzu, Teresa, van Dinther, Theo G., Visser, Arie, Herbert, Jean Marc

“…The anti-factor Xa activity of the synthetic pentasaccharide SR 90107A/ORG 31540 was assayed by a chromogenic method at pH 8.4 and pH 7.35, comparatively to…”
Get full text