Search Results - "Lorito, Nicla"

Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer by Bacci, Marina, Lorito, Nicla, Ippolito, Luigi, Ramazzotti, Matteo, Luti, Simone, Romagnoli, Simone, Parri, Matteo, Bianchini, Francesca, Cappellesso, Federica, Virga, Federico, Gao, Qiong, Simões, Bruno M., Marangoni, Elisabetta, Martin, Lesley-Ann, Comito, Giuseppina, Ferracin, Manuela, Giannoni, Elisa, Mazzone, Massimiliano, Chiarugi, Paola, Morandi, Andrea

“…Endocrine therapy (ET) is the standard of care for estrogen receptor-positive (ER+) breast cancers. Despite its efficacy, ∼40% of women relapse with…”
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Oxidative phosphorylation is a metabolic vulnerability of endocrine therapy and palbociclib resistant metastatic breast cancers by El-Botty, Rania, Morriset, Ludivine, Montaudon, Elodie, Tariq, Zakia, Schnitzler, Anne, Bacci, Marina, Lorito, Nicla, Sourd, Laura, Huguet, Léa, Dahmani, Ahmed, Painsec, Pierre, Derrien, Heloise, Vacher, Sophie, Masliah-Planchon, Julien, Raynal, Virginie, Baulande, Sylvain, Larcher, Thibaut, Vincent-Salomon, Anne, Dutertre, Guillaume, Cottu, Paul, Gentric, Géraldine, Mechta-Grigoriou, Fatima, Hutton, Scott, Driouch, Keltouma, Bièche, Ivan, Morandi, Andrea, Marangoni, Elisabetta

“…Resistance to endocrine treatments and CDK4/6 inhibitors is considered a near-inevitability in most patients with estrogen receptor positive breast cancers (ER…”
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Sex difference in liver diseases: How preclinical models help to dissect the sex-related mechanisms sustaining NAFLD and hepatocellular carcinoma by Smiriglia, Alfredo, Lorito, Nicla, Serra, Marina, Perra, Andrea, Morandi, Andrea, Kowalik, Marta Anna

“…Only a few preclinical findings are confirmed in the clinic, posing a critical issue for clinical development. Therefore, identifying the best preclinical…”
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FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer by Lorito, Nicla, Subbiani, Angela, Smiriglia, Alfredo, Bacci, Marina, Bonechi, Francesca, Tronci, Laura, Romano, Elisabetta, Corrado, Alessia, Longo, Dario Livio, Iozzo, Marta, Ippolito, Luigi, Comito, Giuseppina, Giannoni, Elisa, Meattini, Icro, Avgustinova, Alexandra, Chiarugi, Paola, Bachi, Angela, Morandi, Andrea

“…Triple-negative breast cancer (TNBC) has limited therapeutic options, is highly metastatic and characterized by early recurrence. Lipid metabolism is generally…”
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Glucose Metabolic Reprogramming of ER Breast Cancer in Acquired Resistance to the CDK4/6 Inhibitor Palbociclib by Lorito, Nicla, Bacci, Marina, Smiriglia, Alfredo, Mannelli, Michele, Parri, Matteo, Comito, Giuseppina, Ippolito, Luigi, Giannoni, Elisa, Bonechi, Martina, Benelli, Matteo, Migliaccio, Ilenia, Malorni, Luca, Chiarugi, Paola, Morandi, Andrea

“…The majority of breast cancers express the estrogen receptor (ER) and are dependent on estrogen for their growth and survival. Endocrine therapy (ET) is the…”
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Fat and Furious: Lipid Metabolism in Antitumoral Therapy Response and Resistance by Bacci, Marina, Lorito, Nicla, Smiriglia, Alfredo, Morandi, Andrea

“…Lipid metabolic reprogramming is an established trait of cancer metabolism that guides response and resistance to antitumoral therapies. Enhanced lipogenesis,…”
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Lactate Rewires Lipid Metabolism and Sustains a Metabolic-Epigenetic Axis in Prostate Cancer by Ippolito, Luigi, Comito, Giuseppina, Parri, Matteo, Iozzo, Marta, Duatti, Assia, Virgilio, Francesca, Lorito, Nicla, Bacci, Marina, Pardella, Elisa, Sandrini, Giada, Bianchini, Francesca, Damiano, Roberta, Ferrone, Lavinia, la Marca, Giancarlo, Serni, Sergio, Spatafora, Pietro, Catapano, Carlo V, Morandi, Andrea, Giannoni, Elisa, Chiarugi, Paola

“…Lactate is an abundant oncometabolite in the tumor environment. In prostate cancer, cancer-associated fibroblasts (CAF) are major contributors of secreted…”
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Integrating radiation therapy with targeted treatments for breast cancer: From bench to bedside by Meattini, Icro, Livi, Lorenzo, Lorito, Nicla, Becherini, Carlotta, Bacci, Marina, Visani, Luca, Fozza, Alessandra, Belgioia, Liliana, Loi, Mauro, Mangoni, Monica, Lambertini, Matteo, Morandi, Andrea

“…•Breast cancer therapeutic landscape has significantly evolved with an array of targeted therapies.•Pivotal trials of new drugs did not include quality…”
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Lactate supports cell-autonomous ECM production to sustain metastatic behavior in prostate cancer by Ippolito, Luigi, Duatti, Assia, Iozzo, Marta, Comito, Giuseppina, Pardella, Elisa, Lorito, Nicla, Bacci, Marina, Pranzini, Erica, Santi, Alice, Sandrini, Giada, Catapano, Carlo V, Serni, Sergio, Spatafora, Pietro, Morandi, Andrea, Giannoni, Elisa, Chiarugi, Paola

“…Extracellular matrix (ECM) is a major component of the tumor environment, promoting the establishment of a pro-invasive behavior. Such environment is supported…”
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Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer by De Santis, Maria Chiara, Gozzelino, Luca, Margaria, Jean Piero, Costamagna, Andrea, Ratto, Edoardo, Gulluni, Federico, Di Gregorio, Enza, Mina, Erica, Lorito, Nicla, Bacci, Marina, Lattanzio, Rossano, Sala, Gianluca, Cappello, Paola, Novelli, Francesco, Giovannetti, Elisa, Vicentini, Caterina, Andreani, Silvia, Delfino, Pietro, Corbo, Vincenzo, Scarpa, Aldo, Porporato, Paolo Ettore, Morandi, Andrea, Hirsch, Emilio, Martini, Miriam

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with limited therapeutic options. However, metabolic adaptation to the harsh PDAC environment…”
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Acetyl-CoA carboxylase 1 controls a lipid droplet-peroxisome axis and is a vulnerability of endocrine-resistant ER + breast cancer by Bacci, Marina, Lorito, Nicla, Smiriglia, Alfredo, Subbiani, Angela, Bonechi, Francesca, Comito, Giuseppina, Morriset, Ludivine, El Botty, Rania, Benelli, Matteo, López-Velazco, Joanna I, Caffarel, Maria M, Urruticoechea, Ander, Sflomos, George, Malorni, Luca, Corsini, Michela, Ippolito, Luigi, Giannoni, Elisa, Meattini, Icro, Matafora, Vittoria, Havas, Kristina, Bachi, Angela, Chiarugi, Paola, Marangoni, Elisabetta, Morandi, Andrea

“…Targeting aromatase deprives ER breast cancers of estrogens and is an effective therapeutic approach for these tumors. However, drug resistance is an unmet…”
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The STAT3 Inhibitor Galiellalactone Reduces IL6-Mediated AR Activity in Benign and Malignant Prostate Models by Handle, Florian, Puhr, Martin, Schaefer, Georg, Lorito, Nicla, Hoefer, Julia, Gruber, Martina, Guggenberger, Fabian, Santer, Frédéric R, Marques, Rute B, van Weerden, Wytske M, Claessens, Frank, Erb, Holger H H, Culig, Zoran

“…IL6/STAT3 signaling is associated with endocrine therapy resistance in prostate cancer, but therapies targeting this pathway in prostate cancer were…”
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Abstract 1787: The β3-adrenergic receptor as novel target of metabolic phenotype in Ewing sarcoma by Banella, Cristina, Carrozzo, Francesco, Zocca, Laura, Pasha, Amada, Mattei, Gianluca, Mola, Marina, Ballerini, Lara, Lorito, Nicla, Tondo, Annalisa, Favre, Claudio, Calvani, Maura

“…Abstract Purpose of study: Metabolic targeted therapies may represent an innovative strategy in Ewing sarcoma (ES). Introduction: Ewing sarcoma (ES) is highly…”
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