Search Results - "Loriot, M.A"

Long‐Term Clinical Impact of Adaptation of Initial Tacrolimus Dosing to CYP3A5 Genotype by Pallet, N., Etienne, I., Buchler, M., Bailly, E., Hurault de Ligny, B., Choukroun, G., Colosio, C., Thierry, A., Vigneau, C., Moulin, B., Le Meur, Y., Heng, A.‐E., Legendre, C., Beaune, P., Loriot, M. A., Thervet, E.

“…Pretransplantation adaptation of the daily dose of tacrolimus to CYP3A5 genotype is associated with improved achievement of target trough concentration (C0),…”
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Kidney Transplant Recipients Carrying the CYP3A422 Allelic Variant Have Reduced Tacrolimus Clearance and Often Reach Supratherapeutic Tacrolimus Concentrations by Pallet, N., Jannot, A.‐S., El Bahri, M., Etienne, I., Buchler, M., de Ligny, B. H., Choukroun, G., Colosio, C., Thierry, A., Vigneau, C., Moulin, B., Le Meur, Y., Heng, A.‐E., Subra, J.‐F., Legendre, C., Beaune, P., Alberti, C., Loriot, M. A., Thervet, E.

“…CYP3A4*22 is an allelic variant of the cytochrome P450 3A4 associated with a decreased activity. Carriers of this polymorphism may require reduced tacrolimus…”
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[OP.6D.05] INFLUENCE OF MULTIDRUG RESISTANCE P-GLYCOPROTEIN GENE POLYMORPHISM OR INHBITION ON PLASMA ALDOSTERONE CONCENTRATION IN HEALTHY SUBJECTS by Dubourg, J, Blanchard, A, Zhygalina, V, Gouin Thibault, I, Salem, J.E, Funck-brentano, C, Landau Loriot, M.A, Azizi, M

“…OBJECTIVE:The multidrug resistance P-glycoprotein (P-gp) has been shown to contribute to the secretion of aldosterone by human adrenal cells in vitro. To…”
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Predictive Modeling of Tacrolimus Dose Requirement Based on High‐Throughput Genetic Screening by Damon, C., Luck, M., Toullec, L., Etienne, I., Buchler, M., Hurault de Ligny, B., Choukroun, G., Thierry, A., Vigneau, C., Moulin, B., Heng, A.‐E., Subra, J.‐F., Legendre, C., Monnot, A., Yartseva, A., Bateson, M., Laurent‐Puig, P., Anglicheau, D., Beaune, P., Loriot, M. A., Thervet, E., Pallet, N.

“…Any biochemical reaction underlying drug metabolism depends on individual gene–drug interactions and on groups of genes interacting together. Based on a…”
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NMR metabolomic of frontal cortex extracts: First study comparing two neurodegenerative diseases, Alzheimer disease and amyotrophic lateral sclerosis by Botosoa, E.P, Zhu, M, Marbeuf-Gueye, C, Triba, M.N, Dutheil, F, Duyckäerts, C, Beaune, P, Loriot, M.A, Le Moyec, L

“…Abstract Objective This study was designed to assess the brain metabolites’ variability between two neurodegenerative diseases in frontal cortex samples…”
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S.28.02 Brain localization of cytochrome P450 by Loriot, M.A, Dutheil, F, Flinois, J.P, Duyckaerts, C, Beaune, P.H

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Effect of different genetics variants: CYP2C92, CYP2C93 of cytochrome P-450 CYP2C9 and 1639G>A of the VKORC1 gene; On acenocoumarol requirement in Moroccan patients by Smires, F.Z., Habbal, R., Moreau, C., Assaidi, A., Loriot, M.A., Nadifi, S.

“…Coumarin derivatives such as acenocoumarol represent the therapy of choice for the long-term treatment and prevention of thromboembolic diseases. Many genetics…”
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P-191 Exploration of the implication of thymidylate synthase polymorphisms on the risk of colorectal cancer in west Algerian population by Aberkane, M., Loriot, M.A.

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Interindividual variability in dabigatran and rivaroxaban exposure: contribution of ABCB1 genetic polymorphisms and interaction with clarithromycin by Gouin‐Thibault, I., Delavenne, X., Blanchard, A., Siguret, V., Salem, J. E., Narjoz, C., Gaussem, P., Beaune, P., Funck‐Brentano, C., Azizi, M., Mismetti, P., Loriot, M. A.

“…Essentials Rivaroxaban and dabigatran are substrates of the P‐glycoprotein (P‐gp) encoded by the ABCB1 gene. We tested the effect of ABCB1 polymorphisms and of…”
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16 Glutathione S-transferase activity-genotype association with time and severity of Pseudomonas aeruginosa lung infection in cystic fibrosis children by Feuillet-Fieux, M.N, Nguyen-Khoa, T, Kebede, M, Loriot, M.A, Verrier, P, De Villartay, P, Beaune, P, Lenoir, G, Lacour, B

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3018 POSTER Pharmacogenetic analysis of toxicity after 5-fluorouracil (5FU) or 5FU/Oxaliplatin therapy for metastatic colorectal cancer: Preliminary results in FFCD 2000–05 trial by Boige, V, Castaing, M, Loriot, M.A, Barrois, M, Miran, I, Mulot, C, Pignon, J.P, Ducreux, M, Laurent-Puig, P

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Development and validation of a UPLC-UV method for the quantification of thiopurine methyltransferase enzyme activity in human erythrocytes by Illamola, S.M., Echaabi, A.K., Mazeron, C., Deshayes, S., Loriot, M.A., Pallet, N.

“…Thiopurines are drugs widely used for the treatment of autoimmune conditions, inflammatory bowel disease or acute lymphoblastic leukemia. Determination of…”
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Caractéristiques cliniques, biochimiques et épidémiologiques d’une macro-ASAT précédant le diagnostic de maladie inflammatoire chronique de l’intestin de plusieurs années by Nadour, Z., Rosenbaum, B., Blons, H., Loriot, M.A., Paul, J.-L., Pallet, N.

“…Une élévation isolée de l’aspartate aminotransférase (ASAT) est un problème diagnostique. La macro-aspartate aminotransférase (macro-ASAT) correspond à la…”
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Multiple genetic alterations in vitamin K epoxide reductase complex subunit 1 gene (VKORC1) can explain the high dose requirement during oral anticoagulation in humans by BODIN, L., PERDU, J., DIRY, M., HORELLOU, M.‐H., LORIOT, M.‐A.

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Characterisation of novel defective thiopurine S-methyltransferase allelic variants by Garat, A., Cauffiez, C., Renault, N., Lo-Guidice, J.M., Allorge, D., Chevalier, D., Houdret, N., Chavatte, P., Loriot, M.A., Gala, J.L., Broly, F.

“…Human thiopurine S-methyltransferase (TPMT, EC 2.1.1.67) is a key enzyme in the detoxification of thiopurine drugs widely used in the treatment of various…”
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Genetic resistance to warfarin therapy masked by amiodarone in a 2‐year‐old girl with mitral valve replacement by Moreau, C., Bajolle, F., Siguret, V., Loriot, M.‐A., Bonnet, D.

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A vitamin K epoxide reductase complex subunit‐1 (VKORC1) mutation in a patient with vitamin K antagonist resistance by BODIN, L., HORELLOU, M. H., FLAUJAC, C., LORIOT, M. A., SAMAMA, M. M.

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P101 Effect of different genetic variants (2C92, 2C93 of cytochrome P-450 CYP2C9 and −1639G>A of the VKORC1 gene) on acenocoumarol requirement in Moroccan patients by Smires, F.-Z., Assaidi, A., Loriot, M.A., Moreau, C., Habbal, R., Nadifi, S.

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P101 Poster Effect of different genetic variants (2C92, 2C93 of cytochrome P-450 CYP2C9 and −1639G>A of the VKORC1 gene) on acenocoumarol requirement in Moroccan patients by Smires, F.-Z., Assaidi, A., Loriot, M.A., Moreau, C., Habbal, R., Nadifi, S.

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Impact de l’acide mycophénolique sur la reprogrammation métabolique des cellules T by Fernandez Ramos, A.A., Laurent-Marchetti, C., Poindessous, V., Antonio, S., Laurent-Puig, P., Bortoli, S., Loriot, M.A., Pallet, N.

“…La reprogrammation métabolique permet à la fois la prolifération rapide et la différenciation des cellules T au cours de l’activation lymphocytaire. Cette…”
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