Performance of the OraQuick HCV rapid antibody test for screening exposed patients in a hepatitis C outbreak investigation

During a nosocomial hepatitis C outbreak, emergency public clinics employed the OraQuick HCV rapid antibody test on site, and all results were verified by a standard enzyme immunoassay (EIA). Of 1,157 persons, 1,149 (99.3%) exhibited concordant results between the two tests (16 positive, 1,133 negat...

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Bibliographic Details
Published in:	Journal of clinical microbiology Vol. 52; no. 7; pp. 2650 - 2652
Main Authors:	Gao, Fengxiang, Talbot, Elizabeth A, Loring, Carol H, Power, Jill J, Dionne-Odom, Jodie, Alroy-Preis, Sharon, Jackson, Patricia, Bean, Christine L
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 01-07-2014
Subjects:	Clinical Laboratory Techniques - methods Cross Infection - diagnosis Cross Infection - epidemiology Disease Outbreaks Female Hepatitis C - diagnosis Hepatitis C - epidemiology Hepatitis C Antibodies - blood Hepatitis C virus Humans Male Mass Screening - methods Predictive Value of Tests Sensitivity and Specificity Virology
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Summary:	During a nosocomial hepatitis C outbreak, emergency public clinics employed the OraQuick HCV rapid antibody test on site, and all results were verified by a standard enzyme immunoassay (EIA). Of 1,157 persons, 1,149 (99.3%) exhibited concordant results between the two tests (16 positive, 1,133 negative). The sensitivity, specificity, positive predictive value, and negative predictive value were 94.1%, 99.5%, 72.7%, and 99.9%, respectively. OraQuick performed well as a screening test during an outbreak investigation and could be integrated into future hepatitis C virus (HCV) outbreak testing algorithms.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0095-1137 1098-660X
DOI:	10.1128/JCM.00132-14