Search Results - "Lorimer, Ellen"

An adenosine-mediated signaling pathway suppresses prenylation of the GTPase Rap1B and promotes cell scattering by Ntantie, Elizabeth, Gonyo, Patrick, Lorimer, Ellen L, Hauser, Andrew D, Schuld, Nathan, McAllister, Donna, Kalyanaraman, Balaraman, Dwinell, Michael B, Auchampach, John A, Williams, Carol L

“…During metastasis, cancer cells acquire the ability to dissociate from each other and migrate, which is recapitulated in vitro as cell scattering. The small…”
Get more information

Splice switching an oncogenic ratio of SmgGDS isoforms as a strategy to diminish malignancy by Brandt, Anthony C., McNally, Lisa, Lorimer, Ellen L., Unger, Bethany, Koehn, Olivia J., Suazo, Kiall F., Rein, Lisa, Szabo, Aniko, Tsaih, Shirng-Wern, Distefano, Mark D., Flister, Michael J., Rigo, Frank, McNally, Mark T., Williams, Carol L.

“…The chaperone protein SmgGDS promotes cell-cycle progression and tumorigenesis in human breast and nonsmall cell lung cancer. Splice variants of SmgGDS, named…”
Get full text

Synthesis, Enzymatic Peptide Incorporation, and Applications of Diazirine-Containing Isoprenoid Diphosphate Analogues by Justyna, Katarzyna, Das, Riki, Lorimer, Ellen L., Hu, Jiayue, Pedersen, Jodi S., Sprague-Getsy, Andrea M., Schey, Garrett L., Sieburg, Michelle A., Koehn, Olivia J., Wang, Yen-Chih, Chen, Yong-Xiang, Hougland, James L., Williams, Carol L., Distefano, Mark D.

“…Prenylated proteins contain C15 or C20 isoprenoids linked to cysteine residues positioned near their C-termini. Here we describe the preparation of isoprenoid…”
Get full text

Differences in the Phosphorylation-Dependent Regulation of Prenylation of Rap1A and Rap1B by Wilson, Jessica M., Prokop, Jeremy W., Lorimer, Ellen, Ntantie, Elizabeth, Williams, Carol L.

“…Two isoforms of the small GTPase Rap1, Rap1A and Rap1B, participate in cell adhesion; Rap1A promotes steady state adhesion, while Rap1B regulates dynamic…”
Get full text

The role of Rac1 in the regulation of NF-κB activity, cell proliferation, and cell migration in non-small cell lung carcinoma by Gastonguay, Adam, Berg, Tracy, Hauser, Andrew D, Schuld, Nathan, Lorimer, Ellen, Williams, Carol L

“…The small GTPase Rac1 regulates many cellular processes, including cytoskeletal reorganization, cell migration, proliferation, and survival. Additionally, Rac1…”
Get full text

Splice Variants of SmgGDS Control Small GTPase Prenylation and Membrane Localization by Berg, Tracy J., Gastonguay, Adam J., Lorimer, Ellen L., Kuhnmuench, John R., Li, Rongshan, Fields, Alan P., Williams, Carol L.

“…Ras and Rho small GTPases possessing a C-terminal polybasic region (PBR) are vital signaling proteins whose misregulation can lead to cancer. Signaling by…”
Get full text

The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases by Bergom, Carmen, Hauser, Andrew D., Rymaszewski, Amy, Gonyo, Patrick, Prokop, Jeremy W., Jennings, Benjamin C., Lawton, Alexis J., Frei, Anne, Lorimer, Ellen L., Aguilera-Barrantes, Irene, Mackinnon, Alexander C., Noon, Kathleen, Fierke, Carol A., Williams, Carol L.

“…The small GTPase DiRas1 has tumor-suppressive activities, unlike the oncogenic properties more common to small GTPases such as K-Ras and RhoA. Although DiRas1…”
Get full text

SmgGDS-558 regulates the cell cycle in pancreatic, non-small cell lung, and breast cancers by Schuld, Nathan, Hauser, Andrew, Gastonguay, Adam, Wilson, Jessica, Lorimer, Ellen, Williams, Carol

“…Oncogenic mutation or misregulation of small GTPases in the Ras and Rho families can promote unregulated cell cycle progression in cancer. Post-translational…”
Get full text

The Chaperone Protein SmgGDS Interacts with Small GTPases Entering the Prenylation Pathway by Recognizing the Last Amino Acid in the CAAX Motif by Schuld, Nathan J., Vervacke, Jeffrey S., Lorimer, Ellen L., Simon, Nathan C., Hauser, Andrew D., Barbieri, Joseph T., Distefano, Mark D., Williams, Carol L.

“…Ras family small GTPases localize at the plasma membrane, where they can activate oncogenic signaling pathways. Understanding the mechanisms that promote…”
Get full text

The SmgGDS splice variant SmgGDS-558 is a key promoter of tumor growth and RhoA signaling in breast cancer by Hauser, Andrew D, Bergom, Carmen, Schuld, Nathan J, Chen, Xiuxu, Lorimer, Ellen L, Huang, Jian, Mackinnon, Alexander C, Williams, Carol L

“…Breast cancer malignancy is promoted by the small GTPases RhoA and RhoC. SmgGDS is a guanine nucleotide exchange factor that activates RhoA and RhoC in vitro…”
Get full text

Rap1A, Rap1B, and β-Adrenergic Signaling in Autologous HCT: A Randomized Controlled Trial of Propranolol by Johnson, Alexander K, Lorimer, Ellen L, Szabo, Aniko, Wu, Ruizhe, Shah, Nirav N, D'Souza, Anita, Chhabra, Saurabh, Hamadani, Mehdi, Dhakal, Binod, Hari, Parameswaran, Rao, Sridhar, Carlson, Karen, Williams, Carol L, Knight, Jennifer M

“…Successful hematopoietic cell transplantation (HCT) depends on rapid engraftment of the progenitor and stem cells that will reestablish hematopoiesis. Rap1A…”
Get full text

SmgGDS Regulates Cell Proliferation, Migration, and NF-κB Transcriptional Activity in Non-small Cell Lung Carcinoma by Tew, Gaik Wei, Lorimer, Ellen L., Berg, Tracy J., Zhi, Huiying, Li, Rongshan, Williams, Carol L.

“…Non-small cell lung carcinoma (NSCLC) is promoted by the increased activities of several small GTPases, including K-Ras4B, Rap1A, Rap1B, RhoC, and Rac1. SmgGDS…”
Get full text

The tumor-suppressive small GTPase DiRas1 binds the noncanonical guanine nucleotide exchange factor SmgGDS and antagonizes SmgGDS interactions with oncogenic small GTPases by Bergom, Carmen, Hauser, Andrew D., Rymaszewski, Amy, Gonyo, Patrick, Prokop, Jeremy W., Jennings, Benjamin C., Lawton, Alexis J., Frei, Anne, Lorimer, Ellen L., Aguilera-Barrantes, Irene, Mackinnon, Alexander C., Noon, Kathleen, Fierke, Carol A., Williams, Carol L.

Get full text

The role of Rac1 in the regulation of NF-kB activity, cell proliferation, and cell migration in non-small cell lung carcinoma by Gastonguay, Adam, Berg, Tracy, Hauser, Andrew D., Schuld, Nathan, Lorimer, Ellen, Williams, Carol L.

“…The small GTPase Rac1 regulates many cellular processes, including cytoskeletal reorganization, cell migration, proliferation, and survival. Additionally, Rac1…”
Get full text

Structural and biophysical properties of farnesylated KRas interacting with the chaperone SmgGDS-558 by Michalak, Dennis J., Unger, Bethany, Lorimer, Ellen, Grishaev, Alexander, Williams, Carol L., Heinrich, Frank, Lösche, Mathias

“…KRas is a small GTPase and membrane-bound signaling protein. Newly synthesized KRas is post-translationally modified with a membrane-anchoring prenyl group…”
Get full text

Interactions of the GDP Dissociation Stimulator Smggds with Kras: X-Ray Scattering and Rosetta Docking Studies and Differences in Interaction of Two Isoforms with Membrane-Bound Kras4B by Michalak, Dennis J., Lorimer, Ellen, Unger, Bethany, Williams, Carol L., Heinrich, Frank, Lösche, Mathias

Get full text

β-Adrenergic receptors suppress Rap1B prenylation and promote the metastatic phenotype in breast cancer cells by Wilson, Jessica M, Lorimer, Ellen, Tyburski, Michael D, Williams, Carol L

“…A greater understanding of the molecular basis of breast cancer metastasis will lead to identification of novel therapeutic targets and better treatments…”
Get full text

GTPase splice variants RAC1 and RAC1B display isoform-specific differences in localization, prenylation, and interaction with the chaperone protein SmgGDS by Koehn, Olivia J., Lorimer, Ellen, Unger, Bethany, Harris, Ra’Mal, Das, Akansha S., Suazo, Kiall F., Auger, Shelby A., Distefano, Mark D., Prokop, Jeremy W., Williams, Carol L.

“…Identifying events that regulate the prenylation and localization of small GTPases will help define new strategies for therapeutic targeting of these proteins…”
Get full text

Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer by Nissim, Sahar, Leshchiner, Ignaty, Mancias, Joseph D., Greenblatt, Matthew B., Maertens, Ophélia, Cassa, Christopher A., Rosenfeld, Jill A., Cox, Andrew G., Hedgepeth, John, Wucherpfennig, Julia I., Kim, Andrew J., Henderson, Jake E., Gonyo, Patrick, Brandt, Anthony, Lorimer, Ellen, Unger, Bethany, Prokop, Jeremy W., Heidel, Jerry R., Wang, Xiao-Xu, Ukaegbu, Chinedu I., Jennings, Benjamin C., Paulo, Joao A., Gableske, Sebastian, Fierke, Carol A., Getz, Gad, Sunyaev, Shamil R., Wade Harper, J., Cichowski, Karen, Kimmelman, Alec C., Houvras, Yariv, Syngal, Sapna, Williams, Carol, Goessling, Wolfram

“…Pancreatic ductal adenocarcinoma is an aggressive cancer with limited treatment options 1 . Approximately 10% of cases exhibit familial predisposition, but…”
Get full text

New Insights into the Role of SmgGDS as a Major Integrator of Signaling by Ras and Rho Family Members in Cancer by Williams, Carol, Gonyo, Patrick, Brandt, Anthony, Koehn, Olivia, Lorimer, Ellen, Unger, Bethany, Tsaih, Shirng‐Wern, Sun, Yunguang, McNally, Mark, Rui, Hallgeir, Flister, Michael, Bergom, Carmen

“…Small GTPases in the Ras and Rho families are major participants in the signaling cascades that promote malignancy. Defining how these signaling cascades are…”
Get full text