Search Results - "Lories, Rik"

Innovation in Targeted Intra-articular Therapies for Osteoarthritis by Assi, Reem, Quintiens, Jolien, Monteagudo, Silvia, Lories, Rik J.

“…Osteoarthritis is the most common chronic joint disease characterized by progressive damage to the joints, leading to pain and loss of function. There is…”
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Targets, models and challenges in osteoarthritis research by Thysen, Sarah, Luyten, Frank P, Lories, Rik J U

“…Osteoarthritis is a chronic degenerative disorder of the joint and represents one of the most common diseases worldwide. Its prevalence and severity are…”
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The balance of tissue repair and remodeling in chronic arthritis by Lories, Rik

“…Targeted therapies for chronic joint diseases are now able to control many of the disease symptoms—the research focus has now shifted towards the structural…”
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Ankylosing spondylitis: an autoimmune or autoinflammatory disease? by Mauro, Daniele, Thomas, Ranjeny, Guggino, Giuliana, Lories, Rik, Brown, Matthew A., Ciccia, Francesco

“…Ankylosing spondylitis (AS) is a chronic inflammatory disorder of unknown aetiology. Unlike other systemic autoimmune diseases, in AS, the innate immune system…”
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DOT1L safeguards cartilage homeostasis and protects against osteoarthritis by Monteagudo, Silvia, Cornelis, Frederique M. F., Aznar-Lopez, Carolina, Yibmantasiri, Ploi, Guns, Laura-An, Carmeliet, Peter, Cailotto, Frédéric, Lories, Rik J.

“…Osteoarthritis is the most prevalent and crippling joint disease, and lacks curative treatment, as the underlying molecular basis is unclear. Here, we show…”
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Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis by Gracey, Eric, Burssens, Arne, Cambré, Isabelle, Schett, Georg, Lories, Rik, McInnes, Iain B., Asahara, Hiroshi, Elewaut, Dirk

“…Mechanical loading is an important factor in musculoskeletal health and disease. Tendons and ligaments require physiological levels of mechanical loading to…”
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Cushioning the cartilage: a canonical Wnt restricting matter by Monteagudo, Silvia, Lories, Rik J.

“…Key Points Wnt signalling is essential for joint health: loss of and excessive activation of the canonical signalling pathway are both deleterious for…”
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Enthesitis: from pathophysiology to treatment by Schett, Georg, Lories, Rik J., D'Agostino, Maria-Antonietta, Elewaut, Dirk, Kirkham, Bruce, Soriano, Enrique R., McGonagle, Dennis

“…Key Points Entheses are predominantly extra-articularly localized structures that represent a key target of musculoskeletal inflammation in diseases such as…”
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The bone-cartilage unit in osteoarthritis by Lories, Rik J, Luyten, Frank P

“…Osteoarthritis (OA) is a disease of the whole joint, at the centre of which lies the interface between cartilage and bone. Altered transfer of mechanical…”
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Advances in understanding the pathophysiology of spondyloarthritis by Lories, Rik J.

“…Progressive understanding of the underlying pathophysiology of axial spondyloarthritis has successfully translated into innovative therapeutic strategies and…”
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Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells by Jacques, Peggy, Lambrecht, Stijn, Verheugen, Eveline, Pauwels, Elin, Kollias, George, Armaka, Maria, Verhoye, Marleen, Van der Linden, Annemie, Achten, Rik, Lories, Rik J, Elewaut, Dirk

“…Spondyloarthritides (SpA) are characterised by both peripheral and axial arthritis. The hallmarks of peripheral SpA are the development of enthesitis, most…”
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Progress in spondylarthritis. Mechanisms of new bone formation in spondyloarthritis by Lories, Rik J U, Luyten, Frank P, de Vlam, Kurt

“…Targeted therapies that neutralize tumour necrosis factor are often able to control the signs and symptoms of spondyloarthritis. However, recent animal model…”
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To Wnt or not to Wnt: the bone and joint health dilemma by Lories, Rik J., Corr, Maripat, Lane, Nancy E.

“…Wnt signalling has important roles in bone development, growth and homeostasis. Herein, the authors review our current understanding of Wnt signalling in…”
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Quantification of lung fibrosis and emphysema in mice using automated micro-computed tomography by De Langhe, Ellen, Vande Velde, Greetje, Hostens, Jeroen, Himmelreich, Uwe, Nemery, Benoit, Luyten, Frank P, Vanoirbeek, Jeroen, Lories, Rik J

“…In vivo high-resolution micro-computed tomography allows for longitudinal image-based measurements in animal models of lung disease. The combination of…”
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Inhibition of KDM7A/B histone demethylases restores H3K79 methylation and protects against osteoarthritis by Assi, Reem, Cherifi, Chahrazad, Cornelis, Frederique M F, Zhou, Qiongfei, Storms, Lies, Pazmino, Sofia, Coutinho de Almeida, Rodrigo, Meulenbelt, Ingrid, Lories, Rik J, Monteagudo, Silvia

“…In osteoarthritis, methylation of lysine 79 on histone H3 (H3K79me), a protective epigenetic mechanism, is reduced. Histone methylation levels are dynamically…”
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Promising targets for therapy of osteoarthritis: a review on the Wnt and TGF-β signalling pathways by Cherifi, Chahrazad, Monteagudo, Silvia, Lories, Rik J.

“…Osteoarthritis (OA) is the most common chronic joint disorder worldwide, with a high personal burden for the patients and an important socio-economic impact…”
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Review Article: Is Wnt Signaling an Attractive Target for the Treatment of Osteoarthritis? by Lories, Rik J., Monteagudo, Silvia

“…Osteoarthritis is the most common chronic joint disease affecting millions of people worldwide and a leading cause of pain and disability. Increasing incidence…”
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A Notch in the joint that exacerbates osteoarthritis by Monteagudo, Silvia, Lories, Rik J.

“…Tight regulation of signalling cascades is vital for the correct development and function of bones and joints. A new study suggests that Notch signalling might…”
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Pathophysiology of New Bone Formation and Ankylosis in Spondyloarthritis by Lories, Rik J.U., MD, PhD, Schett, Georg, MD

“…The outcome of patients suffering from spondyloarthritis is determined by chronic inflammation and new bone formation leading to ankylosis. The latter process…”
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Evolving concepts of new bone formation in axial spondyloarthritis: Insights from animal models and human studies by Lories, Rik J., Haroon, Nigil

“…New bone formation potentially leading to ankylosis of the sacroiliac joints and the spine is the main type of structural damage to the skeleton that…”
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