Search Results - "Lorenzo Luaces, Patricia"

Pharmacokinetic Evaluation of Nimotuzumab in Patients With Autosomal Dominant Polycystic Kidney Disease by Castro‐Suárez, Niurys, Rodríguez‐Vera, Leyanis, Villegas, Carlos, Dávalos‐Iglesias, José M., Bacallao‐Mendez, Raymed, Llerena‐Ferrer, Betsy, Leyva‐de la Torre, Christian, Lorenzo‐ Luaces, Patricia, Troche‐Concepción, Mayelin, Ramos‐Suzarte, Mayra

“…Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disease characterized by an overexpression and mislocalization of epidermal growth factor…”
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Radiotherapy plus nimotuzumab or placebo in the treatment of high grade glioma patients: results from a randomized, double blind trial by Solomón, Maria Teresa, Selva, Julio César, Figueredo, Javier, Vaquer, José, Toledo, Carolina, Quintanal, Nelson, Salva, Silvia, Domíngez, Rafael, Alert, José, Marinello, Jorge Juan, Catalá, Mauricio, Griego, Martha González, Martell, Juan Antonio, Luaces, Patricia Lorenzo, Ballesteros, Javier, de-Castro, Niurys, Bach, Ferdinand, Crombet, Tania

“…The prognosis of patients bearing high grade glioma remains dismal. Epidermal Growth Factor Receptor (EGFR) is well validated as a primary contributor of…”
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Identifying predictive biomarkers of CIMAvaxEGF success in non-small cell lung cancer patients by Lorenzo-Luaces, Patricia, Sanchez, Lizet, Saavedra, Danay, Crombet, Tania, Van der Elst, Wim, Alonso, Ariel, Molenberghs, Geert, Lage, Agustin

“…Immunosenescence biomarkers and peripheral blood parameters are evaluated separately as possible predictive markers of immunotherapy. Here, we illustrate the…”
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Assessment of non-classical lymphocyte populations in patients with advanced lung cancer treated with Biomodulina T following platinum-based chemotherapy by Suárez, Gisela María, Catalá, Mauricio, Peña, Yadira, Portela, Susana, Añé-Kourí, Ana Laura, González, Amnely, Lorenzo-Luaces, Patricia, Díaz, Manuel, Molina, María de los A., Pereira, Karla, Hernández, Jenysbel de la C., Reyes, Mary Carmen, Ledón, Nuris, Mazorra, Zaima, Crombet, Tania, Lage, Agustin, Bencomo-Hernandez, Antonio, Saavedra, Danay

“…Aim: Currently, malignant diseases represent a health issue worldwide. Among these, lung cancer is of growing importance, due to its high incidence and…”
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Thymic Polypeptide Fraction Biomodulina T Decreases Exhausted and Terminally Differentiated EMRA T Cells in Advanced Lung Cancer Patients Treated With Platinum-Based Chemotherapy by Suárez, Gisela María, Catalá, Mauricio, Peña, Yadira, Portela, Susana, Añé-Kourí, Ana Laura, González, Amnely, Lorenzo-Luaces, Patricia, Díaz, Manuel, Molina, María de Los A, Pereira, Karla, Hernández, Jenysbel de la C, Ramos, Raúl, Reyes, Mary Carmen, Ledón, Nuris, Mazorra, Zaima, Crombet, Tania, Lage, Agustin, Saavedra, Danay

“…Lung cancer is the second cause of cancer related deaths worldwide. Chemotherapy and immunotherapy represent the current standard of care for advanced NSCLC…”
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Treatment of malignant, non-resectable, epithelial origin esophageal tumours with the humanized anti-epidermal growth factor antibody nimotuzumab combined with radiation therapy and chemotherapy by Ramos-Suzarte, Mayra, Lorenzo-Luaces, Patricia, Lazo, Nery Gonzalez, Perez, Mayte Lima, Soriano, Jorge Luis, Gonzalez, Carmen Elena Viada, Hernadez, Ivis Mendoza, Albuerne, Yisel Ávila, Moreno, Beatriz Paredes, Alvarez, Eduardo Santiesteban, Callejo, Idael Pineda, Alert, Jose, Martell, Juan Antonio, Gonzalez, Yanela Santiesteban, Gonzalez, Yulainis Santiesteban, Astudillo de la Vega, Horacio, Ruiz-Garcia, Erika Betzabe, Ramos, Tania Crombet

“…Background: Over-expression of epidermal growth factor receptor in esophageal cancer is associated with poor prognosis. The present study was conducted to…”
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Nimotuzumab Increases the Recovery Rate of Severe and Critical COVID-19 Patients: Evaluation in the Real-World Scenario by Diaz, Henrry, Jiménez, Jorge, Hernández, Aray, Valdés, Leivis, Martínez, Ariadna, Porto, Leonor, Hernández, Raity, Travieso, Nadina, Jova, Julio Héctor, Medel, Loipa, Troche, Mayelin, Gorte, Annia, Batista, Delmis, Valls, Ana Rosa, Cabrera, Leticia, Domeq, Milagros, Pérez, Leslie, Lorenzo-Luaces, Patricia, Sánchez, Lizet, Saavedra, Danay, Ramos, Mayra, Crombet, Tania

“…EGFR signaling is an important regulator of SARS-CoV induced lung damage, inflammation and fibrosis. Nimotuzumab is a humanized anti-EGFR antibody registered…”
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Safety and Immunogenicity of a Human Epidermal Growth Factor Receptor 1 (HER1)-Based Vaccine in Prostate Castration-Resistant Carcinoma Patients: A Dose-Escalation Phase I Study Trial by Caballero, Iraida, Aira, Lazaro E, Lavastida, Anabel, Popa, Xitlally, Rivero, Javier, González, Joaquín, Mesa, Mónica, González, Narjara, Coba, Kelly, Lorenzo-Luaces, Patricia, Wilkinson, Barbara, Santiesteban, Yuliannis, Santiesteban, Yanela, Troche, Mayelin, Suarez, Eduardo, Crombet, Tania, Sánchez, Belinda, Casacó, Angel, Macías, Amparo, Mazorra, Zaima

“…Metastatic castration-resistant prostate cancer (CRPC) remains incurable due to the lack of effective therapies. Activation of the human epidermal growth…”
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Treatment of children with high grade glioma with nimotuzumab: a 5-year institutional experience by Cabanas, Ricardo, Saurez, Giselle, Rios, Martha, Alert, Jose, Reyes, Adnolys, Valdes, Jose, Gonzalez, Maria C, Pedrayes, Jorge L, Avila, Melba, Herrera, Raiza, Infante, Mariela, Echevarria, Ernesto, Moreno, Myrna, Luaces, Patricia Lorenzo, Ramos, Tania Crombet

“…Brain tumors are a major cause of cancer-related mortality in children. Overexpression of epidermal growth factor receptor (EGFR) is detected in pediatric…”
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Prolonged use of nimotuzumab in children with central nervous system tumors: safety and feasibility by Cabanas, Ricardo, Saurez, Giselle, Alert, Jose, Reyes, Adnolys, Valdes, Jose, Gonzalez, Maria Caridad, Pedrayes, Jorge Luis, Valle, Luis, Infante, Mariela, Avila, Melba, Herrera, Raisa, Hechavarria, Ernesto, Rios, Marta, Fernández, Aymara, Lorenzo Luaces, Patricia, Crombet Ramos, Tania

“…Primary brain tumors constitute the most frequent solid tumor of childhood. High expression of the epidermal growth factor receptor (EGFR) protein has been…”
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PREVAX: A Phase I Clinical Trial of an EGF-Based Vaccine in Moderate-to-Severe COPD Patients by Hernandez Reyes, Jenysbel de la C, Santos Morales, Orestes, Hernandez Moreno, Laura, Pino Alfonso, Pedro Pablo, Neninger Vinageras, Elia, Knigths Montalvo, Julia Lilliam, Aguilar Sosa, Aliuska, Gonzalez Morera, Amnely, Lorenzo-Luaces Alvárez, Patricia, Aguilar Venegas, Yadira, Troche Concepción, Mayelin, Medel Pérez, Loipa, Santiesteban González, Yanela, García Fernández, Lázara, Regueiro Rodríguez, Lorena, Macías Abrahan, Amparo, Labrada Mon, Mayrel, León Monzón, Kalet, Saavedra Hernández, Danay, Crombet Ramos, Tania

“…EGFR has been suggested to contribute to COPD development and progression. Excessive ligand activation of the receptor leads to epithelial hyperproliferation…”
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Spatial analysis of breast and cervical cancer incidence in small geographical areas in Cuba, 1999-2003 by Alvarez, Patricia Lorenzo-Luaces, Guerra-Yi, Marta E., Faes, Christel, Alvarez, Yaima Galán, Molenberghs, Geert

“…According to the data from the National Cancer Registry, breast and cervical cancer are the two most common nonskin cancers in Cuban woman. This study was…”
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Marcadores de inmunosenescencia y su relación con el cáncer de pulmón by Saavedra Hernández, Danay, García Verdecia, Beatriz, González Morera, Amnely, Lorenzo-Luaces Álvarez, Patricia, Lage Dávila, Agustín

“…RESUMEN Introducción: Los cambios en el sistema inmune relacionados con la edad se han denominado inmunosenescencia. Objetivos: investigar el efecto de la edad…”
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Reposicionamiento del anticuerpo monoclonal humanizado cubano nimotuzumab en el tratamiento de pacientes con COVID-19 by Díaz Londres, Henrry, Jiménez Armada, Jorge, Hernández Martínez, Aray, Abdo Cuza, Anselmo A., Hernández Sánchez, Yamilka, Granado Rodríguez, Aylin, Sepúlveda Figueroa, Sarahy, Llanez Gregorich, Egda M., Torres Lahera, Mery L., Gómez Peire, Francisco, Montero González, Teresita, Zamora González, Yaneth, Añé Kouri, Ana L., González Palomo, Addys, Troche Concepción, Mayelin, Medel Pérez, Loipa, Luaces Alvarez, Patricia Lorenzo, Estévez Iglesias, Daymys, Saavedra Hernández, Danay, Ramos Suzarte, Mayra, Crombet Ramos, Tania

“…RESUMEN Introducción: La lesión pulmonar y el déficit del transductor de señal y el activador de la transcripción 1 (STAT1) inducen la sobreexpresión de…”
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A Phase III Clinical Trial of the Epidermal Growth Factor Vaccine CIMAvax-EGF as Switch Maintenance Therapy in Advanced Non-Small Cell Lung Cancer Patients by Rodriguez, Pedro C, Popa, Xitllaly, Martínez, Odeth, Mendoza, Silvia, Santiesteban, Eduardo, Crespo, Tatiana, Amador, Rosa M, Fleytas, Ricardo, Acosta, Soraida C, Otero, Yanine, Romero, Gala N, de la Torre, Ana, Cala, Mireysi, Arzuaga, Lina, Vello, Loisel, Reyes, Delmairis, Futiel, Niurka, Sabates, Teresa, Catala, Mauricio, Flores, Yoanna I, Garcia, Beatriz, Viada, Carmen, Lorenzo-Luaces, Patricia, Marrero, Maria A, Alonso, Liuba, Parra, Jenelin, Aguilera, Nadia, Pomares, Yaisel, Sierra, Patricia, Rodríguez, Gryssell, Mazorra, Zaima, Lage, Agustin, Crombet, Tania, Neninger, Elia

“…EGFR is a well-validated target for patients with non-small cell lung cancer (NSCLC). CIMAvax-EGF is a therapeutic cancer vaccine composed of human recombinant…”
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Final results from a phase II trial of CIMAvax-EGF and nivolumab as second-line (2L) therapy after platinum-based chemotherapy in advanced non-small cell lung cancer (NSCLC) by Frascati, Rachel, Early, Amy P., Reid, Mary E., Lee, Kelvin, Muhitch, Jason, Mesa, Circe, Luaces, Patricia Lorenzo, Santos-Morales, Orestes, Dozier, Askia, Puzanov, Igor, Fountzilas, Christos, Gandhi, Shipra, Attwood, Kristopher, Hutson, Alan, Johnson, Candace S., Herrera, Zaima, Saavedra, Danay, Leon, Kalet, Crombet Ramos, Tania, Dy, Grace K.

“…9135 Background: CIMAvax-EGF (C-E) is a recombinant anti-human epidermal growth factor (EGF) depleting immunotherapy which has previously shown increased…”
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Immunosenescence and inflammatory markers in Cuban centenarians: implications for survival by Ledón, Nuris, Añé-Kourí, Ana Laura, Ramos, Mercedes Bárbara, Lorenzo-Luaces, Patricia, Silva, Alexa, Pereira, Karla, Lage, Agustin, Saavedra, Danay

“…Centenarians are the best example of successful aging in humans. This work aimed to understand if immune status is associated with survival in Cuban…”
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Biomarkers related to immunosenescence: relationships with therapy and survival in lung cancer patients by Saavedra, Danay, García, Beatriz, Lorenzo-Luaces, Patricia, González, Amnely, Popa, Xitlally, Fuentes, Karla P., Mazorra, Zaima, Crombet, Tania, Neninger, Elia, Lage, Agustin

“…Purpose There are well-known alterations occurring within the immune system with aging. Collectively, these changes are known as immunosenescence. The…”
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Association among Terminally Differentiated T Cells, Frailty, and Dependency in a Group of Cuban Centenarians by Añé-Kourí, Ana Laura, Ledón, Nuris, Ramos, Mercedes Bárbara, González, Amnely, Pereira, Karla, Rodríguez, Marbelys, Vidal, Alejandro, Rodríguez, Yamile, Bicet, Yamile de la Caridad, Llanez-Gregorich, Egda, Lorenzo-Luaces, Patricia, Suárez, Gisela María, Silva, Alexa, Crombet, Tania, Saavedra, Danay, Lage, Agustin

“…Centenarians are considered a model of successful aging. Cuba exhibits one of the oldest populations in Latin America with more than two thousand centenarians…”
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Biomodulina T partially restores immunosenescent CD4 and CD8 T cell compartments in the elderly by Saavedra, Danay, Fuertes, Silvia A., Suárez, Gisela M., González, Amnely, Lorenzo-Luaces, Patricia, García, Beatriz, Aznar, Elisa, Mazorra, Zaima, Crombet, Tania, Speiser, Daniel E., Lage, Agustin

“…The changes that occur in the immune system with aging are commonly termed immunosenescence. Immunosenescence affects almost all components and functions of…”
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