Search Results - "Lorenzo Giacani"

Strategies for syphilis vaccine development by Giacani, Lorenzo

“…Research to identify a syphilis vaccine began shortly after the isolation of the first Treponema pallidum subspecies pallidum (T. pallidum) strain in 1912 by…”
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The Endemic Treponematoses by GIACANI, Lorenzo, LUKEHART, Sheila A

“…Classifications Services CMR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Genetic engineering of Treponema pallidum subsp. pallidum, the Syphilis Spirochete by Romeis, Emily, Tantalo, Lauren, Lieberman, Nicole, Phung, Quynh, Greninger, Alex, Giacani, Lorenzo

“…Despite more than a century of research, genetic manipulation of Treponema pallidum subsp. pallidum ( T . pallidum ), the causative agent of syphilis, has not…”
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Treponema pallidum subsp. pallidum with an Artificially impaired TprK antigenic variation system is attenuated in the Rabbit model of syphilis by Romeis, Emily, Lieberman, Nicole A P, Molini, Barbara, Tantalo, Lauren C, Chung, Benjamin, Phung, Quynh, Avendaño, Carlos, Vorobieva, Anastassia, Greninger, Alexander L, Giacani, Lorenzo

“…The TprK protein of the syphilis agent, Treponema pallidum subsp. pallidum (T. pallidum), undergoes antigenic variation in seven discrete variable (V) regions…”
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Analysis of host cell binding specificity mediated by the Tp0136 adhesin of the syphilis agent Treponema pallidum subsp. pallidum by Djokic, Vitomir, Giacani, Lorenzo, Parveen, Nikhat

“…Syphilis affects approximately 11 million people each year globally, and is the third most prevalent sexually transmitted bacterial infection in the United…”
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Identification and Functional Assessment of the First Placental Adhesin of Treponema pallidum That May Play Critical Role in Congenital Syphilis by Primus, Shekerah, Rocha, Sandra C, Giacani, Lorenzo, Parveen, Nikhat

“…Syphilis is a global, re-emerging sexually transmitted infection and congenital syphilis remains a major cause of adverse pregnancy outcomes due to bacterial…”
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The wide utility of rabbits as models of human diseases by Esteves, Pedro J., Abrantes, Joana, Baldauf, Hanna-Mari, BenMohamed, Lbachir, Chen, Yuxing, Christensen, Neil, González-Gallego, Javier, Giacani, Lorenzo, Hu, Jiafen, Kaplan, Gilla, Keppler, Oliver T., Knight, Katherine L., Kong, Xiang-Peng, Lanning, Dennis K., Le Pendu, Jacques, de Matos, Ana Lemos, Liu, Jia, Liu, Shuying, Lopes, Ana M., Lu, Shan, Lukehart, Sheila, Manabe, Yukari C., Neves, Fabiana, McFadden, Grant, Pan, Ruimin, Peng, Xuwen, de Sousa-Pereira, Patricia, Pinheiro, Ana, Rahman, Masmudur, Ruvoën-Clouet, Natalie, Subbian, Selvakumar, Tuñón, Maria Jesús, van der Loo, Wessel, Vaine, Michael, Via, Laura E., Wang, Shixia, Mage, Rose

“…Studies using the European rabbit Oryctolagus cuniculus contributed to elucidating numerous fundamental aspects of antibody structure and diversification…”
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B-Cell Epitope Mapping of TprC and TprD Variants of Treponema pallidum Subspecies Informs Vaccine Development for Human Treponematoses by Molini, Barbara, Fernandez, Mark C, Godornes, Charmie, Vorobieva, Anastassia, Lukehart, Sheila A, Giacani, Lorenzo

“…Several recent studies have focused on the identification, functional analysis, and structural characterization of outer membrane proteins (OMPs) of ( ). The…”
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Treponema pallidum subsp. pallidum TP0136 protein is heterogeneous among isolates and binds cellular and plasma fibronectin via its NH2-terminal end by Ke, Wujian, Molini, Barbara J, Lukehart, Sheila A, Giacani, Lorenzo

“…Adherence-mediated colonization plays an important role in pathogenesis of microbial infections, particularly those caused by extracellular pathogens…”
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Transcriptional and immunological analysis of the putative outer membrane protein and vaccine candidate TprL of Treponema pallidum by Haynes, Austin M, Fernandez, Mark, Romeis, Emily, Mitjà, Oriol, Konda, Kelika A, Vargas, Silver K, Eguiluz, Maria, Caceres, Carlos F, Klausner, Jeffrey D, Giacani, Lorenzo

“…An effective syphilis vaccine should elicit antibodies to Treponema pallidum subsp. pallidum (T. p. pallidum) surface antigens to induce pathogen clearance…”
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Development of a Multilocus Sequence Typing (MLST) scheme for Treponema pallidum subsp. pertenue: Application to yaws in Lihir Island, Papua New Guinea by Godornes, Charmie, Giacani, Lorenzo, Barry, Alyssa E, Mitja, Oriol, Lukehart, Sheila A

“…Yaws is a neglected tropical disease, caused by Treponema pallidum subsp. pertenue. The disease causes chronic lesions, primarily in young children living in…”
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Longitudinal TprK profiling of in vivo and in vitro-propagated Treponema pallidum subsp. pallidum reveals accumulation of antigenic variants in absence of immune pressure by Lin, Michelle J, Haynes, Austin M, Addetia, Amin, Lieberman, Nicole A P, Phung, Quynh, Xie, Hong, Nguyen, Tien V, Molini, Barbara J, Lukehart, Sheila A, Giacani, Lorenzo, Greninger, Alexander L

“…Immune evasion by Treponema pallidum subspecies pallidum (T. pallidum) has been attributed to antigenic variation of its putative outer-membrane protein TprK…”
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Ulcerative skin lesions among children in Cameroon: It is not always Yaws by Ndzomo Ngono, Jean-Philippe, Tchatchouang, Serges, Noah Tsanga, Mireille Victorine, Njih Tabah, Earnest, Tchualeu, Albert, Asiedu, Kingsley, Giacani, Lorenzo, Eyangoh, Sara, Crucitti, Tania

“…Outbreaks of yaws-like ulcerative skin lesions in children are frequently reported in tropical and sub-tropical countries. The origin of these lesions might be…”
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Transcription of TP0126, Treponema pallidum putative OmpW homolog, is regulated by the length of a homopolymeric guanosine repeat by Giacani, Lorenzo, Brandt, Stephanie L, Ke, Wujian, Reid, Tara B, Molini, Barbara J, Iverson-Cabral, Stefanie, Ciccarese, Giulia, Drago, Francesco, Lukehart, Sheila A, Centurion-Lara, Arturo

“…An effective mechanism for introduction of phenotypic diversity within a bacterial population exploits changes in the length of repetitive DNA elements located…”
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Fine analysis of genetic diversity of the tpr gene family among treponemal species, subspecies and strains by Centurion-Lara, Arturo, Giacani, Lorenzo, Godornes, Charmie, Molini, Barbara J, Brinck Reid, Tara, Lukehart, Sheila A

“…The pathogenic non-cultivable treponemes include three subspecies of Treponema pallidum (pallidum, pertenue, endemicum), T. carateum, T. paraluiscuniculi, and…”
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Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster by Arora, Natasha, Schuenemann, Verena J., Jäger, Günter, Peltzer, Alexander, Seitz, Alexander, Herbig, Alexander, Strouhal, Michal, Grillová, Linda, Sánchez-Busó, Leonor, Kühnert, Denise, Bos, Kirsten I., Davis, Leyla Rivero, Mikalová, Lenka, Bruisten, Sylvia, Komericki, Peter, French, Patrick, Grant, Paul R., Pando, María A., Vaulet, Lucía Gallo, Fermepin, Marcelo Rodríguez, Martinez, Antonio, Centurion Lara, Arturo, Giacani, Lorenzo, Norris, Steven J., Šmajs, David, Bosshard, Philipp P., González-Candelas, Fernando, Nieselt, Kay, Krause, Johannes, Bagheri, Homayoun C.

“…The abrupt onslaught of the syphilis pandemic that started in the late fifteenth century established this devastating infectious disease as one of the most…”
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Directly Sequenced Genomes of Contemporary Strains of Syphilis Reveal Recombination-Driven Diversity in Genes Encoding Predicted Surface-Exposed Antigens by Grillová, Linda, Oppelt, Jan, Mikalová, Lenka, Nováková, Markéta, Giacani, Lorenzo, Niesnerová, Anežka, Noda, Angel A, Mechaly, Ariel E, Pospíšilová, Petra, Čejková, Darina, Grange, Philippe A, Dupin, Nicolas, Strnadel, Radim, Chen, Marcus, Denham, Ian, Arora, Natasha, Picardeau, Mathieu, Weston, Christopher, Forsyth, R Allyn, Šmajs, David

“…Syphilis, caused by subsp. (TPA), remains an important public health problem with an increasing worldwide prevalence. Despite recent advances in cultivation,…”
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Efficacy of linezolid on Treponema pallidum, the syphilis agent: A preclinical study by Haynes, Austin M., Giacani, Lorenzo, Mayans, Marti Vall, Ubals, Maria, Nieto, Carles, Pérez-Mañá, Clara, Quintó, Llorenç, Romeis, Emily, Mitjà, Oriol

“…Penicillin G, the current standard treatment for syphilis, has important drawbacks, but virtually no preclinical or clinical studies have been performed to…”
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Sequencing of Treponema pallidum subsp. pallidum from isolate UZ1974 using Anti-Treponemal Antibodies Enrichment: First complete whole genome sequence obtained directly from human clinical material by Grillová, Linda, Giacani, Lorenzo, Mikalová, Lenka, Strouhal, Michal, Strnadel, Radim, Marra, Christina, Centurion-Lara, Arturo, Poveda, Lucy, Russo, Giancarlo, Čejková, Darina, Vašků, Vladimír, Oppelt, Jan, Šmajs, David

“…Treponema pallidum subsp. pallidum (TPA) is the infectious agent of syphilis, a disease that infects more than 5 million people annually. Since TPA is an…”
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Comparative Investigation of the Genomic Regions Involved in Antigenic Variation of the TprK Antigen among Treponemal Species, Subspecies, and Strains by Giacani, Lorenzo, Brandt, Stephanie L, Puray-Chavez, Maritza, Reid, Tara Brinck, Godornes, Charmie, Molini, Barbara J, Benzler, Martin, Hartig, Jörg S, Lukehart, Sheila A, Centurion-Lara, Arturo

“…Although the three Treponema pallidum subspecies (T. pallidum subsp. pallidum, T. pallidum subsp. pertenue, and T. pallidum subsp. endemicum), Treponema…”
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