Search Results - "Lorenzo Bozzelli, P."

Proteolytic Remodeling of Perineuronal Nets: Effects on Synaptic Plasticity and Neuronal Population Dynamics by Villapol, Sonia, Kim, Eunyoung, Alaiyed, Seham, Lorenzo Bozzelli, P., Conant, Katherine

“…The perineuronal net (PNN) represents a lattice-like structure that is prominently expressed along the soma and proximal dendrites of parvalbumin- (PV-)…”
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Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity by Victor, Matheus B., Leary, Noelle, Luna, Xochitl, Meharena, Hiruy S., Scannail, Aine Ni, Bozzelli, P. Lorenzo, Samaan, George, Murdock, Mitchell H., von Maydell, Djuna, Effenberger, Audrey H., Cerit, Oyku, Wen, Hsin-Lan, Liu, Liwang, Welch, Gwyneth, Bonner, Maeve, Tsai, Li-Huei

“…Apolipoprotein E4 (APOE4) is the greatest known genetic risk factor for developing sporadic Alzheimer’s disease. How the interaction of APOE4 microglia with…”
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Inhibitory Parvalbumin Basket Cell Activity is Selectively Reduced during Hippocampal Sharp Wave Ripples in a Mouse Model of Familial Alzheimer's Disease by Caccavano, Adam, Bozzelli, P Lorenzo, Forcelli, Patrick A, Pak, Daniel T S, Wu, Jian-Young, Conant, Katherine, Vicini, Stefano

“…Memory disruption in mild cognitive impairment (MCI) and Alzheimer's disease (AD) is poorly understood, particularly at early stages preceding…”
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Venlafaxine stimulates PNN proteolysis and MMP‐9‐dependent enhancement of gamma power; relevance to antidepressant efficacy by Alaiyed, Seham, Bozzelli, P. Lorenzo, Caccavano, Adam, Wu, Jian Young, Conant, Katherine

“…Drugs that target monoaminergic transmission represent a first‐line treatment for major depression. Though a full understanding of the mechanisms that underlie…”
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HIV‐1 Tat promotes astrocytic release of CCL2 through MMP/PAR‐1 signaling by Bozzelli, P. Lorenzo, Yin, Tao, Avdoshina, Valeria, Mocchetti, Italo, Conant, Katherine E., Maguire‐Zeiss, Kathleen A.

“…The HIV‐1 protein Tat is continually released by HIV‐infected cells despite effective combination antiretroviral therapies (cART). Tat promotes neurotoxicity…”
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Increased matrix metalloproteinase levels and perineuronal net proteolysis in the HIV-infected brain; relevance to altered neuronal population dynamics by Bozzelli, P. Lorenzo, Caccavano, Adam, Avdoshina, Valeria, Mocchetti, Italo, Wu, Jian-Young, Conant, Katherine

“…HIV-associated neurocognitive disorders (HAND) continue to persist despite effective control of viral replication. Although the mechanisms underlying HAND are…”
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Multisensory gamma stimulation mitigates the effects of demyelination induced by cuprizone in male mice by Rodrigues-Amorim, Daniela, Bozzelli, P. Lorenzo, Kim, TaeHyun, Liu, Liwang, Gibson, Oliver, Yang, Cheng-Yi, Murdock, Mitchell H., Galiana-Melendez, Fabiola, Schatz, Brooke, Davison, Alexis, Islam, Md Rezaul, Shin Park, Dong, Raju, Ravikiran M., Abdurrob, Fatema, Nelson, Alissa J., Min Ren, Jian, Yang, Vicky, Stokes, Matthew P., Tsai, Li-Huei

“…Demyelination is a common pathological feature in a wide range of diseases, characterized by the loss of myelin sheath and myelin-supporting oligodendrocytes…”
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Matrix metalloproteinase activity stimulates N-cadherin shedding and the soluble N-cadherin ectodomain promotes classical microglial activation by Conant, Katherine, Daniele, Stefano, Bozzelli, P Lorenzo, Abdi, Tsion, Edwards, Amanda, Szklarczyk, Arek, Olchefske, India, Ottenheimer, David, Maguire-Zeiss, Kathleen

“…Matrix metalloproteinases (MMPs) are a family of enzymes that are typically released from intracellular stores to act on specific extracellular substrates. MMP…”
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Spatial memory deficits in a mouse model of late-onset Alzheimer's disease are caused by zinc supplementation and correlate with amyloid-beta levels by Flinn, Jane M, Bozzelli, P Lorenzo, Adlard, Paul A, Railey, Angela M

“…Much of the research in Alzheimer's disease (AD) that uses mouse models focuses on the early-onset form of the disease, which accounts for less than 5% of…”
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3177 Determining mechanisms underlying hippocampal network disruption in early amyloid pathology by Caccavano, Adam, Bozzelli, P. Lorenzo, Conant, Katherine, Vicini, Stefano

“…OBJECTIVES/SPECIFIC AIMS: Alzheimer’s disease (AD) is the leading cause of dementia, and a rapidly growing public health crisis as life expectancy increases…”
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Treating insomnia with 40 Hz light flicker by Bozzelli, P. Lorenzo, Tsai, Li-Huei

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MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration by Barker, Scarlett J, Raju, Ravikiran M, Milman, Noah E P, Wang, Jun, Davila-Velderrain, Jose, Gunter-Rahman, Fatima, Parro, Cameron C, Bozzelli, P Lorenzo, Abdurrob, Fatema, Abdelaal, Karim, Bennett, David A, Kellis, Manolis, Tsai, Li-Huei

“…Recent increases in human longevity have been accompanied by a rise in the incidence of dementia, highlighting the need to preserve cognitive function in an…”
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Alterations in a cross-hemispheric circuit associates with novelty discrimination deficits in mouse models of neurodegeneration by Adaikkan, Chinnakkaruppan, Wang, Jun, Abdelaal, Karim, Middleton, Steven J., Bozzelli, P. Lorenzo, Wickersham, Ian R., McHugh, Thomas J., Tsai, Li-Huei

“…A major pathological hallmark of neurodegenerative diseases, including Alzheimer’s, is a significant reduction in the white matter connecting the two cerebral…”
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Disruption of perineuronal nets increases the frequency of sharp wave ripple events by Sun, Zhi Yong, Bozzelli, P. Lorenzo, Caccavano, Adam, Allen, Megan, Balmuth, Jason, Vicini, Stefano, Wu, Jian‐Young, Conant, Katherine

“…Hippocampal sharp wave ripples (SWRs) represent irregularly occurring synchronous neuronal population events that are observed during phases of rest and slow…”
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Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration by Welch, Gwyneth M, Boix, Carles A, Schmauch, Eloi, Davila-Velderrain, Jose, Victor, Matheus B, Dileep, Vishnu, Bozzelli, P Lorenzo, Su, Qiao, Cheng, Jemmie D, Lee, Audrey, Leary, Noelle S, Pfenning, Andreas R, Kellis, Manolis, Tsai, Li-Huei

“…DNA double-strand breaks (DSBs) are linked to neurodegeneration and senescence. However, it is not clear how DSB-bearing neurons influence neuroinflammation…”
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Human ApoE ε4 alters circadian rhythm activity, IL-1β, and GFAP in CRND8 mice by Graybeal, John J, Bozzelli, P Lorenzo, Graybeal, Lacey L, Groeber, Caitlin M, McKnight, Patrick E, Cox, Daniel N, Flinn, Jane M

“…Disruptions to daily living, inflammation, and astrogliosis are characteristics of Alzheimer's disease. Thus, circadian rhythms, nest construction, IL-1β and…”
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Electroconvulsive Shock Enhances Responsive Motility and Purinergic Currents in Microglia in the Mouse Hippocampus by Sepulveda-Rodriguez, Alberto, Li, Pinggan, Khan, Tahiyana, Ma, James D, Carlone, Colby A, Bozzelli, P Lorenzo, Conant, Katherine E, Forcelli, Patrick A, Vicini, Stefano

“…Microglia are in a privileged position to both affect and be affected by neuroinflammation, neuronal activity and injury, which are all hallmarks of seizures…”
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Spatial memory deficits in a mouse model of late-onset Alzheimer’s disease are caused by zinc supplementation and correlate with amyloid-beta levels by Flinn, Jane M., Bozzelli, P. Lorenzo, Adlard, Paul A., Railey, Angela M.

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