Search Results - "Lorenzo, Petra Isabel"
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A Simple High Efficiency Intra-Islet Transduction Protocol Using Lentiviral Vectors
Published in Current gene therapy (01-01-2015)“…Successful normalization of blood glucose in patients transplanted with pancreatic islets isolated from cadaveric donors established the proof-of-concept that…”
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Levothyroxine enhances glucose clearance and blunts the onset of experimental type 1 diabetes mellitus in mice
Published in British journal of pharmacology (01-11-2017)“…Background and Purpose Thyroid hormones induce several changes in whole body metabolism that are known to improve metabolic homeostasis. However, adverse side…”
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PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus
Published in Diabetologia (01-04-2016)“…Aims/hypothesis A strategy to enhance pancreatic islet functional beta cell mass (BCM) while restraining inflammation, through the manipulation of molecular…”
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Inhibition of Apoptosis in Prostate Cancer Cells by Androgens Is Mediated through Downregulation of c-Jun N-terminal Kinase Activation
Published in Neoplasia (New York, N.Y.) (01-05-2008)“…Androgen deprivation induces the regression of prostate tumors mainly due to an increase in the apoptosis rate; however, the molecular mechanisms underlying…”
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Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging
Published in Aging (Albany, NY.) (13-09-2019)“…An inverse correlation between thyroid hormone levels and longevity has been reported in several species and reduced thyroid hormone levels have been proposed…”
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SUMO-regulated activation function controls synergy of c-Myb through a repressor-activator switch leading to differential p300 recruitment
Published in Nucleic acids research (01-08-2010)“…Synergy between transcription factors operating together on complex promoters is a key aspect of gene activation. The ability of specific factors to synergize…”
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Thyroid hormones in diabetes, cancer, and aging
Published in Aging cell (01-11-2020)“…Thyroid hormones are central in the control of health and disease. Here we review the latest findings in thyroid hormone research in the field of diabetes,…”
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Inhibition of Apoptosis in Prostate Cancer Cells by Androgens Is Mediated through Downregulation of c-Jun N-terminal Kinase Activation1
Published in Neoplasia (New York, N.Y.) (01-05-2008)“…Androgen deprivation induces the regression of prostate tumors mainly due to an increase in the apoptosis rate; however, the molecular mechanisms underlying…”
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Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells
Published in Disease models & mechanisms (01-03-2014)“…Human kidney predominant protein, NCU-G1, is a highly conserved protein with an unknown biological function. Initially described as a nuclear protein, it was…”
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Identification of c-Myb Target Genes in K562 Cells Reveals a Role for c-Myb as a Master Regulator
Published in Genes & cancer (01-08-2011)“…The c-Myb transcription factor is an important regulator of hematopoietic cell development. c-Myb is expressed in immature hematopoietic cells and plays a…”
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Thyroid Hormone‐Regulated Expression of RC3/Neurogranin in the Immortalized Hypothalamic Cell Line GT1‐7
Published in Journal of neurochemistry (01-09-1997)“…: The calmodulin‐binding, protein kinase C substrate RC3/neurogranin is the product of a neuron‐specific gene expressed in the forebrain that is under specific…”
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