Search Results - "Lorenzo, Melvin F"

High-Frequency Irreversible Electroporation for Treatment of Primary Liver Cancer: A Proof-of-Principle Study in Canine Hepatocellular Carcinoma by Partridge, Brittanie R., O’Brien, Timothy J., Lorenzo, Melvin F., Coutermarsh-Ott, Sheryl L., Barry, Sabrina L., Stadler, Krystina, Muro, Noelle, Meyerhoeffer, Mitchell, Allen, Irving C., Davalos, Rafael V., Dervisis, Nikolaos G.

“…To determine the safety and feasibility of percutaneous high-frequency irreversible electroporation (HFIRE) for primary liver cancer and evaluate the…”
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Establishing an immunocompromised porcine model of human cancer for novel therapy development with pancreatic adenocarcinoma and irreversible electroporation by Hendricks-Wenger, Alissa, Aycock, Kenneth N., Nagai-Singer, Margaret A., Coutermarsh-Ott, Sheryl, Lorenzo, Melvin F., Gannon, Jessica, Uh, Kyungjun, Farrell, Kayla, Beitel-White, Natalie, Brock, Rebecca M., Simon, Alexander, Morrison, Holly A., Tuohy, Joanne, Clark-Deener, Sherrie, Vlaisavljevich, Eli, Davalos, Rafael V., Lee, Kiho, Allen, Irving C.

“…New therapies to treat pancreatic cancer are direly needed. However, efficacious interventions lack a strong preclinical model that can recapitulate patients’…”
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High-frequency irreversible electroporation improves survival and immune cell infiltration in rodents with malignant gliomas by Campelo, Sabrina N, Lorenzo, Melvin F, Partridge, Brittanie, Alinezhadbalalami, Nastaran, Kani, Yukitaka, Garcia, Josefa, Saunier, Sofie, Thomas, Sean C, Hinckley, Jonathan, Verbridge, Scott S, Davalos, Rafael V, Rossmeisl, Jr, John H

“…Irreversible electroporation (IRE) has been previously investigated in preclinical trials as a treatment for intracranial malignancies. Here, we investigate…”
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Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy by O'Brien, Timothy J., Lorenzo, Melvin F., Zhao, Yajun, Neal II, Robert E., Robertson, John L., Goldberg, S. Nahum, Davalos, Rafael V.

“…Purpose: This study evaluates the effects of various pulsing paradigms, on the irreversible electroporation (IRE) lesion, induced electric current, and…”
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An Investigation for Large Volume, Focal Blood-Brain Barrier Disruption with High-Frequency Pulsed Electric Fields by Lorenzo, Melvin F, Campelo, Sabrina N, Arroyo, Julio P, Aycock, Kenneth N, Hinckley, Jonathan, Arena, Christopher B, Rossmeisl, Jr, John H, Davalos, Rafael V

“…The treatment of CNS disorders suffers from the inability to deliver large therapeutic agents to the brain parenchyma due to protection from the blood-brain…”
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Patient Derived Xenografts Expand Human Primary Pancreatic Tumor Tissue Availability for ex vivo Irreversible Electroporation Testing by Brock, Rebecca M., Beitel-White, Natalie, Coutermarsh-Ott, Sheryl, Grider, Douglas J., Lorenzo, Melvin F., Ringel-Scaia, Veronica M., Manuchehrabadi, Navid, Martin, Robert C. G., Davalos, Rafael V., Allen, Irving C.

“…New methods of tumor ablation have shown exciting efficacy in pre-clinical models but often demonstrate limited success in the clinic. Due to a lack of quality…”
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Advancements in drug delivery methods for the treatment of brain disease by Partridge, Brittanie, Eardley, Allison, Morales, Brianna E, Campelo, Sabrina N, Lorenzo, Melvin F, Mehta, Jason N, Kani, Yukitaka, Mora, Josefa K Garcia, Campbell, Etse-Oghena Y, Arena, Christopher B, Platt, Simon, Mintz, Akiva, Shinn, Richard L, Rylander, Christopher G, Debinski, Waldemar, Davalos, Rafael V, Rossmeisl, John H

“…The blood-brain barrier (BBB) presents a formidable obstacle to the effective delivery of systemically administered pharmacological agents to the brain, with…”
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Investigation of High Frequency Irreversible Electroporation for Canine Spontaneous Primary Lung Tumor Ablation by Hay, Alayna N, Aycock, Kenneth N, Lorenzo, Melvin F, David, Kailee, Coutermarsh-Ott, Sheryl, Salameh, Zaid, Campelo, Sabrina N, Arroyo, Julio P, Ciepluch, Brittany, Daniel, Gregory, Davalos, Rafael V, Tuohy, Joanne

“…In this study, the feasibility of treating canine primary lung tumors with high-frequency irreversible electroporation (H-FIRE) was investigated as a novel…”
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High-Frequency Irreversible Electroporation (H-FIRE) Induced Blood-Brain Barrier Disruption Is Mediated by Cytoskeletal Remodeling and Changes in Tight Junction Protein Regulation by Partridge, Brittanie R, Kani, Yukitaka, Lorenzo, Melvin F, Campelo, Sabrina N, Allen, Irving C, Hinckley, Jonathan, Hsu, Fang-Chi, Verbridge, Scott S, Robertson, John L, Davalos, Rafael V, Rossmeisl, John H

“…Glioblastoma is the deadliest malignant brain tumor. Its location behind the blood-brain barrier (BBB) presents a therapeutic challenge by preventing effective…”
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A Theoretical Argument for Extended Interpulse Delays in Therapeutic High-Frequency Irreversible Electroporation Treatments by Aycock, Kenneth N., Zhao, Yajun, Lorenzo, Melvin F., Davalos, Rafael V.

“…High-frequency irreversible electroporation (H-FIRE) is a tissue ablation modality employing bursts of electrical pulses in a positive phase-interphase delay…”
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Rapid Impedance Spectroscopy for Monitoring Tissue Impedance, Temperature, and Treatment Outcome During Electroporation-Based Therapies by Lorenzo, Melvin F., Bhonsle, Suyashree P., Arena, Christopher B., Davalos, Rafael V.

“…Objective: Electroporation-based therapies (EBTs) employ high voltage pulsed electric fields (PEFs) to permeabilize tumor tissue; this results in changes in…”
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Characterization of Nonlinearity and Dispersion in Tissue Impedance During High-Frequency Electroporation by Bhonsle, Suyashree, Lorenzo, Melvin F., Safaai-Jazi, Ahmad, Davalos, Rafael V.

“…Objective: The use of high-voltage, high-frequency bipolar pulses (HFBPs) is an emerging electroporation-based therapy for the treatment of solid tumors. In…”
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Multi-Tissue Analysis on the Impact of Electroporation on Electrical and Thermal Properties by Beitel-White, Natalie, Lorenzo, Melvin F., Zhao, Yajun, Brock, Rebecca M., Coutermarsh-Ott, Sheryl, Allen, Irving C., Manuchehrabadi, Navid, Davalos, Rafael V.

“…Objective: Tissue electroporation is achieved by applying a series of electric pulses to destabilize cell membranes within the target tissue. The treatment…”
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High-frequency irreversible electroporation is an effective tumor ablation strategy that induces immunologic cell death and promotes systemic anti-tumor immunity by Ringel-Scaia, Veronica M., Beitel-White, Natalie, Lorenzo, Melvin F., Brock, Rebecca M., Huie, Kathleen E., Coutermarsh-Ott, Sheryl, Eden, Kristin, McDaniel, Dylan K., Verbridge, Scott S., Rossmeisl, John H., Oestreich, Kenneth J., Davalos, Rafael V., Allen, Irving C.

“…Despite promising treatments for breast cancer, mortality rates remain high and treatments for metastatic disease are limited. High-frequency irreversible…”
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Experimental High-Frequency Irreversible Electroporation Using a Single-Needle Delivery Approach for Nonthermal Pancreatic Ablation In Vivo by O’Brien, Timothy J., Passeri, Michael, Lorenzo, Melvin F., Sulzer, Jesse K., Lyman, William B., Swet, Jacob H., Vrochides, Dionisios, Baker, Erin H., Iannitti, David A., Davalos, Rafael V., McKillop, Iain H.

“…To investigate the feasibility of single-needle high-frequency irreversible electroporation (SN-HFIRE) to create reproducible tissue ablations in an in vivo…”
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Temporal Characterization of Blood-Brain Barrier Disruption with High-Frequency Electroporation by Lorenzo, Melvin F, Thomas, Sean C, Kani, Yukitaka, Hinckley, Jonathan, Lee, Matthew, Adler, Joy, Verbridge, Scott S, Hsu, Fang-Chi, Robertson, John L, Davalos, Rafael V, Rossmeisl, Jr, John H

“…Treatment of intracranial disorders suffers from the inability to accumulate therapeutic drug concentrations due to protection from the blood-brain barrier…”
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Irreversible electroporation for the ablation of pancreatic malignancies: A patient‐specific methodology by Latouche, Eduardo L., Sano, Michael B., Lorenzo, Melvin F., Davalos, Rafael V., Martin, Robert C. G.

“…Background and Objectives Irreversible Electroporation (IRE) is a focal ablation technique highly attractive to surgical oncologists due to its non‐thermal…”
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Extended interpulse delays improve therapeutic efficacy of microsecond-duration pulsed electric fields by Aycock, Kenneth N., Campelo, Sabrina N., Salameh, Zaid S., Vadlamani, Ram Anand, Lorenzo, Melvin F., Davalos, Rafael V.

“…Irreversible electroporation (IRE), or pulsed field ablation, employs microsecond-duration pulsed electric fields to generate targeted cellular damage without…”
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Properties of tissue within prostate tumors and treatment planning implications for ablation therapies by Beitel-White, Natalie, Aycock, Kenneth N, Manuchehrabadi, Navid, Zhao, Yajun, Imran, Khan Mohammad, Coutermarsh-Ott, Sheryl, Allen, Irving C, Lorenzo, Melvin F, Davalos, Rafael V

“…Irreversible electroporation (IRE) is a promising alternative therapy for the local treatment of prostate tumors. The procedure involves the direct insertion…”
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HIGH FREQUENCY IRREVERSIBLE ELECTROPORATION FOR TREATMENT OF PRIMARY LIVER CANCER - A PROOF OF PRINCIPAL STUDY IN CANINE HEPATOCELLULAR CARCINOMA by Partridge, Brittanie R., O’Brien, Timothy J., Lorenzo, Melvin F., Coutermarsh-Ott, Sheryl L., Barry, Sabrina L., Stadler, Krystina, Muro, Noelle, Meyerhoeffer, Mitchell, Allen, Irving C., Davalos, Rafael V., Dervisis, Nick G.

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