Search Results - "Loregian, A"

The Cytomegalovirus DNA Polymerase Subunit UL44 Forms a C Clamp-Shaped Dimer by Appleton, Brent A., Loregian, Arianna, Filman, David J., Coen, Donald M., Hogle, James M.

“…The human cytomegalovirus DNA polymerase consists of a catalytic subunit, UL54, and a presumed processivity factor, UL44. We have solved the crystal structure…”
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Disruption of the interactions between the subunits of herpesvirus DNA polymerases as a novel antiviral strategy by Loregian, A., Palù, G.

“…Most biological processes depend on the co-ordinated formation of protein–protein interactions. Besides their importance for virus replication, several…”
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P1910 Potential role of TDM in dosing protease inhibtors in HIV–HCV co–infected patients with or without cirrhosis by Gatti, F, Pagni, S, Nasta, P, Boldrin, C, Matti, A, Loregian, A, Biasi, L, Puoti, M, Parisi, S.G, Prestini, K, Palù, G, Carosi, G

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R2297 Pharmacokinetics of atazanavir in HIV-HCV co-infected patients with or without cirrhosis by Gatti, F, Loregian, A, Nasta, P, Pagni, S, Prestini, K, Matti, A, Parisi, S.G, Biasi, L, Puoti, M, Boldrin, C, Palŭ, G, Carosi, G

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Structure-Based Optimization of N‑Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant by Zhang, Jian, Murugan, Natarajan Arul, Tian, Ye, Bertagnin, Chiara, Fang, Zengjun, Kang, Dongwei, Kong, Xiujie, Jia, Haiyong, Sun, Zhuosen, Jia, Ruifang, Gao, Ping, Poongavanam, Vasanthanathan, Loregian, Arianna, Xu, Wenfang, Ma, Xiuli, Ding, Xiao, Huang, Bing, Zhan, Peng, Liu, Xinyong

“…Due to the emergence of highly pathogenic and oseltamivir-resistant influenza viruses, there is an urgent need to develop new anti-influenza agents. Herein,…”
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Disruption of protein-protein interactions: Towards new targets for chemotherapy by Loregian, Arianna, Palù, Giorgio

“…Protein–protein interactions play a key role in various mechanisms of cellular growth and differentiation, and in the replication of pathogen organisms in host…”
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Specific Inhibition of Herpes Virus Replication by Receptor-Mediated Entry of an Antiviral Peptide Linked to Escherichia coli Enterotoxin B Subunit by Marcello, Alessandro, Loregian, Arianna, Cross, Anne, Marsden, Howard, Hirst, Timothy R., Palu, Giorgio

“…Mimetic peptides capable of selectively disrupting protein-protein interactions represent potential therapeutic agents for inhibition of viral and cellular…”
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Quantitative analysis of ribonucleoside triphosphates in human lymphoid cells by micellar electrokinetic capillary chromatography by Bolzonella, C, Gusella, M, Bononi, A, Loregian, A, Crepaldi, G, Toso, S, Palù, G, Ferrazzi, E

“…Micellar electrokinetic capillary chromatography (MECC) was applied to develop an analytical method for quantitation of ribonucleoside triphosphates (rNTPs) in…”
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Identification and characterization of an extracellular protease activity produced by the marine Vibrio sp. 60 by Marcello, A, Loregian, A, De Filippis, V, Fontana, A, Hirst, T.R, Palu, G

“…The marine fish pathogen Vibrio sp. 60 has been used as a host for heterologous expression of the Escherichia coli heat-labile enterotoxin B-subunit and…”
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Effect of differential growth conditions on the dTTP pool size in herpes simplex virus-infected Vero cells by Marcello, A, Pizzato, M, Loregian, A, Palù, G

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Identification and characterization of an extracellular protease activity produced by the marine Vibriosp 60 by Marcello, A., Loregian, A., De Filippis, V., Fontana, A., Hirst, T.R., Palù, G.

“…Abstract The marine fish pathogen Vibrio sp. 60 has been used as a host for heterologous expression of the Escherichia coli heat-labile enterotoxin B-subunit…”
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Construction of a fusion protein between B subunit of E. coli heat-labile enterotoxin and the C-terminus of herpes simplex virus-DNA polymerase by Loregian, A, Marcello, A, Hirst, T R, Marsden, H S, Palu, G

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Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit. Differences in structure and function relative to unliganded UL44 by Appleton, Brent A, Brooks, Justin, Loregian, Arianna, Filman, David J, Coen, Donald M, Hogle, James M

“…The human cytomegalovirus DNA polymerase is composed of a catalytic subunit, UL54, and an accessory protein, UL44, which has a structural fold similar to that…”
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Residues of Human Cytomegalovirus DNA Polymerase Catalytic Subunit UL54 That Are Necessary and Sufficient for Interaction with the Accessory Protein UL44 by LOREGIAN, Arianna, APPLETON, Brent A, HOGLE, James M, COEN, Donald M

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Specific Residues in the Connector Loop of the Human Cytomegalovirus DNA Polymerase Accessory Protein UL44 Are Crucial for Interaction with the UL54 Catalytic Subunit by LOREGIAN, Arianna, APPLETON, Brent A, HOGLE, James M, COEN, Donald M

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Protein-protein interactions as targets for antiviral chemotherapy by Loregian, Arianna, Marsden, Howard S., Palù, Giorgio

“…Most cellular and viral processes depend on the coordinated formation of protein–protein interactions. With a better understanding of the molecular biology and…”
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Unboosted fosamprenavir is associated with low drug exposure in HIV-infected patients with mild–moderate liver impairment resulting from HCV-related cirrhosis by Gatti, Francesca, Nasta, Paola, Loregian, Arianna, Puoti, Massimo, Matti, Alessandro, Pagni, Silvana, de Requena, Daniel Gonzalez, Prestini, Katiela, Parisi, Saverio G., Bonora, Stefano, Palù, Giorgio, Carosi, Giampiero

“…Objectives The aim of this study was to compare amprenavir pharmacokinetics in HIV/hepatitis C virus (HCV)-co-infected cirrhotic patients receiving non-boosted…”
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Inhibition of Human Cytomegalovirus DNA Polymerase by C-Terminal Peptides from the UL54 Subunit by Loregian, Arianna, Rigatti, Roberto, Murphy, Mary, Schievano, Elisabetta, Palu, Giorgio, Marsden, Howard S

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Antiviral properties of new arylsulfone derivatives with activity against human betaherpesviruses by Naesens, Lieve, Stephens, Chad E., Andrei, Graciela, Loregian, Arianna, De Bolle, Leen, Snoeck, Robert, Sowell, J. Walter, De Clercq, Erik

“…Based on our previous experience with arylsulfone derivatives displaying antiherpetic activity, we synthesized several analogues in which the sulfonyl group is…”
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Interaction of Sp1 transcription factor with HIV-1 Tat protein: looking for cellular partners by Loregian, Arianna, Bortolozzo, Katia, Boso, Silvia, Caputo, Antonella, Palù, Giorgio

“…The Tat protein of human immunodeficiency virus type 1 (HIV-1) trans-activates HIV-1 transcription by functionally interacting with a number of cellular…”
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