Search Results - "Loredana Lupu"
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Michael Przybylski (1948–2023) Devoted Half a Century to Mass Spectrometry
Published in Journal of the American Society for Mass Spectrometry (06-09-2023)“…Michael Przybylski (1948–2023) was a Polymer Chemist by training and devoted nearly his entire scientific life, almost 50 years, to mass spectrometry and its…”
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Identification and Affinity Determination of Protein-Antibody and Protein-Aptamer Epitopes by Biosensor-Mass Spectrometry Combination
Published in International journal of molecular sciences (27-11-2021)“…Analytical methods for molecular characterization of diagnostic or therapeutic targets have recently gained high interest. This review summarizes the…”
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Antibody Epitope and Affinity Determination of the Myocardial Infarction Marker Myoglobin by SPR-Biosensor Mass Spectrometry
Published in Journal of the American Society for Mass Spectrometry (06-01-2021)“…Myoglobin (MG) is a biomarker for heart muscle injury, making it a potential target protein for early detection of myocardial infarction. Elevated myoglobin…”
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Unveiling the molecular mechanisms underpinning biorecognition of early-glycated human serum albumin and receptor for advanced glycation end products
Published in Analytical and bioanalytical chemistry (01-07-2020)“…Serum levels of early-glycated albumin are significantly increased in patients with diabetes mellitus and may play a role in worsening inflammatory status and…”
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Epitope characterization of proteins and aptamers with mass spectrometry
Published in European journal of mass spectrometry (Chichester, England) (01-12-2023)“…The way in which professor Michael Przybylski has combined the spirit of research with entrepreneurship has set an example for any and all scientists. He has…”
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Epitope Identification and Affinity Determination of an Inhibiting Human Antibody to Interleukin IL8 (CXCL8) by SPR- Biosensor–Mass Spectrometry Combination
Published in Journal of the American Society for Mass Spectrometry (02-01-2020)“…The polypeptide chemokine Interleukin-8 (IL8) plays a crucial role in inflammatory processes in humans. IL8 is involved in chronic inflammatory lung diseases,…”
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Epitope Ligand Binding Sites of Blood Group Oligosaccharides in Lectins Revealed by Pressure-Assisted Proteolytic Excision Affinity Mass Spectrometry
Published in Journal of the American Society for Mass Spectrometry (01-09-2018)“…Affinity mass spectrometry using selective proteolytic excision and extraction combined with MALDI and ESI mass spectrometry has been applied to the…”
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Epitope and affinity determination of recombinant Mycobacterium tuberculosis Ag85B antigen towards anti-Ag85 antibodies using proteolytic affinity-mass spectrometry and biosensor analysis
Published in Analytical and bioanalytical chemistry (01-01-2019)“…Tuberculosis (TB) is the first cause of death from infectious diseases worldwide. Only a single anti-TB vaccine is currently available for clinical use, but…”
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Molecular characterization of the [beta]-amyloid(4-10) epitope of plaque specific A[beta] antibodies by affinity-mass spectrometry using alanine site mutation
Published in Journal of peptide science (01-01-2018)“…Alzheimer disease is a neurodegenerative disease affecting an increasing number of patients worldwide. Current therapeutic strategies are directed to molecules…”
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Molecular characterization of the β‐amyloid(4‐10) epitope of plaque specific Aβ antibodies by affinity‐mass spectrometry using alanine site mutation
Published in Journal of peptide science (01-01-2018)“…Alzheimer disease is a neurodegenerative disease affecting an increasing number of patients worldwide. Current therapeutic strategies are directed to molecules…”
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Molecular Epitope Determination of Aptamer Complexes of the Multidomain Protein C‐Met by Proteolytic Affinity‐Mass Spectrometry
Published in ChemMedChem (17-02-2020)“…C‐Met protein is a glycosylated receptor tyrosine kinase of the hepatocyte growth factor (HGF), composed of an α and a β chain. Upon ligand binding, C‐Met…”
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Front Cover: Molecular Epitope Determination of Aptamer Complexes of the Multidomain Protein C‐Met by Proteolytic Affinity‐Mass Spectrometry (ChemMedChem 4/2020)
Published in ChemMedChem (17-02-2020)“…The Front Cover shows the interaction epitopes of the extracellular structure of human C‐Met receptor protein complexes with two DNA‐aptamers of 60 and 64…”
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Antibody Epitope of Human α‐Galactosidase A Revealed by Affinity Mass Spectrometry: A Basis for Reversing Immunoreactivity in Enzyme Replacement Therapy of Fabry Disease
Published in ChemMedChem (08-05-2018)“…α‐Galactosidase (αGal) is a lysosomal enzyme that hydrolyses the terminal α‐galactosyl moiety from glycosphingolipids. Mutations in the encoding genes for αGal…”
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Investigation of Tumor Differentiation Factor (TDF)‐induced Cell Differentiation using Mass Spectrometry
Published in The FASEB journal (01-04-2015)“…Abstract only Tumor differentiation factor is a protein, produced by the pituitary gland and is secreted into the bloodstream. TDF is known to induce…”
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Rational Design, Synthesis, and Characterization of Glycoconjugates as Potential Vaccines against Tuberculosis
Published in Proceedings (01-08-2019)“…Tuberculosis (TB) is the first cause of death from infectious diseases. [...]…”
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Application layer protocol for IoT using wireless sensor networks communication protocols
Published in 2017 9th International Congress on Ultra Modern Telecommunications and Control Systems and Workshops (ICUMT) (01-11-2017)“…This paper aims at providing a communication architecture in order to enable the integration of traditional Wireless Sensor Networks into the Internet of…”
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